Results 1 to 10 of about 35,165 (291)
Long non-coding RNAs-sphingolipid metabolism nexus: Potential targets for cancer treatment
Pharmacological ResearchLong non-coding RNAs (lncRNAs) have emerged as pivotal regulators of cancer pathogenesis, influencing various cellular processes and contributing to tumorigenesis.
Yan Chen +8 more
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Editorial: Sphingolipid metabolism and cancer
Frontiers in Oncology, 2022 Cancer; Metabolism ...
Margarita M. Ivanova +2 more
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Dysregulation of sphingolipid metabolism contributes to the pathogenesis of chronic myeloid leukemia [PDF]
Cell Death and DiseaseChronic myeloid leukemia (CML) is primarily driven by the BCR::ABL1 oncoprotein, which has potent tyrosine kinase activity. BCR::ABL1 has been shown to facilitate several metabolic processes, including glycolysis, lipid synthesis, and protein synthesis ...
Yinyin Xie +8 more
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Dysregulation of sphingolipid metabolism in pain [PDF]
Frontiers in PharmacologyPain is a clinical condition that is currently of great concern and is often caused by tissue or nerve damage or occurs as a concomitant symptom of a variety of diseases such as cancer. Severe pain seriously affects the functional status of the body. However, existing pain management programs are not fully satisfactory.
Yanju Bao, Bao Yanju
exaly +5 more sources
Nuclear Sphingolipid Metabolism [PDF]
Annual Review of Physiology, 2012 Nuclear lipid metabolism is implicated in various processes, including transcription, splicing, and DNA repair. Sphingolipids play roles in numerous cellular functions, and an emerging body of literature has identified roles for these lipid mediators in distinct nuclear processes.
Natasha C, Lucki, Marion B, Sewer
openaire +3 more sources
The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy
Nature Communications, 2023 Sphingolipids are ubiquitous components of membranes and function as bioactive lipid signaling molecules. Here, through genetic screening and lipidomics analyses, we find that the endoplasmic reticulum (ER) calcium channel Csg2 integrates sphingolipid ...
Shiyan Liu +10 more
doaj +2 more sources
Role of sphingolipid metabolism in neurodegeneration [PDF]
Journal of Neurochemistry, 2020 AbstractSphingolipids are a class of lipids highly enriched in the central nervous system (CNS), which shows great diversity and complexity, and has been implicated in CNS development and function. Alterations in sphingolipid metabolism have been described in multiple diseases, including those affecting the central nervous system (CNS). In this review,
Manal Alaamery +7 more
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The Role of Sphingolipid Metabolism and Neuron Death in Ischemic Stroke: A New Perspective from Bioinformatics [PDF]
Brain and BehaviorBackground Ischemic stroke (IS) is a leading cause of death and disability worldwide, but traditional risk factors do not fully explain its pathophysiology. Neuronal death in IS is influenced by multiple pathways, including sphingolipid metabolism, which
Zhong‐can Chen +8 more
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Frontiers in Endocrinology, 2022 BackgroundMetabolism is widely involved in the occurrence and development of cancer. However, its role in osteosarcoma (OS) has not been elucidated.MethodsThe open-accessed data included in this study were downloaded from The Cancer Genome Atlas (TCGA ...
Xinyue Hu +3 more
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Evolutionary diversity of sphingolipid metabolism proteins in fungi [PDF]
IMA FungusFungi are adapted to survive across environments with fluctuating oxygen availability. Transition to terrestrial and parasitic lifestyles required remodeling of the cell membrane, including sphingolipid composition. Ceramides occupy a central position in
Magdalena Płecha +8 more
doaj +4 more sources