Results 41 to 50 of about 908,827 (288)

Sphingolipid Signaling in Metabolic Disorders [PDF]

Cell Metabolism, 2012
Sphingolipids, ubiquitous membrane lipids in eukaryotes, carry out a myriad of critical cellular functions. The past two decades have seen significant advances in sphingolipid research, and in 2010 a first sphingolipid receptor modulator was employed as a human therapeutic. Furthermore, cellular signaling mechanisms regulated by sphingolipids are being
Hla, Timothy, Dannenberg, Andrew J.
openaire   +2 more sources

Dysregulated Sphingolipid Metabolism in Endometriosis [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2014
In endometriosis, the establishment and subsistence of ectopic lesions outside the endometrium suggest an altered cellular state for pathological hyperplasia. Sphingolipids are bioactive compounds, and their biosynthesis and metabolism modulate a range of cellular processes including proliferation, migration and apoptosis.
Yie Hou, Lee, Chin Wen, Tan, Abhishek, Venkatratnam, Chuen Seng, Tan, Liang, Cui, Seong Feei, Loh, Linda, Griffith, Steven R, Tannenbaum, Jerry Kok Yen, Chan   +8 more
openaire   +2 more sources

The Emerging Mycotoxin 2-Amino-14, 16-Dimethyloctadecan-3-ol (AOD) Alters Transcriptional Regulation and Sphingolipid Metabolism and Undergoes N-Acylation by HepG2 Cells

Toxins
2-Amino-14,16-dimethyloctadecan-3-ol (AOD) is commonly found in foods contaminated with Fusarium avenaceum, particularly cereals or fruits, and is structurally related to Fusarium mycotoxins (fumonisins) and mammalian sphingoid bases, especially 1 ...
Shenlong Mo, Zhenying Hu, Huaiyi Zhu, Boming Yu, Xiaoyan Chen, Yu Chen, Alfred H. Merrill, Jingjing Duan   +7 more
doaj   +1 more source

Fumonisin B1: A Tool for Exploring the Multiple Functions of Sphingolipids in Plants

Frontiers in Plant Science, 2020
Fumonisin toxins are produced by Fusarium fungal pathogens. Fumonisins are structural analogs of sphingosine and potent inhibitors of ceramide synthases (CerSs); they disrupt sphingolipid metabolism and cause disease in plants and animals.
Hong-Yun Zeng, Chun-Yu Li, Nan Yao
doaj   +1 more source

A circular network of coregulated sphingolipids dictates lung cancer growth and progression

EBioMedicine, 2021
Background: Sphingolipid metabolism is among the top dysregulated pathways in non-small cell lung carcinomas (NSCLC). However, the molecular control of sphingolipid metabolic reprogramming in cancer progression remains unclear.
Qiong Meng, Xueting Hu, Xinbao Zhao, Xiangzhan Kong, Ya-Ming Meng, Yitian Chen, Liangping Su, Xue Jiang, Xiaoyi Qiu, Cheng Huang, Chao Liu, Minghui Wang, Ping-Pui Wong   +12 more
doaj   +1 more source

The sphingolipid anteome: implications for evolution of the sphingolipid metabolic pathway

FEBS Letters, 2022
Modern cell membranes contain a bewildering complexity of lipids, among them sphingolipids (SLs). Advances in mass spectrometry have led to the realization that the number and combinatorial complexity of lipids, including SLs, is much greater than previously appreciated.
Tania C. B. Santos, Tamir Dingjan, Anthony H. Futerman   +2 more
openaire   +2 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Autophagy in the light of sphingolipid metabolism [PDF]

Apoptosis, 2015
Maintenance of cellular homeostasis requires tight and coordinated control of numerous metabolic pathways, which are governed by interconnected networks of signaling pathways and energy-sensing regulators. Autophagy, a lysosomal degradation pathway by which the cell self-digests its own components, has over the past decade been recognized as an ...
Harvald, Eva Bang, Olsen, Anne Sofie Braun, Færgeman, Nils J.; id_orcid 0000-0002-9281-5287   +2 more
openaire   +2 more sources

Diminished Sphingolipid Metabolism, a Hallmark of Future Type 2 Diabetes Pathogenesis, Is Linked to Pancreatic β Cell Dysfunction

iScience, 2020
Summary: Gestational diabetes mellitus (GDM) is the top risk factor for future type 2 diabetes (T2D) development. Ethnicity profoundly influences who will transition from GDM to T2D, with high risk observed in Hispanic women.
Saifur R. Khan, Yousef Manialawy, Andreea Obersterescu, Brian J. Cox, Erica P. Gunderson, Michael B. Wheeler   +5 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source