Results 81 to 90 of about 908,827 (288)

Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis.

PLoS Pathogens, 2012
Lipids are key components in the viral life cycle that affect host-pathogen interactions. In this study, we investigated the effect of HCV infection on sphingolipid metabolism, especially on endogenous SM levels, and the relationship between HCV ...
Yuichi Hirata, Kazutaka Ikeda, Masayuki Sudoh, Yuko Tokunaga, Akemi Suzuki, Leiyun Weng, Masatoshi Ohta, Yoshimi Tobita, Ken Okano, Kazuhisa Ozeki, Kenichi Kawasaki, Takuo Tsukuda, Asao Katsume, Yuko Aoki, Takuya Umehara, Satoshi Sekiguchi, Tetsuya Toyoda, Kunitada Shimotohno, Tomoyoshi Soga, Masahiro Nishijima, Ryo Taguchi, Michinori Kohara   +21 more
doaj   +1 more source

Aberrant TGFβ signalling contributes to dysregulation of sphingolipid metabolism in intrauterine growth restriction [PDF]

, 2015
Context: Sphingolipids function as key bioactive mediators that regulate cell fate events in a variety of systems. Disruptions in sphingolipid metabolism characterize several human pathologies.
Yinon Y., Todros T., Ermini L., Sallais J., Post M., Todros, Tullia, Xu J., Tagliaferro A., Caniggia I., Chauvin S.   +9 more
core   +1 more source

SIRT5‐Mediated Desuccinylation of ACAA2 Protects Against Calcium Oxalate‐Induced Kidney Injury by Regulating Fatty Acid Oxidation to Suppress Mitochondrial Oxidative Injury and Ferroptosis

Advanced Science, EarlyView.
The SIRT5/ACAA2 axis maintains lipid metabolic homeostasis in RTECs by promoting ACAA2 desuccinylation and preserving its stability and enzymatic activity, thereby sustaining FAO and limiting PUFA and PUFA‐containing phospholipid accumulation. Under CaOx stress, SIRT5 downregulation impairs FAO, promotes oxidative stress and ferroptosis, and enhances ...
Qinhong Jiang, Caitao Dong, Yuchen Liu, Yuanquan Lou, Wenlong Lin, Sheng Li, Ziqi He   +6 more
wiley   +1 more source

Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver

Background and aims Steatotic liver disease (SLD), which encompasses various causes of fat accumulation in the liver, is a major cause of liver fibrosis.
Leslie, Jack, Alrawashdeh, Wasfi, Sabey, Eleanor, Gruevska, Aleksandra, Johnson, Sophia, Robinson, Stuart M, Evangelista, Laila, Hoare, Matthew, Thursz, Mark, Maude, Hannah, Collins, Amy L, Moir, John, Safinia, Niloufar, White, Steven, Forlano, Roberta, Goldin, Robert, Cebola, Inˆes, Thakkar, Rohan, Carling, David, Hall, Zoe, French, Jeremy, Mann, Derek A, Oakley, Fiona, Perpin˜án, Elena, Manousou, Pinelopi, Posma, Joram M   +25 more
core   +1 more source

Sphingolipid and methionine metabolism in aging

Journal of Cell Science
ABSTRACT Sphingolipids are essential for cell membrane structure and the regulation of organelle functions. Sphingolipid synthesis requires the coordinated activity of multiple organelles, including the endoplasmic reticulum, Golgi, lysosomes and mitochondria, which are connected via membrane contact sites.
Daniel Adebayo, Eseiwi Obaseki, Kashvi Vasudeva, Marwa Aboumourad, Ahmad Sleiman, Sumit Bandyopadhyay, Lindsey Kreinbring, Hanaa Hariri   +7 more
openaire   +2 more sources

Thematic Review Series: Sphingolipids. Nuclear sphingolipids: metabolism and signaling [PDF]

Journal of Lipid Research, 2008
Sphingolipids are most prominently expressed in the plasma membrane, but recent studies have pointed to important signaling and regulatory roles in the nucleus. The most abundant nuclear sphingolipid is sphingomyelin (SM), which occurs in the nuclear envelope (NE) as well as intranuclear sites.
Robert W. Ledeen, Gusheng Wu
openaire   +2 more sources

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

Functional profiling and visualization of the sphingolipid metabolic network in vivo

EMBO Reports
Sphingolipids govern diverse cellular processes; their dysregulation underlies numerous diseases. Despite extensive characterizations, understanding the orchestration of the sphingolipid network within living organisms remains challenging. We established
Fei-Yang Tzou, Cheng-Li Hong, Kai-Hung Chen, John P Vaughen, Wan-Syuan Lin, Chia-Heng Hsu, Irma Magaly Rivas-Serna, Kai-Yi Hsu, Shuk-Man Ho, Michael Raphael Panganiban, Hsin-Ti Hsieh, Yi-Jhan Li, Yi Hsiao, Hsin-Chun Yeh, Cheng-Yu Yu, Hong-Wen Tang, Ya-Hui Chou, Chia-Lin Wu, Chung-Chuan Lo, Vera C Mazurak, M Thomas Clandinin, Shu-Yi Huang, Chih-Chiang Chan   +22 more
doaj   +1 more source

Normal and Dysregulated Sphingolipid Metabolism: Contributions to Podocyte Injury and Beyond

Cells
Podocyte health is vital for maintaining proper glomerular filtration in the kidney. Interdigitating foot processes from podocytes form slit diaphragms which regulate the filtration of molecules through size and charge selectivity. The abundance of lipid
Matthew Tolerico, Sandra Merscher, Alessia Fornoni   +2 more
doaj   +1 more source

Importance of Sphingolipids and Inhibitors of Sphingolipid Metabolism as Components of Animal Diets [PDF]

The Journal of Nutrition, 1997
Sphingolipids are highly bioactive compounds that participate in the regulation of cell growth, differentiation, diverse cell functions, and apoptosis. They are present in both plant and animal foods in appreciable amounts, but little is known about their nutritional significance.
A H, Merrill, E M, Schmelz, E, Wang, D L, Dillehay, L G, Rice, F, Meredith, R T, Riley   +6 more
openaire   +2 more sources