Results 21 to 30 of about 8,477 (148)

Neutral sphingomyelinase 2: A promising drug target for CNS disease. [PDF]

Adv Pharmacol
Neutral sphingomyelinase 2 (nSMase2), encoded by the SMPD3 gene, is a pivotal enzyme in sphingolipid metabolism, hydrolyzing sphingomyelin to produce ceramide, a bioactive lipid involved in apoptosis, inflammation, membrane structure, and extracellular vesicle (EV) biogenesis.
Huang M, Stremlau M, Zavras J, Zivko C, Thomas AG, Pietri P, Machairaki V, Slusher BS.   +7 more
europepmc   +3 more sources

The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells. [PDF]

Int J Mol Sci
The accumulation of lipid droplets (LDs) and ceramides (Cer) is linked to non-alcoholic fatty liver disease (NAFLD), regularly co-existing with type 2 diabetes and decreased immune function. Chronic inflammation and increased disease severity in viral infections are the hallmarks of the obesity-related immunopathology.
Schempp R, Eilts J, Schöl M, Grijalva Yépez MF, Fekete A, Wigger D, Schumacher F, Kleuser B, van Ham M, Jänsch L, Sauer M, Avota E.   +11 more
europepmc   +3 more sources

Regulation of brain aging by neutral sphingomyelinase 2 [PDF]

, 2021
Abstract We have shown that deficiency of neutral sphingomyelinase 2 (nSMase2), an enzyme generating the sphingolipid ceramide, improves memory in adult mice. Here, we performed sphingolipid and RNA-seq analyses on the cortex from 10 month-old nSMase2-deficient ( fro/fro ) and ...
Zhihui Zhu, Zainuddin Quadri, Simone M. Crivelli, Ahmed Elsherbini, Liping Zhang, Priyanka Tripathi, Haiyan Qin, Emily Roush, Stefka D. Spassieva, Mariana Nikolova-Karakashian, Timothy S. McClintock, Erhard Bieberich   +11 more
openaire   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Analysis of membrane topology of neutral sphingomyelinase 2 [PDF]

FEBS Letters, 2007
Neutral sphingomyelinase 2 (nSMase2), which has two hydrophobic segments at its NH2‐terminus, plays an important role in ceramide‐mediated cell regulation. Here, we investigated the membrane topology of nSMase2. When a double‐tagged nSMase2 at both the NH2 and COOH termini, was overexpressed in MCF‐7 cells, the signals from both tags were detected in ...
Tani, Motohiro, Hannun, Yusuf A.
openaire   +2 more sources

Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease. [PDF]

J Med Chem, 2020
Neutral sphingomyelinase 2 (nSMase2) catalyzes the cleavage of sphingomyelin to phosphorylcholine and ceramide, an essential step in the formation and release of exosomes from cells that is critical for intracellular communication. Chronic increase of brain nSMase2 activity and related exosome release have been implicated in various pathological ...
Šála M, Hollinger KR, Thomas AG, Dash RP, Tallon C, Veeravalli V, Lovell L, Kögler M, Hřebabecký H, Procházková E, Nešuta O, Donoghue A, Lam J, Rais R, Rojas C, Slusher BS, Nencka R.   +16 more
europepmc   +5 more sources

Src Regulates Cigarette Smoke–Induced Ceramide Generation via Neutral Sphingomyelinase 2 in the Airway Epithelium [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2015
Simon Vu, Samuel Chung, Simone Filosto   +2 more
exaly   +2 more sources

Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes. [PDF]

Adv Biol Regul, 2015
Our understanding of the functions of ceramide signaling has advanced tremendously over the past decade. In this review, we focus on the roles and regulation of neutral sphingomyelinase 2 (nSMase2), an enzyme that generates the bioactive lipid ceramide through the hydrolysis of the membrane lipid sphingomyelin.
Shamseddine AA, Airola MV, Hannun YA.
europepmc   +4 more sources

Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice

Pharmaceutics, 2022
Alzheimer’s disease (AD) is characterized by the progressive accumulation of amyloid-β and hyperphosphorylated tau (pTau), which can spread throughout the brain via extracellular vesicles (EVs).
Carolyn Tallon, Benjamin J. Bell, Anjali Sharma, Arindom Pal, Medhinee M. Malvankar, Ajit G. Thomas, Seung-Wan Yoo, Kristen R. Hollinger, Kaleem Coleman, Elizabeth L. Wilkinson, Sujatha Kannan, Norman J. Haughey, Rangaramanujam M. Kannan, Rana Rais, Barbara S. Slusher   +14 more
doaj   +1 more source

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model

Translational Neurodegeneration, 2023
Background Cognitive decline in Alzheimer’s disease (AD) is associated with hyperphosphorylated tau (pTau) propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EVs). EV biogenesis is triggered by ceramide
Carolyn Tallon, Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G. Thomas, Kristen R. Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R. Joe, Rana Rais, Norman J. Haughey, Dimitrios Kapogiannis, Barbara S. Slusher   +16 more
doaj   +1 more source