Results 11 to 20 of about 8,477 (148)

Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls [PDF]

International Journal of COPD, 2016
Simon R Lea,1,* Hannah J Metcalfe,1,* Jonathan Plumb,1 Christian Beerli,2 Chris Poll,3 Dave Singh,1 Katharine H Abbott-Banner3 1Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre,
Lea SR, Metcalfe HJ, Plumb J, Beerli C, Poll C, Singh D, Abbott-Banner KH   +6 more
doaj   +8 more sources

Vascular Smooth Muscle Cell Neutral Sphingomyelinase 2 in the Release of Exosomes and Vascular Calcification [PDF]

International Journal of Molecular Sciences, 2022
Vascular calcification (VC) is the pathological precipitation of calcium salts in the walls of blood vessels. It is a risk factor for cardiovascular events and their associated mortality. VC can be observed in a variety of cardiovascular diseases and is most prominent in diseases that are associated with dysregulated mineral homeostasis such as in ...
Leon Schurgers, Chris Reutelingsperger, Nasim Bahram Sangani   +2 more
exaly   +5 more sources

Role of Neutral Sphingomyelinase-2 (NSM 2) in the Control of T Cell Plasma Membrane Lipid Composition and Cholesterol Homeostasis [PDF]

Frontiers in Cell and Developmental Biology, 2019
The activity of neutral sphingomyelinase-2 (NSM2) to catalyze the conversion of sphingomyelin (SM) to ceramide and phosphocholine at the cytosolic leaflet of plasma membrane (PM) is important in T cell receptor (TCR) signaling.
Charlene Börtlein, Fabian Schumacher, Fabian Schumacher, Burkhard Kleuser, Lars Dölken, Elita Avota   +5 more
doaj   +2 more sources

Hyperosmolarity-induced lipid droplet formation depends on ceramide production by neutral sphingomyelinase 2 [PDF]

Journal of Lipid Research, 2012
Hyperosmolarity (HO) imposes a remarkable stress on membranes, especially in tissues in direct contact with the external environment. Our efforts were focused on revealing stress-induced lipid changes that precede the inflammatory cytokine response in ...
Alexandra Robciuc, Tuulia Hyötyläinen, Matti Jauhiainen, Juha M. Holopainen   +3 more
doaj   +6 more sources

Neutral sphingomyelinase-2 and cardiometabolic diseases. [PDF]

Obes Rev, 2021
SummarySphingolipids, in particular ceramides, play vital role in pathophysiological processes linked to metabolic syndrome, with implications in the development of insulin resistance, pancreatic ß‐cell dysfunction, type 2 diabetes, atherosclerosis, inflammation, nonalcoholic steatohepatitis, and cancer.
Sindhu S, Leung YH, Arefanian H, Madiraju SRM, Al-Mulla F, Ahmad R, Prentki M.   +6 more
europepmc   +4 more sources

Neutral sphingomyelinase 2 is required for HIV-1 maturation. [PDF]

Proc Natl Acad Sci U S A, 2023
HIV-1 assembly occurs at the inner leaflet of the plasma membrane (PM) in highly ordered membrane microdomains. The size and stability of membrane microdomains is regulated by activity of the sphingomyelin hydrolase neutral sphingomyelinase 2 (nSMase2) that is localized primarily to the inner leaflet of the PM.
Waheed AA, Zhu Y, Agostino E, Naing L, Hikichi Y, Soheilian F, Yoo SW, Song Y, Zhang P, Slusher BS, Haughey NJ, Freed EO.   +11 more
europepmc   +3 more sources

Mechanism of Rapid Nuclear Factor-E2-Related Factor 2 (Nrf2) Activation via Membrane-Associated Estrogen Receptors: Roles of NADPH Oxidase 1, Neutral Sphingomyelinase 2 and Epidermal Growth Factor Receptor (EGFR) [PDF]

Antioxidants, 2019
Membrane-associated estrogen receptors (ER)-α36 and G protein-coupled estrogen receptor (GPER) play important roles in the estrogen’s rapid non-genomic actions including stimulation of cell proliferation.
Tetsuro Ishii, Eiji Warabi
doaj   +2 more sources

Inhibition of neutral sphingomyelinase 2 promotes remyelination. [PDF]

Sci Adv, 2020
Targeting a sphingomyelin hydrolase improves the structure of remyelinated fibers in a mouse model of multiple sclerosis.
Yoo SW, Agarwal A, Smith MD, Khuder SS, Baxi EG, Thomas AG, Rojas C, Moniruzzaman M, Slusher BS, Bergles DE, Calabresi PA, Haughey NJ.   +11 more
europepmc   +4 more sources

Staying sane in the membrane: Neutral sphingomyelinase 2 as a master regulator of plasma membrane ceramide [PDF]

Journal of Lipid Research
Zainuddin Quadri, Erhard Bieberich
doaj   +2 more sources

Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease. [PDF]

ACS Chem Biol, 2020
We report the discovery of a novel class of compounds that function as dual inhibitors of the enzymes neutral sphingomyelinase-2 (nSMase2) and acetylcholinesterase (AChE). Inhibition of these enzymes provides a unique strategy to suppress the propagation of tau pathology in the treatment of Alzheimer's disease (AD).
Bilousova T, Simmons BJ, Knapp RR, Elias CJ, Campagna J, Melnik M, Chandra S, Focht S, Zhu C, Vadivel K, Jagodzinska B, Cohn W, Spilman P, Gylys KH, Garg NK, John V.   +15 more
europepmc   +6 more sources