Long non-coding RNAs-sphingolipid metabolism nexus: Potential targets for cancer treatment
Pharmacological ResearchLong non-coding RNAs (lncRNAs) have emerged as pivotal regulators of cancer pathogenesis, influencing various cellular processes and contributing to tumorigenesis.
Yan Chen +8 more
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Probiotic Bacillus subtilis protects against α-synuclein aggregation in C. elegans [PDF]
, 2020 How the gut microbiome affects Parkinson's disease remains unclear. Goya et al. show that the probiotic B. subtilis strain PXN21 inhibits and clears α-synuclein aggregation in a C. elegans model.
Arnaouteli, Sofia +9 more
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Frontiers in Oncology, 2022 Biologically active sphingolipids are closely related to the growth, differentiation, aging, and apoptosis of cancer cells. Some sphingolipids, such as ceramides, are favorable metabolites in the sphingolipid metabolic pathway, usually mediating ...
Run-Ze Li +19 more
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The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy
Nature Communications, 2023 Sphingolipids are ubiquitous components of membranes and function as bioactive lipid signaling molecules. Here, through genetic screening and lipidomics analyses, we find that the endoplasmic reticulum (ER) calcium channel Csg2 integrates sphingolipid ...
Shiyan Liu +10 more
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Sphingolipids as emerging mediators in retina degeneration [PDF]
, 2019 The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
Prado Spalm, Facundo Heber +3 more
core +1 more source
A Comprehensive Review on the Interplay between Neisseria spp. and Host Sphingolipid Metabolites
Cells, 2021 Sphingolipids represent a class of structural related lipids involved in membrane biology and various cellular processes including cell growth, apoptosis, inflammation and migration.
Simon Peters +3 more
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The low intestinal and hepatic toxicity of hydrolyzed fumonisin B1 correlates with its inability to alter the metabolism of sphingolipids [PDF]
, 2012 Fumonisins are mycotoxins frequently found as natural contaminants in maize, where they are produced by the plant pathogen Fusarium verticillioides. They are toxic to animals and exert their effects through mechanisms involving disruption of sphingolipid
Bracarense, Ana-Paula +8 more
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Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry[S]
Journal of Lipid Research, 2018 Sphingolipids constitute a dynamic metabolic network that interconnects several bioactive molecules, including ceramide (Cer), sphingosine (Sph), Sph 1-phosphate, and Cer 1-phosphate.
Justin M. Snider +4 more
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Inhibition of sphingolipid metabolism in osteosarcoma protects against CD151-mediated tumorigenicity
Cell & Bioscience, 2022 Osteosarcoma is the most common primary bone tumor, with a poor prognosis owing to the lack of efficient molecular-based targeted therapies. Previous studies have suggested an association between CD151 and distinct consequences in osteosarcoma ...
Hongsheng Wang +12 more
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Scientific Reports, 2022 Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are essential nutrients that can affect inflammatory responses. While n-3 PUFAs are generally considered beneficial for cardiovascular disease and obesity, the effects on asthma, the most common ...
Andrea Heras +13 more
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