Results 51 to 60 of about 31,322 (227)

Increased sphingomyelin content impairs HDL biogenesis and maturation in human Niemann-Pick disease type B

Journal of Lipid Research, 2006
We previously reported that human Niemann-Pick Disease type B (NPD-B) is associated with low HDL. In this study, we investigated the pathophysiology of this HDL deficiency by examining both HDL samples from NPD-B patients and nascent high density ...
Ching Yin Lee, Alain Lesimple, Maxime Denis, Jérôme Vincent, Åsmund Larsen, Orval Mamer, Larbi Krimbou, Jacques Genest, Michel Marcil   +8 more
doaj   +1 more source

Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration

Journal of Lipid Research, 2013
Light-induced retinal degeneration (LIRD) in albino rats causes apoptotic photoreceptor cell death. Ceramide is a second messenger for apoptosis. We tested whether increases in ceramide mediate photoreceptor apoptosis in LIRD and if inhibition of ...
Hui Chen, Julie-Thu A. Tran, Annette Eckerd, Tuan-Phat Huynh, Michael H. Elliott, Richard S. Brush, Nawajes A. Mandal   +6 more
doaj   +1 more source

Sphingolipids: Effectors and Achilles Heals in Viral Infections?

Cells, 2021
As viruses are obligatory intracellular parasites, any step during their life cycle strictly depends on successful interaction with their particular host cells.
Sibylle Schneider-Schaulies, Fabian Schumacher, Dominik Wigger, Marie Schöl, Trushnal Waghmare, Jan Schlegel, Jürgen Seibel, Burkhard Kleuser   +7 more
doaj   +1 more source

Bioactive dairy ingredients for food and non-food applications [PDF]

, 2014
Lactobacilli and bifidobacteria are most commonly encountered in the dairy industries, either existing naturally in milk or inoculated as starters in fermented dairy products.
Gan, C., Liong, M.T., Peh, K., Tan, P.
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Acid Sphingomyelinase Deficiency Ameliorates Farber Disease [PDF]

International Journal of Molecular Sciences, 2019
Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan. We have recently reported a novel acid ceramidase deficiency model that mirrors the human disease closely.
Beckmann, Nadine, Becker, Katrin Anne, Kadow, Stephanie, Schumacher, Fabian, Kramer, Melanie, Kühn, Claudine, Schulz-Schaeffer, Walter J., Edwards, Michael J., Kleuser, Burkhard, Gulbins, Erich, Carpinteiro, Alexander   +10 more
openaire   +4 more sources

Blunted apoptosis of erythrocytes in mice deficient in the heterotrimeric G-protein subunit Gαi2 [PDF]

, 2016
Putative functions of the heterotrimeric G-protein subunit Gαi2-dependent signaling include ion channel regulation, cell differentiation, proliferation and apoptosis.
Birnbaumer, Lutz, Bissinger, Rosi, Chen, Hong, Fakhri, Hajar, Fehrenbacher, Birgit, Ghashghaeinia, Mehrdad, Honisch, Sabina, Lang, Elisabeth, Lang, Florian, Liu, Guilai, Liu, Guoxing, Lupescu, Adrian, Mack, Andreas F., Qadri, Syed M., Rexhepaj, Rexhep, Schaller, Martin, Singh, Yogesh, Umbach, Anja T., Zelenak, Christine   +18 more
core   +2 more sources

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Aggregation, fusion, and vesicle formation of modified low density lipoprotein particles: molecular mechanisms and effects on matrix interactions

Journal of Lipid Research, 2000
Initiation of atherosclerosis is characterized by accumulation of aggregates of small lipid droplets and vesicles in the extracellular matrix of the arterial intima.
Katariina Öörni, Markku O. Pentikäinen, Mika Ala-Korpela, Petri T. Kovanen   +3 more
doaj   +1 more source

Early Radiation Therapy Response Assessment Using Multi‐Scale Photoacoustic Imaging

Advanced Science, EarlyView.
Tomographic and mesoscopic photoacoustics capture intratumoural features of radioresistance and response. ABSTRACT There is a critical unmet clinical need to identify biomarkers that predict and detect radiation therapy (RT) response in cancer. Using the unique capabilities of multi‐scale photoacoustic imaging (PAI) to depict tumor oxygenation and ...
Thierry L. Lefebvre, Mariam‐Eleni Oraiopoulou, Ellie V. Bunce, Thomas R. Else, Lorna C. Wright, Monika A. Golinska, Lina Hacker, Cara Brodie, Steven Kupczak, Yi Cheng, Lisa Young, Paul W. Sweeney, Sarah E. Bohndiek   +12 more
wiley   +1 more source