Results 71 to 80 of about 23,449 (215)
Sphingolipid Metabolism and Neutral Sphingomyelinases [PDF]
, 2013 Sphingolipids are an important class of lipid molecules that play fundamental roles in our cells and body. Beyond a structural role, it is now clearly established that sphingolipids serve as bioactive signaling molecules to regulate diverse processes including inflammatory signaling, cell death, proliferation, and pain sensing. Sphingolipid metabolites
Michael V, Airola, Yusuf A, Hannun
openaire +2 more sources
Lysosomal sphingomyelinase is not solicited for apoptosis signaling
, 2000 International audienceABSTRACT Stress‐induced activation of an acidic sphingomyelinase leading to generation of ceramide, an important lipid mediator, has been associated with apoptosis; however, the implication of this hydrolase has been questioned. The
Gouazé, Valérie +23 more
core +1 more source
Multiplex analysis of sphingolipids using amine-reactive tags (iTRAQ)
Journal of Lipid Research, 2011 Ceramides play a crucial role in divergent signaling events, including differentiation, senescence, proliferation, and apoptosis. Ceramides are a minor lipid component in terms of content; thus, highly sensitive detection is required for accurate ...
Takuji Nabetani +8 more
doaj +1 more source
Arthritis Research & Therapy, 2022 Background Penfluridol, isolated from an FDA-approved small-molecule drug library as an inhibitor of tumor necrosis factor α (TNFα)-stimulated NF-κB activation, is clinically used to treat chronic schizophrenia and related disorders.
Yue-hong Chen +7 more
doaj +1 more source
Periodontology 2000, EarlyView.Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad +6 more
wiley +1 more source
Structure and Function of Sphingomyelinase
YAKUGAKU ZASSHI, 2009 Bacillus cereus is one that causes of opportunistic human infections. Sphingomyelinase produced by B. cereus is assumed a virulence factor for the infection. Sphingomyelinase from Bacillus cereus (Bc-SMase) is Mg(2+)-containing metalloenzyme. Bc-SMase is a family of neutral SMase (nSMase) and mimics the actions of the endogenous mammalian nSMase in ...
openaire +3 more sources
Identifikation neuer klinischer Anwendungen für Saure Sphingomyelinase Inhibitoren [PDF]
, 2017 Acid sphingomyelinase is a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin to ceramide. Acid sphingomyelinase/ceramide have been implicated in the pathogenesis of a number of different diseases.
Beckmann, Nadine
core
Cells, 2020 Changes in sphingolipid metabolism have been suggested to contribute to the pathophysiology of major depression. In this study, we investigated the activity of acid and neutral sphingomyelinases (ASM, NSM) and ceramidases (AC, NC), respectively, in ...
Iulia Zoicas +5 more
doaj +1 more source
ROLE OF CERAMIDE IN TRANSFERRIN RECEPTOR MOVEMENT IN THE PLANE OF THE PLASMA MEMBRANE [PDF]
Assiut Veterinary Medical Journal, 2010 After ligation with transferrin (Tf), transferrin receptor (TfR) is aggregated on cell surface in clathrin coated pits and then internalized into the cell.
RANA ALAWADHI, A-B.M. ABDEL-SHAKOR
doaj +1 more source
Periodontitis and metabolic dysfunction‐associated steatotic liver disease
Periodontology 2000, EarlyView.Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon +6 more
wiley +1 more source