Results 31 to 40 of about 23,449 (215)
Lipid levels in sperm, eggs, and during fertilization in Xenopus laevis
Journal of Lipid Research, 2008 Critical developmental periods, such as fertilization, involve metabolic activation, membrane fusion events such as sperm-egg or plasma membrane-cortical granule merger, and production and hydrolysis of phospholipids.
Douglas W. Petcoff +2 more
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Thematic Review Series: Sphingolipids. Nuclear sphingolipids: metabolism and signaling*
Journal of Lipid Research, 2008 Sphingolipids are most prominently expressed in the plasma membrane, but recent studies have pointed to important signaling and regulatory roles in the nucleus.
Robert W. Ledeen, Gusheng Wu
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Re-Configuration of Sphingolipid Metabolism by Oncogenic Transformation
Biomolecules, 2014 The sphingolipids are one of the major lipid families in eukaryotes, incorporating a diverse array of structural variants that exert a powerful influence over cell fate and physiology. Increased expression of sphingosine kinase 1 (SPHK1), which catalyses
Anthony S. Don +2 more
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Studies on the hydrophobic properties of sphingomyelinase [PDF]
Biochemical Journal, 1981 Crude liver lysosomal sphingomyelinase (EC 3.1.4.12) displays a heterogeneous electrofocusing profile. The majority of the enzyme resolves into two major components with acidic pI values near pH 4.6 and 4.8. Several additional minor peaks of activity are seen at more basic pH values (up to pH 8.0). In the presence of 0.1% Triton X-100 (or Cutscum), the
J W, Callahan +3 more
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Journal of Lipid Research, 2005 Interleukin-1β (IL-1β) is a major inducer of liver acute-phase protein expression in response to infection. Several transcription factors, including CCAAT/enhancer binding protein (C/EBP), are known mediators in this process, although the mechanisms by ...
Natalia V. Giltiay +4 more
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Ceramide as a Target of Marine Triterpene Glycosides for Treatment of Human Myeloid Leukemia
Marine Drugs, 2016 Acute myeloid leukemia (AML) is a heterogeneous myeloid clonal disorder exhibiting the accumulation of immature myeloid progenitors in the bone marrow and peripheral blood.
Seong-Hoon Yun +3 more
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Sphingomyelinase D, a novel probe for cellular sphingomyelin
Journal of Lipid Research, 2003 Sphingomyelin (SM) and free cholesterol (FC) are concentrated in the plasma membranes of eukaryotes; however, the physiological significance of their association is unclear.
Papasani V. Subbaiah +4 more
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Biomedicines, 2022 Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gastrointestinal tract, resulting in severe symptoms. At the moment, the goal of medical treatments is to reduce inflammation. IBD is treated with systemic anti-inflammatory
Tuula Penate Medina +7 more
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Journal of Lipid Research, 2006 We previously reported that human Niemann-Pick Disease type B (NPD-B) is associated with low HDL. In this study, we investigated the pathophysiology of this HDL deficiency by examining both HDL samples from NPD-B patients and nascent high density ...
Ching Yin Lee +8 more
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Chemistry and Physics of Lipids, 1999 Several physiologic and pathophysiologic processes in which sphingomyelinases (SMases) have been implicated may involve extracellular sphingomyelin (SM) hydrolysis. A candidate enzyme for these processes is a recently discovered SMase called secretory SMase, or S-SMase.
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