Results 1 to 10 of about 50,463 (250)

The Role of Sphingolipid Metabolism and Neuron Death in Ischemic Stroke: A New Perspective from Bioinformatics [PDF]

Brain and Behavior
Background Ischemic stroke (IS) is a leading cause of death and disability worldwide, but traditional risk factors do not fully explain its pathophysiology. Neuronal death in IS is influenced by multiple pathways, including sphingolipid metabolism, which
Zhong‐can Chen, Fang‐biao Xu, Sen Hu, Qiang Cui, Hugo Andrade Barazarte, Jing Zhang, Li‐na Suo, Jian‐jun Gu, Jiang‐yu Xue   +8 more
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Regulation of sphingolipid metabolism in the immune microenvironment of gastric cancer: current insights and future directions [PDF]

Frontiers in Oncology
In recent years, the role of sphingolipid metabolism in the tumor immune microenvironment has gradually gained attention, particularly in gastric cancer research.
Yunqi Hua, Gangling Zhang, Yubo Liu, Xiaoling Tian, Xinyi Zhang, Ge Song, Qinggang Tian, Fangrui Yin   +7 more
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Dysregulation of sphingolipid metabolism contributes to the pathogenesis of chronic myeloid leukemia [PDF]

Cell Death and Disease
Chronic myeloid leukemia (CML) is primarily driven by the BCR::ABL1 oncoprotein, which has potent tyrosine kinase activity. BCR::ABL1 has been shown to facilitate several metabolic processes, including glycolysis, lipid synthesis, and protein synthesis ...
Yinyin Xie, Qinghua Zeng, Zhiwei Chen, Jiachun Song, Fuhui Wang, Dan Liu, Xiaojian Sun, Yuanliang Zhang, Qiuhua Huang   +8 more
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Sphingolipid metabolism-related genes B4GALNT1 and CERS4 as prognostic biomarkers in lung adenocarcinoma. [PDF]

PLoS ONE
Sphingolipid metabolism is an important component of various biological processes, particularly in cancer pathology. This metabolic pathway significantly influences the behavior of cancer cells by regulating growth, apoptosis, and survival.
Jieun Jeon, Junho Kang, Jae-Hyung Park, Jae-Ho Lee, Dong Eun Kim, Woo-Jae Park, Shin Kim   +6 more
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Sphingolipid metabolism-related genes as diagnostic markers in pneumonia-induced sepsis: the AUG model [PDF]

Scientific Reports
Pneumonia-induced sepsis (PIS) is a life-threatening condition with high mortality rates, necessitating the identification of biomarkers and therapeutic targets.
Jing Wu, Xiaomin Li, Zhihao Chen, Yiting Lin, Qiuyue Long, Mingzheng Jiang, Xiaoyi Hu, Shixu Song, Hongli Ye, Jiwei Li, Fangfang Wu, Jianshi Zheng, Minghui Wang, Zhancheng Gao, Pu Ning, Yali Zheng   +15 more
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Sphingolipid metabolism is associated with osteosarcoma metastasis and prognosis: Evidence from interaction analysis

Frontiers in Endocrinology, 2022
BackgroundMetabolism is widely involved in the occurrence and development of cancer. However, its role in osteosarcoma (OS) has not been elucidated.MethodsThe open-accessed data included in this study were downloaded from The Cancer Genome Atlas (TCGA ...
Xinyue Hu, Xin Zhou, Jue Zhang, Liangliang Li   +3 more
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Development of Comorbid Depression after Social Fear Conditioning in Mice and Its Effects on Brain Sphingolipid Metabolism

Cells, 2023
Currently, there are no animal models for studying both specific social fear and social fear with comorbidities. Here, we investigated whether social fear conditioning (SFC), an animal model with face, predictive and construct validity for social anxiety
Iulia Zoicas, Christiane Mühle, Fabian Schumacher, Burkhard Kleuser, Johannes Kornhuber   +4 more
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Using BODIPY FL-Sphingolipid Analogs to Study Sphingolipid Metabolism in Mouse Embryonic Stem Cells

Bio-Protocol, 2022
Sphingolipids are important structural components of cellular membranes. They also function as prominent signaling molecules to control a variety of cellular events, such as cell growth, differentiation, and apoptosis.
Wei Fan, Xiaoling Li
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Effects of sphingolipid metabolism disorders on endothelial cells

Lipids in Health and Disease, 2022
Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction.
Yali Lai, Yue Tian, Xintong You, Jiangnan Du, Jianmei Huang   +4 more
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Ceramide synthase CERS4 gene downregulation is associated with KRAS mutation in colorectal cancer

Scientific Reports, 2023
Ceramide, the central molecule in sphingolipid synthesis, is a bioactive lipid that serves as a regulatory molecule in the anti-inflammatory responses, apoptosis, programmed necrosis, autophagy, and cell motility of cancer cells.
Tamuro Hayama, Kotaro Hama, Tsuyoshi Ozawa, Yuko Fujiwara, Keijiro Nozawa, Keiji Matsuda, Kazuaki Yokoyama, Yojiro Hashiguchi, Hiroki Ochiai, Takeyuki Misawa, Takeo Fukagawa   +10 more
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