Results 51 to 60 of about 35,165 (291)

Altered hepatic sphingolipid metabolism in insulin resistant mice: Role of advanced glycation endproducts [PDF]

, 2021
High plasma levels of the sphingolipid intermediates ceramide (Cer) and sphingosine-1-phosphate (S1P) are suggested to be involved in the development of insulin resistance (IR).
Gaens, Katrien, Wouters, Kristiaan, Dal Bello, Federica, Mastrocola, Raffaella, Collotta, Debora, Medana, Claudio, Dal Bello, F., Collotta, D., Mastrocola, R., Medana, C., Cento, A. S., Schalkwijk, Casper G.; id_orcid, Cento, Alessia S., Aragno, M., Wouters, Kristiaan; id_orcid, Collino, M., Aragno, Manuela, Schalkwijk, Casper G., Collino, Massimo   +18 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Sphingolipids in High Fat Diet and Obesity-Related Diseases

Mediators of Inflammation, 2015
Nutrient oversupply associated with a high fat diet (HFD) significantly alters cellular metabolism, and specifically including sphingolipid metabolism.
Songhwa Choi, Ashley J. Snider
doaj   +1 more source

sphingolipid metabolism-png

, 2014
unigenes mapped to sphingolipid ...
Karen Fugate (480954)
core   +1 more source

Aberrant TGFβ signalling contributes to dysregulation of sphingolipid metabolism in intrauterine growth restriction [PDF]

, 2015
Context: Sphingolipids function as key bioactive mediators that regulate cell fate events in a variety of systems. Disruptions in sphingolipid metabolism characterize several human pathologies.
Yinon Y., Todros T., Ermini L., Sallais J., Post M., Todros, Tullia, Xu J., Tagliaferro A., Caniggia I., Chauvin S.   +9 more
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Tubercidin enhances apoptosis in serum-starved and hypoxic mouse cardiomyocytes by inducing nuclear speckle condensation

BMC Cardiovascular Disorders
Tubercidin, known for its antimicrobial, antiparasitic, and anticancer effects, faces clinical limitations due to adverse effects, especially cardiotoxicity risks for those with ischemic cardiomyopathy.
Guowen Shen, Qingni Cheng, Lunmin Liang, Yaping Qin, Yunzhu Cao, Quanzhong Li, Shengjun Xiao   +6 more
doaj   +1 more source

sphingolipid metabolism-html

, 2014
unigenes mapped to sphingolipid ...
Karen Fugate (480954)
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Functional roles of sphingolipids in immunity and their implication in disease

Experimental and Molecular Medicine, 2023
Sphingolipids, which are components of cellular membranes and organ tissues, can be synthesized or degraded to modulate cellular responses according to environmental cues, and the balance among the different sphingolipids is important for directing ...
Mingyu Lee, Suh Yeon Lee, Yoe-Sik Bae
doaj   +1 more source