Results 111 to 120 of about 908,827 (288)

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Comparative Analysis of Biological Sphingolipids with Glycerophospholipids and Diacylglycerol by LC-MS/MS

Metabolites, 2014
Liquid chromatography-electrospray ionization mass spectrometry (LC-MS) is an effective and popular technique used in lipid metabolomic studies. Although many LC-MS methods enabling the determination of sphingolipid molecular species have been reported,
Hideo Ogiso, Makoto Taniguchi, Shinichi Araya, Shinya Aoki, Lusi Oka Wardhani, Yuka Yamashita, Yoshibumi Ueda, Toshiro Okazaki   +7 more
doaj   +1 more source

Selective N‐Functionalization of Pyrazoles

European Journal of Organic Chemistry, EarlyView.
This review traces the evolution of regioselective N‐functionalization strategies for pyrazoles, a key class of nitrogen heterocycles widely used in medicinal chemistry. Due to rapid tautomerism, N‐functionalization often lacks selectivity, leading to poor and unpredictable regioisomeric outcomes.
Lucas Popek, Matthias Schrader, Christopher J. Teskey   +2 more
wiley   +1 more source

Dysregulation of sphingolipid metabolism in pain

Frontiers in Pharmacology
Pain is a clinical condition that is currently of great concern and is often caused by tissue or nerve damage or occurs as a concomitant symptom of a variety of diseases such as cancer. Severe pain seriously affects the functional status of the body. However, existing pain management programs are not fully satisfactory.
Jianfeng Wang, Guangda Zheng, Linfeng Wang, Linghan Meng, Juanxia Ren, Lu Shang, Dongtao Li, Yanju Bao   +7 more
openaire   +3 more sources

Nutrition and Metabolic Diseases: A Systematic Review of Functional Foods, Medicinal Plants, Phytochemicals, Bioactive Compounds and Nutrients Effective Against Metabolic Diseases

Food Chemistry International, EarlyView.
The study demonstrates how functional foods, medicinal plants, phytochemicals, bioactive compounds and essential nutrients combat metabolic diseases. It highlights their mechanisms, including antioxidant, anti‐inflammatory, insulin‐sensitising, lipid‐regulating, gut microbiota‐modulating and mitochondrial‐enhancing effects, leading to improved ...
Chinaza Godswill Awuchi, Sana Noreen, Sonia Morya   +2 more
wiley   +1 more source

Extracellular vesicles derived from edible plants and edible fungi: Compositional characteristics, engineering strategies and biofunctions

Food Biomacromolecules, EarlyView.
Non‐animal extracellular vesicles as bioactive‐compound carriers: compositional characteristics, engineering strategies, and biofunctions. Abstract Animal‐derived extracellular vesicles (EVs) were widely used for bioactive compound delivery but constrained by complex origins, potential immunogenicity, and pathogen contamination.
Jiahao Yu, Rongheng Chen, Yuxuan Liu, Yizhen Xie, Fangyu Fan, Simin Feng, Ping Shao   +6 more
wiley   +1 more source

Food Safety Management and Mycotoxins Nexus: A Systematic Review of Mycotoxins Toxicity, Detoxification, Nutritional Impacts, and Economic Importance

Food Safety and Health, EarlyView.
The graphical abstract illustrates the interconnected relationship between food safety management, mycotoxin toxicity, and detoxification strategies, highlighting how preventive measures across the food chain can minimize mycotoxin contamination and reduce adverse health effects in humans/animals.
Chinaza Godswill Awuchi
wiley   +1 more source

Sphingolipid metabolism meets natural bioactives: A new perspective on metabolic disease intervention

Pharmacological Research
Dysregulation of sphingolipid metabolism, particularly ceramide accumulation, has emerged as a central pathogenic driver of metabolic diseases including obesity, type 2 diabetes, metabolic dysfunction associated steatotic liver disease, and ...
Yingrui He, Jian Tan, Jinxin Liu, Rongzhen Zhong, Linshu Jiang, Yuchao Zhao   +5 more
doaj   +1 more source

Seed lipid profiles of perennial ryegrass: Global patterns and differentiation of ryegrass cultivars and Epichloë endophytes

Grassland Research, EarlyView.
Seed lipid profiles from three ryegrass cultivars infected with AR501 show distinct changes in the medium‐chain diacylglycerols, triacylglycerols and sphingolipids. The differential peal LN745.5052_5.78 can be identified as PG 16:0_18:2 with the supporting ms2 fragmentation spectrum. Abstract Background Forage perennial ryegrass (Lolium perenne L.) has
Mingshu Cao, Wei Zhang, Wade J. Mace, Christine R. Voisey, David E. Hume, Richard D. Johnson, Sushma Prakash   +6 more
wiley   +1 more source

Crosstalk Between Parkinson's Disease and Colorectal Cancer: Genetic Mechanisms, Gut Microbiota, and Therapeutic Insights

Health Care Science, EarlyView.
This review elucidates the crosstalk between Parkinson's disease and colorectal cancer, driven by shared genetics (PRKN, PINK1, DJ‐1) involving oxidative stress, cell cycle regulation, and inflammation. It identifies the gut microbiota—via functional amyloids and short‐chain fatty acids (SCFAs)—as a mechanistic bridge, offering insights for dual ...
Jiacheng Ying, Zhengyuan Fang, Cheng Zhang, Xu Liu, Jianzhi Cui, Zezhi Li, Jiayin Tang   +6 more
wiley   +1 more source