Results 101 to 110 of about 35,165 (291)

Runx1 orchestrates sphingolipid metabolism and glucocorticoid resistance in lymphomagenesis [PDF]

, 2017
The three-membered RUNX gene family includes RUNX1, a major mutational target in human leukemias, and displays hallmarks of both tumour suppressors and oncogenes.
A. Terry, McDonald, A., Cameron, E.R., M. Bell, Borland, G., Kilbey, A., Zhang, Q., A. Kilbey, E.R. Cameron, S. Wotton, Neil, J.C., Bell, M., J.C. Neil, Wotton, S., A. McDonald, Q. Zhang, N. Mackay, G. Borland, Wakelam, M.J.O., M.J.O. Wakelam, Terry, A., Mackay, N.   +21 more
core   +1 more source

Washed Microbiota Transplantation Improves Patients with Overweight by the Gut Microbiota and Sphingolipid Metabolism

, 2023
Background: Overweight (OW) and obesity have become increasingly serious public health problems worldwide. The clinical impact of washed microbiota transplantation (WMT) from healthy donors in OW patients is unclear.
Lei Wu, Xin-Jian Lu, Wen-Ying Lin, De-Jiang Lin, Zi-Han Lin, Xuan Hu, Tao Liu, Jia-Ting Xu, Qing-Ping Wu, Hao-Jie Zhong, Xing-Xiang He   +10 more
core   +1 more source

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry

Frontiers in Cell and Developmental Biology, 2019
Sphingolipids are a class of lipids that share a sphingoid base backbone. They exert various effects in eukaryotes, ranging from structural roles in plasma membranes to cellular signaling.
Dominik Wigger, Erich Gulbins, Erich Gulbins, Burkhard Kleuser, Fabian Schumacher, Fabian Schumacher   +5 more
doaj   +1 more source

Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial–mesenchymal transition and pulmonary niche formation of breast cancer

Biological Reviews, EarlyView.
ABSTRACT The complexity of breast cancer (BC) lung metastasis lies in the capacity of tumour cells to interact efficiently with distant organs to promote colonisation, a process that involves the sophisticated coordination of inherent cellular plasticity and the remodelling of the distant microenvironment.
Jian Lu, Reza Shirazi Nia, Junjie Sun, Chrysa Filippopoulou, Daniel De Vega, Pengtao Hu, Heng Liang, Hang Yao, Chaoyue Pan, Xiaoyan Wu, Xidong Gu, Xiaohong Xie, Georgios Giamas   +12 more
wiley   +1 more source

Deregulated sphingolipid metabolism and membrane organization in neurodegenerative disorders

, 2010
Sphingolipids are polar membrane lipids present as minor components in eukaryotic cell membranes. Sphingolipids are highly enriched in nervous cells, where they exert important biological functions.
M. Piccinini, Nicoletta Loberto, A.E.G. Prinetti, Barbara Buccinnà, Federica Scandroglio, Marco Piccinini, F. Scandroglio, Giovanni DeMarco, Vanna Chigorno, Elisa Lupino, S. Sonnino, E. Lupino, M. Aureli, Sandro Sonnino, Alessandro Prinetti, S. Prioni, Annarosa Lomartire, M. Rinaudo, Maria Teresa Rinaudo, N. Loberto, A. Lomartire, Massimo Aureli, Simona Prioni, V.L. Chigorno, B. Buccinà, G. De Marco   +25 more
core   +1 more source

Plasma Exosome Metabolomics Reveal Stage‐Specific Alterations in Elderly Women With Premetabolic and Metabolic Syndrome

Chronic Diseases and Translational Medicine, EarlyView.
Shared differential metabolites identified across the three sample groups. (A) Venn diagram of differential metabolites between the two comparison groups; Based on the detected levels of these overlapping differential metabolites, (B) d‐Arabitol, (C) Triclosan, (D) Iloprost, (E) Tetracosanoic acid, and (F) Omeprazole sulfone. Box plots were constructed
Mengtao Qian, Dan Nie, Qianyi Gao, Xingbo Mo, Huan Zhang   +4 more
wiley   +1 more source

Comparative Analysis of Biological Sphingolipids with Glycerophospholipids and Diacylglycerol by LC-MS/MS

Metabolites, 2014
Liquid chromatography-electrospray ionization mass spectrometry (LC-MS) is an effective and popular technique used in lipid metabolomic studies. Although many LC-MS methods enabling the determination of sphingolipid molecular species have been reported,
Hideo Ogiso, Makoto Taniguchi, Shinichi Araya, Shinya Aoki, Lusi Oka Wardhani, Yuka Yamashita, Yoshibumi Ueda, Toshiro Okazaki   +7 more
doaj   +1 more source

Sphingolipid-Transporting Proteins as Cancer Therapeutic Targets [PDF]

, 2019
This article was supported by the German Research Foundation (DFG) and the Open Access Publication Fund of Humboldt-Universität zu Berlin.The understanding of the role of sphingolipid metabolism in cancer has tremendously increased in the past ten years.
Arenz, Christoph, Kevin Prause, Max Wilde, Christoph Arenz, Samaha, Doaa, Hamdo, Housam H., Housam H. Hamdo, Doaa Samaha, Prause, Kevin, Wilde, Max   +9 more
core   +1 more source

Enzymatic Prenylation of Proteins and Peptides: From Cysteine S‐Prenylation to Tryptophan‐Selective Biocatalysis

Chemistry – A European Journal, EarlyView.
This review highlights biocatalytic prenylation as a versatile strategy for tailoring the functional properties of peptides and proteins. By comparing branched isoprenoids with linear lipids, we illustrate how specific prenyl architectures modulate the behaviors of lipidated proteins within membrane environments.
Daisuke Fujinami, Hikari Ozawa, Sohei Ito   +2 more
wiley   +1 more source