Results 41 to 50 of about 23,449 (215)

-Independent Sphingomyelinase from Rat Brain [PDF]

, 2023
Sphingomyelinase (SMase) catalyzes ceramide production from sphingomyelin. Ceramides are critical in cellular responses such as apoptosis. They enhance mitochondrial outer membrane permeabilization (MOMP) through self-assembly in the mitochondrial outer ...
Shin, In Chul, Yongwei Piao, Seok Kyun Kim, Choi, Jong Min, Lee, Jae Hong, Jang, Ji Min, Jeong, Eui Man, Jong Min Choi, Fu, Zhicheng, Jung, Sung Yun, Jong Hoon Won, Kyong Hoon Ahn, In Chul Shin, Eui Man Jeong, Zhicheng Fu, Sung Yun Jung, Ji Min Jang, Dae Kyong Kim, Ahn, Kyong Hoon, Kim, Seok Kyun, Piao, Yongwei, Kim, Dae Kyong, Jae Hong Lee, Won, Jong Hoon   +23 more
core   +1 more source

Inhibition of de novo ceramide biosynthesis by FTY720 protects rat retina from light-induced degeneration

Journal of Lipid Research, 2013
Light-induced retinal degeneration (LIRD) in albino rats causes apoptotic photoreceptor cell death. Ceramide is a second messenger for apoptosis. We tested whether increases in ceramide mediate photoreceptor apoptosis in LIRD and if inhibition of ...
Hui Chen, Julie-Thu A. Tran, Annette Eckerd, Tuan-Phat Huynh, Michael H. Elliott, Richard S. Brush, Nawajes A. Mandal   +6 more
doaj   +1 more source

Sphingomyelinases: enzymology and membrane activity [PDF]

FEBS Letters, 2002
This paper reviews our present knowledge of sphingomyelinases as enzymes, and as enzymes acting on a membrane constituent lipid, sphingomyelin. Six types of sphingomyelinases are considered, namely acidic, secretory, Mg2+‐dependent neutral, Mg2+‐independent neutral, alkaline, and bacterial enzymes with both phospholipase C and sphingomyelinase activity.
Goñi, Félix M, Alonso, Alicia
openaire   +2 more sources

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis [PDF]

, 1996
Stress is believed to activate sphingomyelinase to generate ceramide, which serves as a second messenger in initiating the apoptotic response. Conclusive evidence for this paradigm, however, is lacking. In the present study, we used a genetic approach to
McLoughlin, Maureen, Schuchman, Edward H., Cordon-Cardo, Carlos, Peña, Louis A., Santana, Pino, Kolesnick, Richard, Haimovitz-Friedman, Adriana, Fuks, Zvi, Peña, Louis A, Martin, Seamus, Santana Delgado, María Del Pino, Green, Douglas, Schuchman, Edward H   +12 more
core   +1 more source

Sphingolipids: Effectors and Achilles Heals in Viral Infections?

Cells, 2021
As viruses are obligatory intracellular parasites, any step during their life cycle strictly depends on successful interaction with their particular host cells.
Sibylle Schneider-Schaulies, Fabian Schumacher, Dominik Wigger, Marie Schöl, Trushnal Waghmare, Jan Schlegel, Jürgen Seibel, Burkhard Kleuser   +7 more
doaj   +1 more source

Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia

Neurobiology of Disease
Loss-of-function mutations affecting the lysosomal protein progranulin are a leading cause of frontotemporal dementia. Progranulin mutations cause abnormalities in lysosomal lipid processing, particularly of sphingolipids, major components of neural cell
Nicholas R. Boyle, Stephanie N. Fox, Aniketh S. Tadepalli, Nicholas T. Seyfried, Thomas Kukar, Eliana M. Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant, Erik D. Roberson   +12 more
doaj   +1 more source

Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma [PDF]

, 2023
: Pancreatic adenocarcinoma (PDAC) is one of the most common cancers worldwide. Unfortunately, the prognosis of PDAC is rather poor, and for instance, in the USA, over 47,000 people die because of pancreatic cancer annually.
Wang J., Patel S. H., Turner K. M., Wilson G. C., Becker K. A., Ahmad S. A., Szabo I., Gulbins E., Xu K., Carpinteiro A.   +9 more
core   +1 more source

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

From Biological Mechanisms to Causal Inference: Quantitative Systems Pharmacology and Causal Frameworks in Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
Digital patients and in silico clinical trials offer new opportunities to advance pharmacological research, clinical development, and regulatory decision‐making by enabling the simulation of treatment effects prior to testing in patients. Among the most promising of these opportunities is the combined use of quantitative systems pharmacology (QSP) and ...
Thomas Klabunde, Ramon Hernandez, Piet H. van der Graaf, Tommaso Andreani   +3 more
wiley   +1 more source

Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases [PDF]

FEBS Letters, 2004
Sphingosylphosphocholine (SPC), the N‐deacylated form of sphingomyelin (SM), is a naturally occurring lipid mediator. However, little is known about the metabolism of SPC. We here report an in vitro assay system for SPC‐phospholipase C (PLC). Using this assay system, we demonstrated that nSMase1 and nSMase2, human neutral sphingomyelinases (SMases ...
Miura, Yukiko, Gotoh, Eriko, Nara, Futoshi, Nishijima, Masahiro, Hanada, Kentaro   +4 more
openaire   +2 more sources