Results 121 to 130 of about 9,480 (220)
Communications BiologyTwo mammalian homologs of systemic RNA interference defective protein 1 (SID-1) (SIDT1/2) are suggested to function as double-stranded RNA (dsRNA) transporters for extracellular dsRNA uptake or for release of incorporated dsRNA from lysosome to cytoplasm.
Yoshinori Hirano +5 more
doaj +1 more source
Acid ceramidase-1 (ASAH1/aCDase) an important for anticancer drug discovery: a review
Future Journal of Pharmaceutical SciencesBackground Dysregulated sphingolipid metabolism has emerged as a major pathway in multiple human cancers. Sphingolipids are major structural components of cell membranes, playing key roles in maintaining structural integrity, fluidity, and barrier ...
Seemarani M. Pawar +2 more
doaj +1 more source
Background and ObjectivesSpinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME) due to acid ceramidase deficiency is a rare disorder, allelic with Farber disease, resulting from recessive ASAH1 variants. Patients present in early childhood with muscle weakness due to anterior horn degeneration and/or progressive drug-resistant myoclonic ...
Cuinat, Silvestre +16 more
openaire +1 more source
European Journal of HistochemistryLaryngeal cancer is diagnosed approximately 20% of head and neck cancers worldwide1. Among the potential sphingolipid-based treatment methods for the treatment of these fatal cancers2 acid ceramidase inhibition is indicated as a beneficial treatment ...
doaj +1 more source
Rhinovirus infection promotes suppression of sphingosine and enhanced bacterial infection in cystic fibrosis airways. [PDF]
J Biol ChemWilson GC +5 more
europepmc +1 more source
ASAH2 deficiency affects sphingolipid homeostasis and neuromotor control, causing a progressive neurological disorder. [PDF]
HGG AdvScala M +10 more
europepmc +1 more source