Results 1 to 10 of about 908,827 (288)

Long non-coding RNAs-sphingolipid metabolism nexus: Potential targets for cancer treatment

Pharmacological Research
Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators of cancer pathogenesis, influencing various cellular processes and contributing to tumorigenesis.
Qiuju Wang, Man Lu
exaly   +4 more sources

Dysregulation of sphingolipid metabolism contributes to the pathogenesis of chronic myeloid leukemia [PDF]

Cell Death and Disease
Chronic myeloid leukemia (CML) is primarily driven by the BCR::ABL1 oncoprotein, which has potent tyrosine kinase activity. BCR::ABL1 has been shown to facilitate several metabolic processes, including glycolysis, lipid synthesis, and protein synthesis ...
Yinyin Xie, Qinghua Zeng, Zhiwei Chen, Jiachun Song, Fuhui Wang, Dan Liu, Xiaojian Sun, Yuanliang Zhang, Qiuhua Huang   +8 more
doaj   +3 more sources

Sphingolipid metabolism is associated with osteosarcoma metastasis and prognosis: Evidence from interaction analysis

Frontiers in Endocrinology, 2022
BackgroundMetabolism is widely involved in the occurrence and development of cancer. However, its role in osteosarcoma (OS) has not been elucidated.MethodsThe open-accessed data included in this study were downloaded from The Cancer Genome Atlas (TCGA ...
Xinyue Hu, Xin Zhou, Jue Zhang, Liangliang Li   +3 more
exaly   +3 more sources

Evolutionary diversity of sphingolipid metabolism proteins in fungi [PDF]

IMA Fungus
Fungi are adapted to survive across environments with fluctuating oxygen availability. Transition to terrestrial and parasitic lifestyles required remodeling of the cell membrane, including sphingolipid composition. Ceramides occupy a central position in
Magdalena Płecha, Blanka Sokołowska, Drishtee Barua, Julia Bartczak, Maria Sobczyk, Dagmara Koperska, Anna Kułakowska, Adam Komosa, Anna Muszewska   +8 more
doaj   +4 more sources

The Role of Sphingolipid Metabolism and Neuron Death in Ischemic Stroke: A New Perspective from Bioinformatics [PDF]

Brain and Behavior
Background Ischemic stroke (IS) is a leading cause of death and disability worldwide, but traditional risk factors do not fully explain its pathophysiology. Neuronal death in IS is influenced by multiple pathways, including sphingolipid metabolism, which
Zhong‐can Chen, Fang‐biao Xu, Sen Hu, Qiang Cui, Hugo Andrade Barazarte, Jing Zhang, Li‐na Suo, Jian‐jun Gu, Jiang‐yu Xue   +8 more
doaj   +2 more sources

Regulation of sphingolipid metabolism in the immune microenvironment of gastric cancer: current insights and future directions [PDF]

Frontiers in Oncology
In recent years, the role of sphingolipid metabolism in the tumor immune microenvironment has gradually gained attention, particularly in gastric cancer research.
Yunqi Hua, Gangling Zhang, Yubo Liu, Xiaoling Tian, Xinyi Zhang, Ge Song, Qinggang Tian, Fangrui Yin   +7 more
doaj   +2 more sources

Sphingolipid metabolism-related genes B4GALNT1 and CERS4 as prognostic biomarkers in lung adenocarcinoma. [PDF]

PLoS ONE
Sphingolipid metabolism is an important component of various biological processes, particularly in cancer pathology. This metabolic pathway significantly influences the behavior of cancer cells by regulating growth, apoptosis, and survival.
Jieun Jeon, Junho Kang, Jae-Hyung Park, Jae-Ho Lee, Dong Eun Kim, Woo-Jae Park, Shin Kim   +6 more
doaj   +2 more sources

A novel sphingolipid metabolism-related long noncoding RNA signature predicts the prognosis, immune landscape and therapeutic response in pancreatic adenocarcinoma

Heliyon
Sphingolipid metabolism affects prognosis and resistance to immunotherapy in patients with cancer and is an emerging target in cancer therapy with promising diagnostic and prognostic value.
Xu Zhengyang, Xiaolan He
exaly   +3 more sources

Sphingolipid metabolism-related genes as diagnostic markers in pneumonia-induced sepsis: the AUG model [PDF]

Scientific Reports
Pneumonia-induced sepsis (PIS) is a life-threatening condition with high mortality rates, necessitating the identification of biomarkers and therapeutic targets.
Jing Wu, Xiaomin Li, Zhihao Chen, Yiting Lin, Qiuyue Long, Mingzheng Jiang, Xiaoyi Hu, Shixu Song, Hongli Ye, Jiwei Li, Fangfang Wu, Jianshi Zheng, Minghui Wang, Zhancheng Gao, Pu Ning, Yali Zheng   +15 more
doaj   +2 more sources

Development of Comorbid Depression after Social Fear Conditioning in Mice and Its Effects on Brain Sphingolipid Metabolism

Cells, 2023
Currently, there are no animal models for studying both specific social fear and social fear with comorbidities. Here, we investigated whether social fear conditioning (SFC), an animal model with face, predictive and construct validity for social anxiety
Iulia Zoicas, Christiane Mühle, Fabian Schumacher, Burkhard Kleuser, Johannes Kornhuber   +4 more
doaj   +1 more source