Sphingomyelinases: enzymology and membrane activity [PDF]
FEBS Letters, 2002 This paper reviews our present knowledge of sphingomyelinases as enzymes, and as enzymes acting on a membrane constituent lipid, sphingomyelin. Six types of sphingomyelinases are considered, namely acidic, secretory, Mg2+‐dependent neutral, Mg2+‐independent neutral, alkaline, and bacterial enzymes with both phospholipase C and sphingomyelinase activity.
Goñi, Félix M, Alonso, Alicia
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VSL#3 Probiotic Upregulates Intestinal Mucosal Alkaline Sphingomyelinase and Reduces Inflammation
Canadian Journal of Gastroenterology, 2008 BACKGROUND: Alkaline sphingomyelinase, an enzyme found exclusively in bile and the intestinal brush border, hydrolyzes sphingomyelin into ceramide, sphingosine and sphingosine-1-phosphate, thereby inducing epithelial apoptosis. Reduced levels of alkaline
Isaac Soo +9 more
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Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure. [PDF]
, 2012 Inflammation enhances the secretion of sphingomyelinases (SMases). SMases catalyze the hydrolysis of sphingomyelin into phosphocholine and ceramide.
Bosman, GJ +10 more
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Saposin D: A sphingomyelinase activator [PDF]
Biochemical and Biophysical Research Communications, 1988 Saposin D, a newly discovered heat-stable, 10 kDa glycoprotein, was isolated from Gaucher spleen and purified to homogeneity. Chemical sequencing from its amino terminus demonstrated colinearity between its amino acid sequence and the deduced amino acid sequence of the fourth domain of prosaposin, the precursor of saposin proteins.
S, Morimoto +3 more
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Neutral sphingomyelinase‐2 and cardiometabolic diseases [PDF]
Obesity Reviews, 2021 SummarySphingolipids, in particular ceramides, play vital role in pathophysiological processes linked to metabolic syndrome, with implications in the development of insulin resistance, pancreatic ß‐cell dysfunction, type 2 diabetes, atherosclerosis, inflammation, nonalcoholic steatohepatitis, and cancer.
Sardar Sindhu +6 more
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Lipid levels in sperm, eggs, and during fertilization in Xenopus laevis
Journal of Lipid Research, 2008 Critical developmental periods, such as fertilization, involve metabolic activation, membrane fusion events such as sperm-egg or plasma membrane-cortical granule merger, and production and hydrolysis of phospholipids.
Douglas W. Petcoff +2 more
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The Role of Sphingomyelin Breakdown in Measles Virus Immunmodulation [PDF]
, 2014 Measles virus (MV) efficiently causes generalized immunosuppression which accounts to a major extent for cases of measles-asscociated severe morbidity and mortality.
Avota, Elita +1 more
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Thematic Review Series: Sphingolipids. Nuclear sphingolipids: metabolism and signaling*
Journal of Lipid Research, 2008 Sphingolipids are most prominently expressed in the plasma membrane, but recent studies have pointed to important signaling and regulatory roles in the nucleus.
Robert W. Ledeen, Gusheng Wu
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Sphingomyelinase D from loxosceles laeta venom induces the expression of MMP7 in human keratinocytes: contribution to dermonecrosis [PDF]
, 2016 Envenomation by Loxosceles spider is characterized by the development of dermonecrosis. In previous studies, we have demonstrated that increased expression/secretion of matrix metalloproteinases 2 and 9, induced by Loxosceles intermedia venom Class 2 ...
Correa, Mara A. +4 more
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Re-Configuration of Sphingolipid Metabolism by Oncogenic Transformation
Biomolecules, 2014 The sphingolipids are one of the major lipid families in eukaryotes, incorporating a diverse array of structural variants that exert a powerful influence over cell fate and physiology. Increased expression of sphingosine kinase 1 (SPHK1), which catalyses
Anthony S. Don +2 more
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