Results 91 to 100 of about 35,165 (291)

Importance of Sphingolipids and Inhibitors of Sphingolipid Metabolism as Components of Animal Diets [PDF]

The Journal of Nutrition, 1997
Sphingolipids are highly bioactive compounds that participate in the regulation of cell growth, differentiation, diverse cell functions, and apoptosis. They are present in both plant and animal foods in appreciable amounts, but little is known about their nutritional significance.
A H, Merrill, E M, Schmelz, E, Wang, D L, Dillehay, L G, Rice, F, Meredith, R T, Riley   +6 more
openaire   +2 more sources

Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver

Background and aims Steatotic liver disease (SLD), which encompasses various causes of fat accumulation in the liver, is a major cause of liver fibrosis.
Leslie, Jack, Alrawashdeh, Wasfi, Sabey, Eleanor, Gruevska, Aleksandra, Johnson, Sophia, Robinson, Stuart M, Evangelista, Laila, Hoare, Matthew, Thursz, Mark, Maude, Hannah, Collins, Amy L, Moir, John, Safinia, Niloufar, White, Steven, Forlano, Roberta, Goldin, Robert, Cebola, Inˆes, Thakkar, Rohan, Carling, David, Hall, Zoe, French, Jeremy, Mann, Derek A, Oakley, Fiona, Perpin˜án, Elena, Manousou, Pinelopi, Posma, Joram M   +25 more
core   +1 more source

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source

Mysterious sphingolipids: metabolic interrelationships at the center of pathophysiology

Frontiers in Physiology
Metabolic pathways are complex and intertwined. Deficiencies in one or more enzymes in a given pathway are directly linked with genetic diseases, most of them having devastating manifestations.
Rama Jamjoum, Saurav Majumder, Batoul Issleny, Johnny Stiban   +3 more
doaj   +1 more source

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

Sphingolipid and methionine metabolism in aging

Journal of Cell Science
ABSTRACT Sphingolipids are essential for cell membrane structure and the regulation of organelle functions. Sphingolipid synthesis requires the coordinated activity of multiple organelles, including the endoplasmic reticulum, Golgi, lysosomes and mitochondria, which are connected via membrane contact sites.
Daniel Adebayo, Eseiwi Obaseki, Kashvi Vasudeva, Marwa Aboumourad, Ahmad Sleiman, Sumit Bandyopadhyay, Lindsey Kreinbring, Hanaa Hariri   +7 more
openaire   +2 more sources

New Insights into the Role of Sphingolipid Metabolism in Melanoma

, 2020
Cutaneous melanoma is a deadly skin cancer whose aggressiveness is directly linked to its metastatic potency. Despite remarkable breakthroughs in term of treatments with the emergence of targeted therapy and immunotherapy, the prognosis for metastatic ...
Lorry Carrié, Carine Dufau, Virazels, Mathieu, Thierry Levade, Nathalie Andrieu-Abadie, Montfort, Anne, Anne Montfort, Bruno Ségui, Andrieu-Abadie, Nathalie, Levade, Thierry, Mathieu Virazels, Dufau, Carine, Carrié, Lorry, Ségui, Bruno   +13 more
core   +1 more source

Tissue‐Specific and Spatially Dependent Metabolic Signatures Perturbed by Injury in Male and Female Mice

Arthritis &Rheumatology, EarlyView.
Objective Osteoarthritis, the leading cause of disability worldwide, disproportionately affects women, yet sex remains an overlooked determinant. This disparity stems from sex‐specific differences in injury susceptibility—a major risk factor for disease.
Hope D. Welhaven, Avery H. Welfley, Priyanka P. Brahmachary, Mark Greenwood, Donald F. Smith, Brian Bothner, Ronald K. June   +6 more
wiley   +1 more source

Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis

, 2012
SummaryMitochondria are functionally and physically associated with heterotypic membranes, yet little is known about how these interactions impact mitochondrial outer-membrane permeabilization (MOMP) and apoptosis.
Kuwana, Tomomi, Green, Douglas R., Chipuk, Jerry E., Clarke, Christopher J., Bharti, Archana, Obeid, Lina M., Siskind, Leah J., McStay, Gavin P.   +7 more
core   +2 more sources

De novo Synthesis of Sphingolipids Is Defective in Experimental Models of Huntington's Disease

Frontiers in Neuroscience, 2017
Alterations of lipid metabolism have been frequently associated with Huntington's disease (HD) over the past years. HD is the most common neurodegenerative disorder, with a complex pathogenic profile, typically characterized by progressive striatal and ...
Alba Di Pardo, Abdul Basit, Andrea Armirotti, Enrico Amico, Salvatore Castaldo, Giuseppe Pepe, Federico Marracino, Fabio Buttari, Anna F. Digilio, Vittorio Maglione   +9 more
doaj   +1 more source