Results 41 to 50 of about 18,841 (183)

Saposin D: A sphingomyelinase activator [PDF]

Biochemical and Biophysical Research Communications, 1988
Saposin D, a newly discovered heat-stable, 10 kDa glycoprotein, was isolated from Gaucher spleen and purified to homogeneity. Chemical sequencing from its amino terminus demonstrated colinearity between its amino acid sequence and the deduced amino acid sequence of the fourth domain of prosaposin, the precursor of saposin proteins.
Morimoto, Satoshi, Martin, Brian M., Kishimoto, Yasuo, O'Brien, John S.   +3 more
openaire   +3 more sources

Staphylococcus aureus β-hemolysin causes skin inflammation by acting as an agonist of epidermal growth factor receptor

Microbiology Spectrum
Staphylococcus aureus is a common cause of inflammatory skin diseases, with one of its virulence factors, β-hemolysin (Hlb), known to promote skin colonization. However, its direct involvement in skin inflammation is unclear. In this study, we identified
Yonggen Jia, Zhangchun Guan, Chenghua Liu, Minjun Huang, Jingjing Li, Jiannan Feng, Beifen Shen, Guang Yang   +7 more
doaj   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

A Curcumin‐Derived HSP70 Inhibitor Disrupts Lysosomal Function to Suppress Triple‐Negative Breast Cancer Progression

Cell Proliferation, EarlyView.
Novel curcumin‐derived M4 binds HSP70's ATPase domain, disrupting HSP70‐mediated lysosomes‐autophagy pathway to inhibit TNBC growth and metastasis, and synergizes with paclitaxel for potent combination therapy. ABSTRACT Structural modification of curcumin yielded a novel series of 1,4‐pentadien‐3‐one oxime ether derivatives, among which compound M4 ...
Zijian Li, Wanxia Wang, Yuxin Zhou, Tao Zeng, Jian Liu, Yingjie Qing, Xuan Han   +6 more
wiley   +1 more source

A lipid‐sensitive food choice behavior influences aging outcomes from a longevity‐promoting diet

The FEBS Journal, EarlyView.
C. elegans are exposed to a variety of bacteria in their natural environment and must be able to distinguish between beneficial and detrimental food sources. We show that C. elegans exposed to the bacterium from their natural habitat, Methylobacterium, disrupts lipid homeostasis, causing worms to avoid this bacterial species and choose the laboratory ...
Nicole L. Stuhr, Carmen M. Ramos, Chris D. Turner, Alexander A. Soukas, Sean P. Curran   +4 more
wiley   +1 more source

Thematic Review Series: Sphingolipids. ISC1 (inositol phosphosphingolipid-phospholipase C), the yeast homologue of neutral sphingomyelinases*

Journal of Lipid Research, 2008
Sphingolipid biosynthesis and breakdown in yeast share many homologies in their pathways with higher eukaryotes (Dickson, R. C. 1998. Sphingolipid functions in Saccharomyces cerevisiae: comparison to mammals. Annu. Rev. Biochem. 67: 27–48).
Nabil Matmati, Yusuf A. Hannun
doaj   +1 more source

Association Between the Root Canal Microbiome and Apical Lesion Size: An Observational Shotgun Metagenomic Study

International Endodontic Journal, EarlyView.
ABSTRACT Aim The aim was to characterize the taxonomic and functional composition of the microbiome involved in primary endodontic infections and to evaluate their association with the periapical lesion size using shotgun metagenomic sequencing. Methodology Samples from primary root canal infections diagnosed with apical periodontitis were analysed ...
Virginia Pérez‐Carrasco, David Uroz‐Torres, Ana Soriano‐Lerma, Miguel Soriano, Jose Antonio García‐Salcedo, Maria Teresa Arias‐Moliz   +5 more
wiley   +1 more source

Activation of Sphingomyelinase-Ceramide-Pathway in COVID-19 Purposes Its Inhibition for Therapeutic Strategies

Frontiers in Immunology, 2021
Effective treatment strategies for severe coronavirus disease (COVID-19) remain scarce. Hydrolysis of membrane-embedded, inert sphingomyelin by stress responsive sphingomyelinases is a hallmark of adaptive responses and cellular repair.
Murad Abusukhun, Murad Abusukhun, Martin S. Winkler, Stefan Pöhlmann, Stefan Pöhlmann, Onnen Moerer, Konrad Meissner, Björn Tampe, Heike Hofmann-Winkler, Michael Bauer, Michael Bauer, Markus H. Gräler, Markus H. Gräler, Markus H. Gräler, Ralf A. Claus, Ralf A. Claus   +15 more
doaj   +1 more source

Cytotoxicity Profiling of Tenacibaculum Extracellular Products on Chinook Salmon (Oncorhynchus tshawytscha) Gill Cell Line, OTgill1PFR

Journal of Fish Diseases, EarlyView.
ABSTRACT Tenacibaculosis is an important disease of marine fishes caused by bacteria of the genus Tenacibaculum. Pathogenic Tenacibaculum species or serotypes, including Tenacibaculum maritimum, T. dicentrarchi, T. finnmarkense and T. soleae, have been isolated from farmed Chinook salmon (Oncorhynchus tshawytscha) during disease outbreaks in Aotearoa ...
Bjorn Böhmert, Michael Algie, Karthiga Kumanan, Kate S. Hutson, Georgina C. Dowd   +4 more
wiley   +1 more source

High binding affinity of electronegative LDL to human aortic proteoglycans depends on its aggregation level[S]

Journal of Lipid Research, 2009
Electronegative LDL [LDL(−)] is an atherogenic subfraction of plasma LDL that has increased apolipoprotein E (apoE) and apoC-III content, high density, and increased susceptibility to aggregation.
Cristina Bancells, Sònia Benítez, Matti Jauhiainen, Jordi Ordóñez-Llanos, Petri T. Kovanen, Sandra Villegas, José Luis Sánchez-Quesada, Katariina O¨o¨rni   +7 more
doaj   +1 more source