Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation. [PDF]
PLoS ONE, 2010 BACKGROUND:Sphingomyelin hydrolysis in response to stress-inducing agents, and subsequent ceramide generation, are implicated in various cellular responses, including apoptosis, inflammation and proliferation, depending on the nature of the different ...
Raphael Devillard +8 more
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Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. [PDF]
PLoS ONE, 2015 Ceramide is a bioactive lipid that plays an important role in stress responses leading to apoptosis, cell growth arrest and differentiation. Ceramide production is due in part to sphingomyelin hydrolysis by sphingomyelinases.
Mariana Figuera-Losada +11 more
doaj +1 more source
Novel Pyrazolo[1,5-<i>a</i>]pyrimidine-3,5-diamines as nSMase2 Inhibitors. [PDF]
ACS Med Chem LettThis patent highlights novel pyrazolo[1,5-a]pyrimidine-3,5-diamines as neutral sphingomyelinase 2 (nSMase2) inhibitors. It provides detailed information on pyrazolo[1,5-a]pyrimidine-3,5-diamine compounds, their pharmaceutical composition, use, and potential therapeutic applications for nSMase2-related diseases.
Rong J, Liang SH.
europepmc +3 more sources
Neurobiology of Disease, 2022 People living with HIV (PLH) have significantly higher rates of cognitive impairment (CI) and major depressive disorder (MDD) versus the general population.
Xiaolei Zhu +13 more
doaj +1 more source
HMGB1 Induces Secretion of Matrix Vesicles by Macrophages to Enhance Ectopic Mineralization. [PDF]
PLoS ONE, 2016 Numerous clinical conditions have been linked to ectopic mineralization (EM). This process of pathological biomineralization is complex and not fully elucidated, but thought to be started within matrix vesicles (MVs).
Qiang Chen +8 more
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Cells, 2023 Clinical trials have shown that electric stimulation (ELSM) using either cardiac resynchronization therapy (CRT) or cardiac contractility modulation (CCM) approaches is an effective treatment for patients with moderate to severe heart failure, but the ...
Haitao Zhang +8 more
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ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation[S]
Journal of Lipid Research, 2016 Neutral sphingomyelinase-2 (nSMase2) is a key ceramide-producing enzyme in cellular stress responses. While many posttranslational regulators of nSMase2 are known, emerging evidence suggests a more protracted regulation of nSMase2 at the transcriptional ...
Christopher J. Clarke +5 more
doaj +1 more source
Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease
JCI Insight, 2021 IL-33 is a key mediator of chronic airway disease driven by type 2 immune pathways, yet the nonclassical secretory mechanism for this cytokine remains undefined.
Ella Katz-Kiriakos +12 more
doaj +1 more source
Impact of HepG2 Cells Glutathione Depletion on Neutral Sphingomyelinases mRNA Levels and Activity
Current Issues in Molecular Biology, 2023 Liver cancer is a prevalent form of cancer worldwide. While research has shown that increasing sphingomyelin (SM) hydrolysis by activating the cell surface membrane-associated neutral sphingomyelinase 2 (nSMase2) can control cell proliferation and ...
Marie Gamal +3 more
doaj +1 more source
Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance Ceramide is a bioactive lipid involved in numerous cellular functions and disease states that are critically dependent on its site of generation. nSMase2 generates ceramide at the inner leaflet of the plasma membrane and is a therapeutic target for cancer and neurological disorders.
Michael V, Airola +10 more
openaire +2 more sources