Results 41 to 50 of about 35,165 (291)

How Does CBG Administration Affect Sphingolipid Deposition in the Liver of Insulin-Resistant Rats?

, 2023
Background: Cannabigerol (CBG), a non-psychotropic phytocannabinoid found in Cannabis sativa plants, has been the focus of recent studies due to its potential therapeutic properties.
Piotr Franciszek Kurzyna, Ewa Harasim-Symbor, Karolina Konstantynowicz-Nowicka, Adrian Chabowski, Adam Hołownia, Wiktor Bzdęga   +5 more
core   +1 more source

The Emerging Mycotoxin 2-Amino-14, 16-Dimethyloctadecan-3-ol (AOD) Alters Transcriptional Regulation and Sphingolipid Metabolism and Undergoes N-Acylation by HepG2 Cells

Toxins
2-Amino-14,16-dimethyloctadecan-3-ol (AOD) is commonly found in foods contaminated with Fusarium avenaceum, particularly cereals or fruits, and is structurally related to Fusarium mycotoxins (fumonisins) and mammalian sphingoid bases, especially 1 ...
Shenlong Mo, Zhenying Hu, Huaiyi Zhu, Boming Yu, Xiaoyan Chen, Yu Chen, Alfred H. Merrill, Jingjing Duan   +7 more
doaj   +1 more source

Fumonisin B1: A Tool for Exploring the Multiple Functions of Sphingolipids in Plants

Frontiers in Plant Science, 2020
Fumonisin toxins are produced by Fusarium fungal pathogens. Fumonisins are structural analogs of sphingosine and potent inhibitors of ceramide synthases (CerSs); they disrupt sphingolipid metabolism and cause disease in plants and animals.
Hong-Yun Zeng, Chun-Yu Li, Nan Yao
doaj   +1 more source

Myristic Acid Remodels Sphingolipid Metabolism via Dual Pathways: Canonical d18-Sphingolipid Regulation and Non-Canonical d16-Sphingolipid Synthesis. [PDF]

Nutrients
Background: Myristic acid (MA), a 14-carbon saturated fatty acid, serves as a precursor for the synthesis of non-canonical d16-sphingoid bases via its activated form, C14:0-CoA. However, its broader regulatory role in sphingolipid (SL) metabolism remains
You Y, Zeng Q, Hu Z, Chen Y, Zhan M, Wang Y, Duan J.   +6 more
europepmc   +2 more sources

Sphingolipid and ceramide homeostasis : potential therapeutic targets

, 2012
Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction.
Smith, Terry, Simon A. Young, Denny, Paul, Young, Simon, Denny, Paul W., Mina, J.G., Mina, John, Denny, P.W., Smith, Terry K., Mina, John G., John G. Mina, Young, S.A., Smith, T.K., Paul W. Denny, Young, Simon A., Terry K. Smith   +15 more
core   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

The sphingolipid anteome: implications for evolution of the sphingolipid metabolic pathway

FEBS Letters, 2022
Modern cell membranes contain a bewildering complexity of lipids, among them sphingolipids (SLs). Advances in mass spectrometry have led to the realization that the number and combinatorial complexity of lipids, including SLs, is much greater than previously appreciated.
Tania C. B. Santos, Tamir Dingjan, Anthony H. Futerman   +2 more
openaire   +2 more sources

Dysregulated Sphingolipid Metabolism in Endometriosis [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2014
In endometriosis, the establishment and subsistence of ectopic lesions outside the endometrium suggest an altered cellular state for pathological hyperplasia. Sphingolipids are bioactive compounds, and their biosynthesis and metabolism modulate a range of cellular processes including proliferation, migration and apoptosis.
Yie Hou, Lee, Chin Wen, Tan, Abhishek, Venkatratnam, Chuen Seng, Tan, Liang, Cui, Seong Feei, Loh, Linda, Griffith, Steven R, Tannenbaum, Jerry Kok Yen, Chan   +8 more
openaire   +2 more sources

Diminished Sphingolipid Metabolism, a Hallmark of Future Type 2 Diabetes Pathogenesis, Is Linked to Pancreatic β Cell Dysfunction

iScience, 2020
Summary: Gestational diabetes mellitus (GDM) is the top risk factor for future type 2 diabetes (T2D) development. Ethnicity profoundly influences who will transition from GDM to T2D, with high risk observed in Hispanic women.
Saifur R. Khan, Yousef Manialawy, Andreea Obersterescu, Brian J. Cox, Erica P. Gunderson, Michael B. Wheeler   +5 more
doaj   +1 more source

The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei

, 2010
Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K., Young, Simon A., Young, Simon Alan   +2 more
core   +1 more source