Results 71 to 80 of about 908,827 (288)

Genetic Disorders of Simple Sphingolipid Metabolism

, 2013
International audienceA better understanding of the functions sphingolipids play in living organisms can be achieved by analyzing the biochemical and physiological changes that result from genetic alterations of sphingolipid metabolism.
Virginie Albinet, Albinet, Virginie, Virginie Garcia, Thorsten Hornemann, Marie-Lise Bats, Thierry Levade, Nathalie Andrieu-Abadie, Garcia, Virginie, Bedia, Carmen, Carmen Bedia, Bruno Ségui, Andrieu-Abadie, Nathalie, Hornemann, Thorsten, Levade, Thierry, Bats, Marie-Lise, Frédérique Sabourdy, Sabourdy, Frédérique, Ségui, Bruno   +17 more
core   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

A systematic simulation of the effect of salicylic acid on sphingolipid metabolism

Frontiers in Plant Science, 2015
The phytohormone salicylic acid (SA) affects plant development and defense responses. Recent studies revealed that SA also participates in the regulation of sphingolipid metabolism, but the details of this regulation remain to be explored.
Chao eShi, Jian eYin, Zhe eLiu, Jian-xin eWu, Qi eZhao, Jian eRen, Nan eYao   +6 more
doaj   +1 more source

Sphingolipid metabolism in neural cells

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2006
Sphingolipids were discovered more than a century ago in the brain. Cerebrosides and sphingomyelins were named so because they were first isolated from neural tissue. Although glycosphingolipids and especially those containing sialic acid in their oligosaccharide moiety are particularly abundant in the brain, sphingolipids are ubiquitous cellular ...
van Echten-Deckert, Gerhild, Herget, Thomas   +1 more
openaire   +2 more sources

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Sphingolipid metabolic enzyme GLA expression in gliomas: prognostic implications and therapeutic potential

Frontiers in Oncology
BackgroundGliomas are the most common primary brain tumors and show marked molecular heterogeneity and variable clinical outcomes, highlighting the need for reliable prognostic biomarkers.MethodsWe analyzed TCGA and CGGA datasets to identify prognosis ...
Dan Wei, Qiuyang Su, Xiangkun Li, Hongbin Li, Dongyi Jin, Zhixiong Pan, Moujie Yang, Guihong Liu, Yuming Du, Wei Dong, Wei Dong   +10 more
doaj   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

ASAH1-mediated sphingolipid metabolic reprogramming in venetoclax resistance of AML: beyond the monocytic phenotypes

BMC Cancer
Background Venetoclax (VEN) in combination with hypomethylating agents has emerged as a pivotal therapy for elderly acute myeloid leukemia (AML) patients ineligible for intensive chemotherapy.
Lei Zhao, Xinrong Xiang, Ailing Zhong, Hongbin Yu, Jinjun Yang, Mengran Chen, Hong Ding, Chenlu Yang, Yu Wu   +8 more
doaj   +1 more source

Estimating sphingolipid metabolism and trafficking in cultured cells using radiolabeled compounds

, 1999
The use of radioactive metabolites, particularly radiolabeled complex sphingolipids, represents an experimental approach to investigating different aspects of sphingolipid metabolism.
Riboni L., Viani P., Tettamanti G.
core   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source