Results 11 to 20 of about 908,827 (288)

Nuclear Sphingolipid Metabolism [PDF]

Annual Review of Physiology, 2012
Nuclear lipid metabolism is implicated in various processes, including transcription, splicing, and DNA repair. Sphingolipids play roles in numerous cellular functions, and an emerging body of literature has identified roles for these lipid mediators in
Natasha C. Lucki, Marion B. Sewer
core   +3 more sources

The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy

Nature Communications, 2023
Sphingolipids are ubiquitous components of membranes and function as bioactive lipid signaling molecules. Here, through genetic screening and lipidomics analyses, we find that the endoplasmic reticulum (ER) calcium channel Csg2 integrates sphingolipid ...
Shiyan Liu, Mutian Chen, Yichang Wang, Yuqing Lei, Ting Huang, Yabin Zhang, Sin Man Lam, Huihui Li, Shiqian Qi, Jia Geng, Kefeng Lu   +10 more
doaj   +2 more sources

Role of sphingolipid metabolism in neurodegeneration [PDF]

Journal of Neurochemistry, 2021
Sphingolipids are a class of lipids highly enriched in the central nervous system (CNS), which shows great diversity and complexity, and has been implicated in CNS development and function.
Salam Massadeh, Chun‐Cheih Chao, Moneera Alsuwailm, Francisco J. Quintana, Quintana, Francisco J., Michael A. Wheeler, Massadeh, Salam, Alaamery, Manal, Wheeler, Michael A., Nora Aljawini, Chao, Chun-Cheih, Alsuwailm, Moneera, Nour Albesher, Albesher, Nour, Manal Alaamery, Aljawini, Nora   +15 more
core   +3 more sources

Translational aspects of sphingolipid metabolism

Trends in Molecular Medicine, 2007
Sphingolipids, a major class of lipids in cell membranes, play diverse roles in biological processes. As bioactive and structural molecules, they have signaling activities and biophysical properties that are essential for regulating various cellular ...
Hannun, Yusuf A, Zeidan, Youssef H
core   +3 more sources

Sphingolipid metabolism and obesity-induced inflammation [PDF]

Frontiers in Endocrinology, 2013
Obesity is a metabolic disorder developed by overnutrition and a major cause for insulin resistance and cardiovascular events. Since adipose tissue is one of the major sites for the synthesis and secretion of cytokines, enlarged adipose tissue in obese ...
Se-Chan eKang, Bo-Rahm eKim, Su-Yeon eLee, Tae-Sik ePark   +3 more
doaj   +3 more sources

Editorial: Sphingolipid metabolism and cancer

Frontiers in Oncology, 2022
Cancer; Metabolism ...
Margarita M. Ivanova, Irina U. Agoulnik, Matilde E. LLeonart   +2 more
doaj   +4 more sources

Abnormal islet sphingolipid metabolism in type 1 diabetes [PDF]

, 2018
AIMS/HYPOTHESIS: Sphingolipids play important roles in beta cell physiology, by regulating proinsulin folding and insulin secretion and in controlling apoptosis, as studied in animal models and cell cultures.
K Dahl-Jørgensen (20885705), LA Claessens (21881309), BPC Koeleman (10456634), KF Hanssen (21833252), NG Morgan (21853058), CE Mathews (21853043), IC Gerling (21853040), MA Russell (13951002), BO Roep (21881312), F Pociot (13308969), L Krogvold (21833219), K Buschard (21881315), S Kaur (9895766), LJ Holm (21881303), JP Hasselby (21881306)   +14 more
core   +6 more sources

Using BODIPY FL-Sphingolipid Analogs to Study Sphingolipid Metabolism in Mouse Embryonic Stem Cells

Bio-Protocol, 2022
Sphingolipids are important structural components of cellular membranes. They also function as prominent signaling molecules to control a variety of cellular events, such as cell growth, differentiation, and apoptosis.
Wei Fan, Xiaoling Li
doaj   +1 more source

Effects of sphingolipid metabolism disorders on endothelial cells

Lipids in Health and Disease, 2022
Many cardiovascular disorders, including atherosclerosis, hypertension, coronary heart disease, diabetes, etc., are characterized by endothelial cell dysfunction.
Yali Lai, Yue Tian, Xintong You, Jiangnan Du, Jianmei Huang   +4 more
doaj   +1 more source

Ceramide synthase CERS4 gene downregulation is associated with KRAS mutation in colorectal cancer

Scientific Reports, 2023
Ceramide, the central molecule in sphingolipid synthesis, is a bioactive lipid that serves as a regulatory molecule in the anti-inflammatory responses, apoptosis, programmed necrosis, autophagy, and cell motility of cancer cells.
Tamuro Hayama, Kotaro Hama, Tsuyoshi Ozawa, Yuko Fujiwara, Keijiro Nozawa, Keiji Matsuda, Kazuaki Yokoyama, Yojiro Hashiguchi, Hiroki Ochiai, Takeyuki Misawa, Takeo Fukagawa   +10 more
doaj   +1 more source