Results 31 to 40 of about 908,827 (288)
Inhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity
Cell & Bioscience, 2022 Osteosarcoma is the most common primary bone tumor, with a poor prognosis owing to the lack of efficient molecular-based targeted therapies. Previous studies have suggested an association between CD151 and distinct consequences in osteosarcoma ...
Hongsheng Wang +12 more
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Computational modeling of sphingolipid metabolism [PDF]
BMC Systems Biology, 2015 As suggested by the origin of the word, sphingolipids are mysterious molecules with various roles in antagonistic cellular processes such as autophagy, apoptosis, proliferation and differentiation. Moreover, sphingolipids have recently been recognized as important messengers in cellular signaling pathways.
Weronika Wronowska +3 more
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Sphingolipids and their metabolism in physiology and disease [PDF]
Nature Reviews Molecular Cell Biology, 2017 Studies of bioactive lipids in general and sphingolipids in particular have intensified over the past several years, revealing an unprecedented and unanticipated complexity of the lipidome and its many functions, which rivals, if not exceeds, that of the genome or proteome.
Yusuf A, Hannun, Lina M, Obeid
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Scientific Reports, 2022 Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are essential nutrients that can affect inflammatory responses. While n-3 PUFAs are generally considered beneficial for cardiovascular disease and obesity, the effects on asthma, the most common ...
Andrea Heras +13 more
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Ceramide Metabolism Enzymes—Therapeutic Targets against Cancer
Medicina, 2021 Sphingolipids are both structural molecules that are essential for cell architecture and second messengers that are involved in numerous cell functions. Ceramide is the central hub of sphingolipid metabolism. In addition to being the precursor of complex
Ana Gomez-Larrauri +4 more
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Analysis of metabolites of fungal balls in the paranasal sinuses
BMC Infectious Diseases, 2022 Fungal ball sinusitis is characterized by complex fungus infections with non-invasive inflammation. But no research reported fungal ball composition and metabolic-related product types currently.
Xiaoqing Zhang +5 more
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The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei [PDF]
, 2010 Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K. +2 more
core +1 more source
Sphingolipid metabolism during TLR4-mediated macrophage activation [PDF]
, 2021 Macrophage activation in response to stimulation of Toll-like receptor 4 (TLR4) provides a paradigm for investigating energy metabolism that regulate the inflammatory response.
Behmoaras, Jacques
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Sphingolipid Metabolism and Neutral Sphingomyelinases [PDF]
, 2013 Sphingolipids are an important class of lipid molecules that play fundamental roles in our cells and body. Beyond a structural role, it is now clearly established that sphingolipids serve as bioactive signaling molecules to regulate diverse processes including inflammatory signaling, cell death, proliferation, and pain sensing. Sphingolipid metabolites
Michael V, Airola, Yusuf A, Hannun
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Frontiers in Physiology, 2021 Aberrant sphingolipid metabolism contributes to cardiac pathophysiology. Emerging evidence found that an increased level of ceramide during the inflammatory phase of post-myocardial infarction (MI) served as a biomarker and was associated with cardiac ...
Tong Hua +4 more
doaj +1 more source