Results 121 to 130 of about 35,165 (291)

Sphingolipid metabolism enzymes as targets for anticancer therapy

, 2004
Treatment with anti-cancer agents in most cases ultimately results in apoptotic cell death of the target tumour cells. Unfortunately, tumour cells can develop multidrug resistance, e.g., by a reduced propensity to engage in apoptosis by which they become
Sietsma, H, Kok, JW
core   +1 more source

Abnormal islet sphingolipid metabolism in type 1 diabetes

, 2018
AIMS/HYPOTHESIS: Sphingolipids play important roles in beta cell physiology, by regulating proinsulin folding and insulin secretion and in controlling apoptosis, as studied in animal models and cell cultures.
K Dahl-Jørgensen (20885705), LA Claessens (21881309), BPC Koeleman (10456634), KF Hanssen (21833252), NG Morgan (21853058), CE Mathews (21853043), IC Gerling (21853040), MA Russell (13951002), BO Roep (21881312), F Pociot (13308969), L Krogvold (21833219), K Buschard (21881315), S Kaur (9895766), LJ Holm (21881303), JP Hasselby (21881306)   +14 more
core  

Sphingolipid Metabolism: A New Therapeutic Opportunity for Brain Degenerative Disorders [PDF]

, 2018
Neurodegenerative diseases represent a class of fatal brain disorders for which the number of effective therapeutic options remains limited with only symptomatic treatment accessible. Multiple studies show that defects in sphingolipid pathways are shared
Alba Di Pardo, Vittorio Maglione, MAGLIONE, VITTORIO, Di Pardo, Alba   +3 more
core   +1 more source

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Sphingolipid metabolism in non-alcoholic fatty liver diseases

, 2019
International audienceNon-alcoholic fatty liver disease (NAFLD) involves a panel of pathologies starting with hepatic steatosis and continuing to irreversible and serious conditions like steatohepatitis (NASH) and hepatocarcinoma. NAFLD is multifactorial
Guillou, Hervé, Loiseau, Nicolas, Régnier, Marion, Polizzi, Arnaud   +3 more
core   +1 more source

Metabolomic and lipidomic signatures of Helicobacter pylori infection: Unveiling biochemical pathways associated with neurodegeneration

iMetaOmics, EarlyView.
Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal, Tarun Prakash Verma, Siddharth Singh, Hamendra Parmar, Hem Chandra Jha   +4 more
wiley   +1 more source

Optical control of sphingolipid biosynthesis using photoswitchable sphingosines

Journal of Lipid Research
Sphingolipid metabolism comprises a complex interconnected web of enzymes, metabolites, and modes of regulation that influence a wide range of cellular and physiological processes.
Matthijs Kol, Alexander J.E. Novak, Johannes Morstein, Christian Schröer, Tolulope Sokoya, Svenja Mensing, Sergei M. Korneev, Dirk Trauner, Joost C.M. Holthuis   +8 more
doaj   +1 more source

Re-Configuration of Sphingolipid Metabolism by Oncogenic Transformation

, 2014
The sphingolipids are one of the major lipid families in eukaryotes, incorporating a diverse array of structural variants that exert a powerful influence over cell fate and physiology. Increased expression of sphingosine kinase 1 (SPHK1), which catalyses
Timothy A. Couttas, Anthony Don, Xin Lim, Anthony S. Don, Timothy Couttas, Xin Y. Lim, Don, AS, Lim, XY, Couttas, TA   +8 more
core   +1 more source

Functionally complementary bacterial inoculant coordinates arbuscular mycorrhizal fungi to improve Angelica sinensis root yield and quality

iMetaOmics, EarlyView.
Comprehensive understanding of how diverse PGPR strains enhance the rhizosphere microenvironment remains a considerable challenge. Here, we provide experimental evidence that a functionally synergistic composite microbial formulation can markedly enhance growth performance and improve the quality attributes in Angelica sinensis.
Zongyu Zhang, Yun Wang, Jiecai Zhao, Gaofeng Chen, Andéole Niyongabo Turatsinze, Liang Yue, Yuan Tian, Xiaofan Xie, Ailing Ye, Meilan Zhang, Lingling Wu, Zengxiang Guo, Yubao Zhang, Ruoyu Wang   +13 more
wiley   +1 more source

Sphingosine kinase and sphingosine-1-phosphate regulate epithelial cell architecture by the modulation of de novo sphingolipid synthesis.

PLoS ONE, 2019
Sphingolipids regulate several aspects of cell behavior and it has been demonstrated that cells adjust their sphingolipid metabolism in response to metabolic needs.
Bruno Jaime Santacreu, Lucila Gisele Pescio, Daniela Judith Romero, Gerardo Raúl Corradi, Norma Sterin-Speziale, Nicolás Octavio Favale   +5 more
doaj   +1 more source