Results 21 to 30 of about 1,883 (170)

From physical impact to biological information flow: shock wave regulation of extracellular vesicles mediated tissue repair [PDF]

Frontiers in Cell and Developmental Biology
Shock wave is a tunable pulsed mechanical stimulus that may modulate cellular behavior and tissue microenvironments during repair. However, how localized and transient mechanical inputs are translated into sustained paracrine or remote reparative ...
Shengchao Zhang, Shengchao Zhang, Yuling Gao, Yuling Gao, Jiaqi Zhou, Jiaqi Zhou, Tong Li, Tong Li, Jingwen Liu, Jingwen Liu, Lan Yang, Lan Yang, Qipei Qiao, Qipei Qiao, Xiaoyang Gong, Xiaoyang Gong, Yong Liu, Yong Liu   +17 more
doaj   +2 more sources

Inhibiting Extracellular Vesicle Release from Human Cardiosphere Derived Cells with Lentiviral Knockdown of nSMase2 Differentially Effects Proliferation and Apoptosis in Cardiomyocytes, Fibroblasts and Endothelial Cells In Vitro.

PLoS ONE, 2016
Numerous studies have shown a beneficial effect of cardiosphere-derived cell (CDC) therapy on regeneration of injured myocardium. Paracrine signaling by CDC secreted exosomes may contribute to improved cardiac function.
Jennifer K Lang, Rebeccah F Young, Hashmat Ashraf, John M Canty   +3 more
doaj   +2 more sources

GW4869 Depletes Macrophages and Increases Number of Extracellular Vesicles in Murine Peritoneal Cavity Fluid. [PDF]

J Extracell Biol
ABSTRACT Pharmacological strategies to modulate extracellular vesicle (EV) release in vivo are gaining traction, yet their broader effects on local immune microenvironments remain unclear. In this study, we assessed how repeated intraperitoneal (i.p.) dosing of the neutral sphingomyelinase inhibitor GW4869 reshapes the peritoneal cavity.
Gudbergsson JM, Gobira PH, Grassi-Oliveira R, Etzerodt A.   +3 more
europepmc   +2 more sources

Empagliflozin-pretreated BMSC exosomes attenuate myocardial ischemia-reperfusion injury by enhancing atad3a/pink1-dependent mitophagy [PDF]

Stem Cell Research & Therapy
Background and objectives Mounting evidence demonstrates that exosomes derived from mesenchymal stem cells (MSCs) can mitigate myocardial ischemia-reperfusion injury (MIRI).
Yuling Jing, Ying Cai, Qiuting Li, Zaiyong Zheng, Haiqiong Yang, Yang Yu, Chunxiang Zhang   +6 more
doaj   +2 more sources

Regulated translocation of neutral sphingomyelinase-2 to the plasma membrane drives insulin resistance in steatotic hepatocytes

Journal of Lipid Research, 2023
Obesity-associated diabetes is linked to the accumulation of ceramide in various organs, including the liver. The exact mechanisms by which ceramide contributes to diabetic pathology are unclear, but one proposed scenario is that ceramide accumulation ...
S. El-Amouri, A. Karakashian, E. Bieberich, M. Nikolova-Karakashian   +3 more
doaj   +1 more source

Senescent Cell‐Derived Extracellular Vesicles in Therapy‐Induced Senescence: Immune Remodelling and Emerging Links to Mitochondrial Stress in Cancer [PDF]

J Extracell Biol
ABSTRACT Cancer therapy can induce cellular senescence and remodel the tumour microenvironment through the senescence‐associated secretory phenotype (SASP), including its membrane‐enclosed component, senescent cell‐derived extracellular vesicles (senEVs). This review summarizes senEV biogenesis, cargo‐dependent functions, and immune‐remodelling effects
Qian Y, Weng Z, Li N, Zhou Y, Pei H.
europepmc   +2 more sources

Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV

Neurobiology of Disease, 2022
People living with HIV (PLH) have significantly higher rates of cognitive impairment (CI) and major depressive disorder (MDD) versus the general population.
Xiaolei Zhu, Kristen R. Hollinger, Yiyao Huang, Alejandra Borjabad, Boe-Hyun Kim, Tanina Arab, Ajit G. Thomas, Mohammed Moniruzzaman, Lyndah Lovell, Andrey Turchinovich, Kenneth W. Witwer, David J. Volsky, Norman J. Haughey, Barbara S. Slusher   +13 more
doaj   +1 more source

Development of a FRET-Based Assay for Human Neutral Sphingomyelinase 2. [PDF]

Biochemistry
Neutral sphingomyelinase 2 (nSMase2) is a membrane-bound enzyme that hydrolyzes sphingomyelin (SM) into ceramide and phosphocholine. By generating the bioactive lipid ceramide, nSMase2 plays a critical role in cell stress responses and in regulating ...
Aywa KM, Kappe C, Ghandour B, Gao S, Arenz C, Hannun YA, Airola MV.   +6 more
europepmc   +2 more sources

Novel Pyrazolo[1,5-<i>a</i>]pyrimidine-3,5-diamines as nSMase2 Inhibitors. [PDF]

ACS Med Chem Lett
This patent highlights novel pyrazolo[1,5-a]pyrimidine-3,5-diamines as neutral sphingomyelinase 2 (nSMase2) inhibitors. It provides detailed information on pyrazolo[1,5-a]pyrimidine-3,5-diamine compounds, their pharmaceutical composition, use, and potential therapeutic applications for nSMase2-related diseases.
Rong J, Liang SH.
europepmc   +3 more sources

HMGB1 Induces Secretion of Matrix Vesicles by Macrophages to Enhance Ectopic Mineralization. [PDF]

PLoS ONE, 2016
Numerous clinical conditions have been linked to ectopic mineralization (EM). This process of pathological biomineralization is complex and not fully elucidated, but thought to be started within matrix vesicles (MVs).
Qiang Chen, Jun-Jie Bei, Chuan Liu, Shi-Bin Feng, Wei-Bo Zhao, Zhou Zhou, Zheng-Ping Yu, Xiao-Jun Du, Hou-Yuan Hu   +8 more
doaj   +1 more source