Results 101 to 110 of about 908,827 (288)

Sphingolipid Metabolism and Signalling Pathways in Heart Failure: From Molecular Mechanism to Therapeutic Potential [PDF]

Meng Zhao,1– 3 Rutao Bian,2 Xuegong Xu,2 Junpeng Zhang,2 Li Zhang,2 Yi Zheng2 1The First Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou, Henan Province, People’s Republic of China; 2Department of Cardiology, Zhengzhou ...
Zhao M, Zheng Y, Bian R, Zhang J, Zhang L, Xu X   +5 more
core  

From apex to base: Uncovering spatial metabolic adaptation in Antarctic mosses

Bulletin of the Korean Chemical Society, EarlyView.
Antarctic mosses survive extreme cold, desiccation, UV exposure, and oxidative stress. We analyzed three species by separating apical, middle, and basal zones. Each zone showed distinct metabolite patterns and biological roles, revealing spatial metabolic specialization. The results suggest that whole‐plant survival depends on coordinated contributions
Fatima Tuz Zahra, Yelim Lee, Hyoungseok Lee, Amancio de Souza, Manhoi Hur, Katayoon Dehesh, Jungeun Lee, Sunghwan Kim   +7 more
wiley   +1 more source

Legionella pneumophila restrains autophagy by modulating the host's sphingolipid metabolism

, 2016
Punctum to: Rolando M, et al. Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy. Proc Natl Acad Sci USA (2016) 113(7):1901- 6; http://dx.doi.org/10.1073/pnas.1522067113.International audienceSphingolipids are ...
Escoll, Pedro, Rolando, Monica, Buchrieser, Carmen   +2 more
core   +1 more source

Transcriptomic Profiling of SLC and ABC Transporters in the Human Term Placenta

Clinical Pharmacology &Therapeutics, EarlyView.
Solute carriers (SLC) and ATP‐binding cassette (ABC) transporters are essential for placental solute exchange and fetal protection, yet their transcriptomic profiles in the human placenta remain poorly characterized. Although fetal sex influences placental development and function, its impact on transporter expression is unclear.
Elijah Marsh Jung, Nicholas Ieronimakis, Bothaina Mousa, Emily D. Sheikh, Sarah E. Ligon, Joshua W. Monson, Jennifer R. Damicis, Hillary J. Kinsman, Lydia E. Bettridge, Samuel L.M. Arnold, Edward J. Kelly, Jashvant D. Unadkat, Joanne Wang   +12 more
wiley   +1 more source

Sphingolipid Regulation of Genome Stability: Stress Signaling, Chromatin Control, and Organelle Dysfunction

DNA
Sphingolipid metabolism has emerged as a regulatory interface between lipid homeostasis, organelle stress, and genome maintenance. Although sphingolipids are essential structural components of cellular membranes, specific metabolites also function as ...
Lauren Kupec, Karyme Garcia Lopez, Shashank Nadimpalli, Santiago Lima, Jason Newton   +4 more
doaj   +1 more source

De novo Synthesis of Sphingolipids Is Defective in Experimental Models of Huntington's Disease

Frontiers in Neuroscience, 2017
Alterations of lipid metabolism have been frequently associated with Huntington's disease (HD) over the past years. HD is the most common neurodegenerative disorder, with a complex pathogenic profile, typically characterized by progressive striatal and ...
Alba Di Pardo, Abdul Basit, Andrea Armirotti, Enrico Amico, Salvatore Castaldo, Giuseppe Pepe, Federico Marracino, Fabio Buttari, Anna F. Digilio, Vittorio Maglione   +9 more
doaj   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry

Frontiers in Cell and Developmental Biology, 2019
Sphingolipids are a class of lipids that share a sphingoid base backbone. They exert various effects in eukaryotes, ranging from structural roles in plasma membranes to cellular signaling.
Dominik Wigger, Erich Gulbins, Erich Gulbins, Burkhard Kleuser, Fabian Schumacher, Fabian Schumacher   +5 more
doaj   +1 more source

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

Transcriptomics, lipidomics, and single-nucleus RNA sequencing integration: exploring sphingolipids in MASH-HCC progression

Cell & Bioscience
Background & aims Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses various conditions, ranging from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosis.
Jing Zeng, Grayson Way, Nan Wu, Xixian Jiang, Yun-ling Tai, Derrick Zhao, Lianyong Su, Qianhua Yan, Xuan Wang, Emily C. Gurley, Phillip B. Hylemon, Sayed Obaidullah Aseem, Arun J. Sanyal, Jiangao Fan, Huiping Zhou   +14 more
doaj   +1 more source