Results 81 to 90 of about 35,165 (291)

Bandgap‐Engineered PtxTey:Ag2Te Composite Quantum Dots Enable Programmable NIR‐II Imaging and Photothermal‐Immune Synergistic Therapy

Advanced Science, EarlyView.
A bandgap‐engineered PtxTey:Ag2Te quantum dot platform enables tunable NIR‐IIb emission for deep‐tissue imaging and mild photothermal therapy. Conjugation with αPD‐L1 confers dual tumor targeting and real‐time monitoring of PD‐L1 dynamics. Mild photothermal modulation induces immune reprogramming, enhancing checkpoint blockade efficacy and achieving ...
Jing Liu, Rui Xu, Quan Wu, Tian‐Xin Xiao, Lai‐Xi Zhao, Lei Sun, Ya‐Wen Zheng, Liang Dong, Zhi‐Quan Tian, Haibo Wang   +9 more
wiley   +1 more source

Thematic Review Series: Sphingolipids. Nuclear sphingolipids: metabolism and signaling [PDF]

Journal of Lipid Research, 2008
Sphingolipids are most prominently expressed in the plasma membrane, but recent studies have pointed to important signaling and regulatory roles in the nucleus. The most abundant nuclear sphingolipid is sphingomyelin (SM), which occurs in the nuclear envelope (NE) as well as intranuclear sites.
Robert W. Ledeen, Gusheng Wu
openaire   +2 more sources

Legionella pneumophila restrains autophagy by modulating the host's sphingolipid metabolism

, 2016
Punctum to: Rolando M, et al. Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy. Proc Natl Acad Sci USA (2016) 113(7):1901- 6; http://dx.doi.org/10.1073/pnas.1522067113.International audienceSphingolipids are ...
Escoll, Pedro, Rolando, Monica, Buchrieser, Carmen   +2 more
core   +1 more source

Imaging‐Guided Live Single‐Cell Lipid Profiling of Leader and Follower Cellsduring Collective Migration of Triple‐Negative Breast Cancer Cells

Advanced Science, EarlyView.
Integrated single‐cell mass spectrometry reveals distinct lipidomic signatures that differentiate leader and follower phenotypes in migratory breast cancer cells. Phenotype‐specific alterations across various lipid classes, including fatty acids and phosphatidylcholines, underpin functional heterogeneity.
Xiaoyue Huang, Judit González Riera, Mai Nguyen, Jeremy Broekhuis, Sylvia E. Le Dévédec, Ahmed Ali, Thomas Hankemeier   +6 more
wiley   +1 more source

Sphingolipid metabolic enzyme GLA expression in gliomas: prognostic implications and therapeutic potential

Frontiers in Oncology
BackgroundGliomas are the most common primary brain tumors and show marked molecular heterogeneity and variable clinical outcomes, highlighting the need for reliable prognostic biomarkers.MethodsWe analyzed TCGA and CGGA datasets to identify prognosis ...
Dan Wei, Qiuyang Su, Xiangkun Li, Hongbin Li, Dongyi Jin, Zhixiong Pan, Moujie Yang, Guihong Liu, Yuming Du, Wei Dong, Wei Dong   +10 more
doaj   +1 more source

Regulation of sphingolipid and glycosphingolipid metabolism in extrahepatic tissues by endotoxin

Journal of Lipid Research, 2001
The host response to infection and inflammation is associated with multiple alterations in lipid metabolism. We have shown that endotoxin [lipopolysaccharide (LPS)] stimulates hepatic sphingolipid synthesis and increases ceramide and glucosylceramide ...
Riaz A. Memon, Walter M. Holleran, Yoshikazu Uchida, Arthur H. Moser, Carl Grunfeld, Kenneth R. Feingold   +5 more
doaj   +1 more source

Sphingolipid metabolism in neural cells

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2006
Sphingolipids were discovered more than a century ago in the brain. Cerebrosides and sphingomyelins were named so because they were first isolated from neural tissue. Although glycosphingolipids and especially those containing sialic acid in their oligosaccharide moiety are particularly abundant in the brain, sphingolipids are ubiquitous cellular ...
van Echten-Deckert, Gerhild, Herget, Thomas   +1 more
openaire   +2 more sources

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Functional profiling and visualization of the sphingolipid metabolic network in vivo

EMBO Reports
Sphingolipids govern diverse cellular processes; their dysregulation underlies numerous diseases. Despite extensive characterizations, understanding the orchestration of the sphingolipid network within living organisms remains challenging. We established
Fei-Yang Tzou, Cheng-Li Hong, Kai-Hung Chen, John P Vaughen, Wan-Syuan Lin, Chia-Heng Hsu, Irma Magaly Rivas-Serna, Kai-Yi Hsu, Shuk-Man Ho, Michael Raphael Panganiban, Hsin-Ti Hsieh, Yi-Jhan Li, Yi Hsiao, Hsin-Chun Yeh, Cheng-Yu Yu, Hong-Wen Tang, Ya-Hui Chou, Chia-Lin Wu, Chung-Chuan Lo, Vera C Mazurak, M Thomas Clandinin, Shu-Yi Huang, Chih-Chiang Chan   +22 more
doaj   +1 more source

Normal and Dysregulated Sphingolipid Metabolism: Contributions to Podocyte Injury and Beyond

Cells
Podocyte health is vital for maintaining proper glomerular filtration in the kidney. Interdigitating foot processes from podocytes form slit diaphragms which regulate the filtration of molecules through size and charge selectivity. The abundance of lipid
Matthew Tolerico, Sandra Merscher, Alessia Fornoni   +2 more
doaj   +1 more source