Results 121 to 130 of about 908,827 (288)

New Insights into the Role of Sphingolipid Metabolism in Melanoma

, 2020
Cutaneous melanoma is a deadly skin cancer whose aggressiveness is directly linked to its metastatic potency. Despite remarkable breakthroughs in term of treatments with the emergence of targeted therapy and immunotherapy, the prognosis for metastatic ...
Lorry Carrié, Carine Dufau, Virazels, Mathieu, Thierry Levade, Nathalie Andrieu-Abadie, Montfort, Anne, Anne Montfort, Bruno Ségui, Andrieu-Abadie, Nathalie, Levade, Thierry, Mathieu Virazels, Dufau, Carine, Carrié, Lorry, Ségui, Bruno   +13 more
core   +1 more source

Gut microbiome seasonality is associated with dietary plasticity and coexistence in three sympatric Pamir ungulates

iMetaOmics, EarlyView.
This graphical abstract outlines a multi‐omics framework investigating the seasonal dietary composition and gut microbial communities of three coexisting ungulate species inhabiting the extreme high‐altitude Pamir Plateau (Ovis ammon polii, Capra sibirica, and Pseudois nayaur). By integrating dietary DNA metabarcoding, 16S rRNA gene sequencing, shotgun
Dilala Tuoliu, Lijiao Zhang, Muyang Wang, Wenxuan Xu, Kathreen Ruckstuhl, António Alves da Silva, Joana Alves, Hongchen Jiang, Weikang Yang   +8 more
wiley   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Deregulated sphingolipid metabolism and membrane organization in neurodegenerative disorders

, 2010
Sphingolipids are polar membrane lipids present as minor components in eukaryotic cell membranes. Sphingolipids are highly enriched in nervous cells, where they exert important biological functions.
M. Piccinini, Nicoletta Loberto, A.E.G. Prinetti, Barbara Buccinnà, Federica Scandroglio, Marco Piccinini, F. Scandroglio, Giovanni DeMarco, Vanna Chigorno, Elisa Lupino, S. Sonnino, E. Lupino, M. Aureli, Sandro Sonnino, Alessandro Prinetti, S. Prioni, Annarosa Lomartire, M. Rinaudo, Maria Teresa Rinaudo, N. Loberto, A. Lomartire, Massimo Aureli, Simona Prioni, V.L. Chigorno, B. Buccinà, G. De Marco   +25 more
core   +1 more source

Enhanced peripheral blood mononuclear cell lipid metabolism drives poor immunotherapy response via ferroptotic stress‐induced T cell exhaustion in hepatocellular carcinoma

Interdisciplinary Medicine, EarlyView.
Integrated multi‐omics reveals that CD36‐mediated lipid overload in PBMCs drives T cell exhaustion via sub‐lethal ferroptotic stress and AKT suppression. This systemic metabolic signature serves as a robust predictor of immunotherapy response in HCC, suggesting that modulating lipid metabolism can rescue immune fitness.
Ying Zhu, Zhouyu Ning, Yong Deng, Changjing Huang, Hui Li, Yun Sun, Zhiqiang Meng   +6 more
wiley   +1 more source

Optical control of sphingolipid biosynthesis using photoswitchable sphingosines

Journal of Lipid Research
Sphingolipid metabolism comprises a complex interconnected web of enzymes, metabolites, and modes of regulation that influence a wide range of cellular and physiological processes.
Matthijs Kol, Alexander J.E. Novak, Johannes Morstein, Christian Schröer, Tolulope Sokoya, Svenja Mensing, Sergei M. Korneev, Dirk Trauner, Joost C.M. Holthuis   +8 more
doaj   +1 more source

Drought Risk in Mango and Avocado Orchards: Insights Into Plant Water Relations and Irrigation‐Related Agronomic Solutions

Irrigation and Drainage, EarlyView.
ABSTRACT Climate change is making water availability more uncertain, with growing consequences for the productivity and long‐term sustainability of tropical and subtropical fruit orchards. Mangifera indica L. and Persea americana Mill. both require large amounts of water to sustain growth and productivity.
Eleonora Cataldo
wiley   +1 more source

Assessing Metabolic and Reproductive Consequences of Prenatal Paracetamol Exposure in Female CD1 Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Paracetamol is a widely used analgesic during pregnancy; however, emerging evidence suggests it may act as an endocrine/metabolism disrupting compound. Using an F1 female CD1 mouse model, this study scrutinized the long‐term metabolic and reproductive consequences linked to intrauterine paracetamol exposure.
Bita Entezari, Deniz Bozdag, Elif İnce‐Erguc, Aylin Buhur, Cansin Sirin Tomruk, Suna Sabuncuoglu, Altug Yavasoglu, Hande Gurer‐Orhan   +7 more
wiley   +1 more source

Enzymes of sphingolipid metabolism in Drosophila melanogaster

, 2011
Sphingolipids are important structural components of membranes that delimit the boundaries of cellular compartments, cells and organisms. They play an equally important role as second messengers, and transduce signals across or within the compartments ...
Acharya, Jairaj K., Acharya, Usha
core   +1 more source

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu, Xiao‐Bo Wan, Yong‐Shun Liang, Tian Lan, Hao Liang   +4 more
wiley   +1 more source