Results 31 to 40 of about 1,883 (170)

Electrical Stimulation Increases the Secretion of Cardioprotective Extracellular Vesicles from Cardiac Mesenchymal Stem Cells

Cells, 2023
Clinical trials have shown that electric stimulation (ELSM) using either cardiac resynchronization therapy (CRT) or cardiac contractility modulation (CCM) approaches is an effective treatment for patients with moderate to severe heart failure, but the ...
Haitao Zhang, Yan Shen, Il-man Kim, Yutao Liu, Jingwen Cai, Adam E. Berman, Kent R. Nilsson, Neal L. Weintraub, Yaoliang Tang   +8 more
doaj   +1 more source

ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation [PDF]

Journal of Lipid Research, 2016
Neutral sphingomyelinase-2 (nSMase2) is a key ceramide-producing enzyme in cellular stress responses. While many posttranslational regulators of nSMase2 are known, emerging evidence suggests a more protracted regulation of nSMase2 at the transcriptional level.
Christopher J. Clarke, Achraf A. Shamseddine, Joseph J. Jacob, Gabrielle Khalife, Tara A. Burns, Yusuf A. Hannun   +5 more
openaire   +3 more sources

Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease

JCI Insight, 2021
IL-33 is a key mediator of chronic airway disease driven by type 2 immune pathways, yet the nonclassical secretory mechanism for this cytokine remains undefined.
Ella Katz-Kiriakos, Deborah F. Steinberg, Colin E. Kluender, Omar A. Osorio, Catie Newsom-Stewart, Arjun Baronia, Derek E. Byers, Michael J. Holtzman, Dawn Katafiasz, Kristina L. Bailey, Steven L. Brody, Mark J. Miller, Jennifer Alexander-Brett   +12 more
doaj   +1 more source

Impact of HepG2 Cells Glutathione Depletion on Neutral Sphingomyelinases mRNA Levels and Activity

Current Issues in Molecular Biology, 2023
Liver cancer is a prevalent form of cancer worldwide. While research has shown that increasing sphingomyelin (SM) hydrolysis by activating the cell surface membrane-associated neutral sphingomyelinase 2 (nSMase2) can control cell proliferation and ...
Marie Gamal, Hatem Tallima, Hassan M. E. Azzazy, Anwar Abdelnaser   +3 more
doaj   +1 more source

Biogenesis of JC polyomavirus associated extracellular vesicles

Journal of Extracellular Biology, 2022
JC polyomavirus (JCPyV) is a small, non‐enveloped virus that persists in the kidney in about half the adult population. In severely immune‐compromised individuals JCPyV causes the neurodegenerative disease progressive multifocal leukoencephalopathy (PML)
Jenna Morris‐Love, Bethany A. O'Hara, Gretchen V. Gee, Aisling S. Dugan, Ryan S. O'Rourke, Brandon E. Armstead, Benedetta Assetta, Sheila A. Haley, Walter J. Atwood   +8 more
doaj   +1 more source

Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL

Redox Biology, 2015
The neutral type 2 sphingomyelinase (nSMase2) hydrolyzes sphingomyelin and generates ceramide, a major bioactive sphingolipid mediator, involved in growth arrest and apoptosis.
Sandra Garoby-Salom, Myriam Rouahi, Elodie Mucher, Nathalie Auge, Robert Salvayre, Anne Negre-Salvayre   +5 more
doaj   +1 more source

PAR1 and PAR4 exert opposite effects on tumor growth and metastasis of esophageal squamous cell carcinoma via STAT3 and NF-κB signaling pathways

Cancer Cell International, 2021
Background Esophageal carcinogenesis is a multifactorial process in which genetic and environmental factors interact to activate intracellular signals, leading to the uncontrolled survival and growth of esophageal squamous cell carcinoma (ESCC) cells ...
Jia Zhao, Guangyu Jin, Xudong Liu, Kai Wu, Yang Yang, Zhanfeng He, Donglei Liu, Chunyang Zhang, Dengyan Zhu, Jia Jiao, Xiangnan Li, Song Zhao   +11 more
doaj   +1 more source

Annexin II-dependent actin remodelling evoked by hydrogen peroxide requires the metalloproteinase/sphingolipid pathway

Redox Biology, 2015
Actin remodeling is a dynamic process associated with cell shape modification occurring during cell cycle and proliferation. Oxidative stress plays a role in actin reorganization via various systems including p38MAPK.
Christel Cinq-Frais, Christelle Coatrieux, Aude Savary, Romina D’Angelo, Corinne Bernis, Robert Salvayre, Anne Nègre-Salvayre, Nathalie Augé   +7 more
doaj   +1 more source

Increased liver tumor formation in neutral sphingomyelinase-2-deficient mice

Journal of Lipid Research, 2018
Sphingolipids are key signaling lipids in cancer. Genome-wide studies have identified neutral SMase-2 (nSMase2), an enzyme generating ceramide from SM, as a potential repressor for hepatocellular carcinoma.
Liansheng Zhong, Ji Na Kong, Michael B. Dinkins, Silvia Leanhart, Zhihui Zhu, Stefka D. Spassieva, Haiyan Qin, Hsuan-Pei Lin, Ahmed Elsherbini, Rebecca Wang, Xue Jiang, Mariana Nikolova-Karakashian, Guanghu Wang, Erhard Bieberich   +13 more
doaj   +1 more source

Bioglass enhances the production of exosomes and improves their capability of promoting vascularization

Bioactive Materials, 2021
Recently, exosomes have been extensively applied in tissue regeneration. However, their practical applications are severely restricted by the limited exosome secretion capability of cells.
Zhi Wu, Dan He, Haiyan Li
doaj   +1 more source