Results 41 to 50 of about 31,322 (227)
Neuronal human BACE1 knock-in induces systemic diabetes in mice [PDF]
, 2016 Acknowledgements The authors thank S. Tammireddy (Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, UK) for technical support with the lipidomics component. Funding We would like to thank R.
Dekeryte, Ruta +12 more
core +4 more sources
Journal of Lipid Research, 2005 Interleukin-1β (IL-1β) is a major inducer of liver acute-phase protein expression in response to infection. Several transcription factors, including CCAAT/enhancer binding protein (C/EBP), are known mediators in this process, although the mechanisms by ...
Natalia V. Giltiay +4 more
doaj +1 more source
Biomedicines, 2022 Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gastrointestinal tract, resulting in severe symptoms. At the moment, the goal of medical treatments is to reduce inflammation. IBD is treated with systemic anti-inflammatory
Tuula Penate Medina +7 more
doaj +1 more source
Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia. [PDF]
, 2019 Cultured mouse peritoneal macrophages release large numbers of ~30-nm cholesterol-rich particles. Here, we show that those particles represent fragments of the plasma membrane that are pulled away and left behind during the projection and retraction of ...
Fong, Loren G +11 more
core +3 more sources
Acid sphingomyelinase in macrophage biology [PDF]
Cellular and Molecular Life Sciences, 2011 Macrophages play a central role in innate immune responses, in disposal of cholesterol, and in tissue homeostasis and remodeling. To perform these vital functions macrophages display high endosomal/lysosomal activities. Recent studies have highlighted that acid sphingomyelinase (ASMase), which generates ceramide from sphingomyelin, is involved in ...
Jean-Philip, Truman +3 more
openaire +2 more sources
Ceramide as a Target of Marine Triterpene Glycosides for Treatment of Human Myeloid Leukemia
Marine Drugs, 2016 Acute myeloid leukemia (AML) is a heterogeneous myeloid clonal disorder exhibiting the accumulation of immature myeloid progenitors in the bone marrow and peripheral blood.
Seong-Hoon Yun +3 more
doaj +1 more source
Role of sph2 Gene Regulation in Hemolytic and Sphingomyelinase Activities Produced by Leptospira interrogans. [PDF]
PLoS Neglected Tropical Diseases, 2015 Pathogenic members of the genus Leptospira are the causative agents of leptospirosis, a neglected disease of public and veterinary health concern. Leptospirosis is a systemic disease that in its severest forms leads to renal insufficiency, hepatic ...
Suneel A Narayanavari +4 more
doaj +1 more source
Chemistry and Physics of Lipids, 1999 Several physiologic and pathophysiologic processes in which sphingomyelinases (SMases) have been implicated may involve extracellular sphingomyelin (SM) hydrolysis. A candidate enzyme for these processes is a recently discovered SMase called secretory SMase, or S-SMase.
openaire +2 more sources
Sphingomyelinase D, a novel probe for cellular sphingomyelin
Journal of Lipid Research, 2003 Sphingomyelin (SM) and free cholesterol (FC) are concentrated in the plasma membranes of eukaryotes; however, the physiological significance of their association is unclear.
Papasani V. Subbaiah +4 more
doaj +1 more source
The role of inflammation in age-related disease. [PDF]
, 2013 The National Institutes of Health (NIH) Geroscience Interest Group (GSIG) sponsored workshop, The Role of Inflammation inAge-Related Disease, was held September 6th-7th, 2012 in Bethesda, MD.
Augustine, Alison Deckhut +9 more
core +2 more sources