Results 51 to 60 of about 1,596 (140)

Identification of miR‐150‐5p in Human Amniotic Membrane Mesenchymal Cell‐Derived Extracellular Vesicles as a Novel Mechanism Driving Cardioprotection

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
Human amniotic membrane mesenchymal stem cells (hAMSCs) provide significant cardioprotection following myocardial ischemia/reperfusion injury. They improve cardiac function and reduce fibrosis by modulating the MIAT/miR‐150‐5p/HOXA4 signalling axis.
Nunzio Alcharani, Laura Tesoro, Javier Díez‐Mata, José Luis Zamorano, Marta Saura, Maite Iglesias, Carlos Zaragoza   +6 more
wiley   +1 more source

中性鞘磷脂酶2/神经酰胺调节高磷高钙诱导的血管平滑肌细胞成骨样分化和钙化

Zhongshan Daxue xuebao. Yixue kexue ban, 2018
： 【目的】阐明nSMase2是否调控高磷高钙诱导的血管平滑肌细胞钙化。【方法】采用人血管平滑肌细 胞钙化体外模型，用高磷高钙诱导血管平滑肌细胞钙化。分别用鞘磷脂酶抑制剂GW4869和siRNA干扰敲低 nSMase2 处理血管平滑肌细胞，检测骨相关蛋白 BMP2、Runx2、Osterix 的表达和细胞钙化程度。【结果】在细胞 钙化过程中 nSMase2 的表达水平和神经酰胺的含量增高 ...
梁青春, 陈燕亭, 陆立鹤
doaj  

Look Who Is Talking: Extracellular Vesicles as Mediators of Intercellular and Interorgan Communication

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Extracellular vesicles (EVs) mediate intercellular and interorgan communication during both physiological and pathological conditions. EVs include exosomes, ectosomes, and apoptotic bodies and contain bioactive molecules. EVs are delivered to proximal cells or can travel in bodily fluids and reach distant organs, where they trigger a response from the ...
Michela Saviana, Giulia Romano, Daniel del Valle‐Morales, Mario Acunzo, Patrick Nana‐Sinkam   +4 more
wiley   +1 more source

Glucocorticoids regulate small extracellular vesicle release via activation of nSMase2

Journal of Cell Science
ABSTRACT Glucocorticoid (GC) steroid hormones mediate the stress response, which requires dynamic communication between brain regions to enable an organism to react to and overcome perceived stressors. While many effects of GCs on the brain have been well-studied, little is known about whether and how GCs regulate brain cell–cell ...
Mia Burke, Clarissa Waites
openaire   +3 more sources

Novel insights into extracellular vesicles: An update on biomolecules, immunomodulation and clinical strategies in skin melanoma

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
Extracellular vesicles mediate melanoma progression by transferring biomolecules (proteins, nucleic acids) that reshape the tumour microenvironment, promote immune evasion and drive metastasis. They also serve as diagnostic biomarkers and engineered therapeutic carriers for targeted therapy.
Junshu Li, Wencheng Zhou, Ying Cen, Yong Qing   +3 more
wiley   +1 more source

Inhibiting Extracellular Vesicle Release from Human Cardiosphere Derived Cells with Lentiviral Knockdown of nSMase2 Differentially Effects Proliferation and Apoptosis in Cardiomyocytes, Fibroblasts and Endothelial Cells In Vitro.

PLoS ONE, 2016
Numerous studies have shown a beneficial effect of cardiosphere-derived cell (CDC) therapy on regeneration of injured myocardium. Paracrine signaling by CDC secreted exosomes may contribute to improved cardiac function.
Jennifer K Lang, Rebeccah F Young, Hashmat Ashraf, John M Canty   +3 more
doaj   +1 more source

Molecular crosstalk via exosomes in lung cancer progression

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
“Molecular and theranostics roles of exosomes in Lung Cancer.” Abstract Exosomes play a critical role in lung cancer metastasis, facilitating tumor progression through intercellular communication between cancer cells and the tumor microenvironment. These nanosized extracellular vesicles carry bioactive molecules such as proteins, nucleic acids, and ...
Rajib Dhar, Vinoth Kumarasamy, Brian G. Oliver, Vetriselvan Subramaniyan   +3 more
wiley   +1 more source

Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi [PDF]

Journal of Neuroinflammation, 2013
Ceramide accumulation is considered a contributing factor to neuronal dysfunction and damage. However, the underlying mechanisms that occur following ischemic insult are still unclear.In the present study, we established cerebral ischemia models using four-vessel occlusion and oxygen-glucose deprivation methods.
Gu, LiZe, Huang, BaoSheng, Shen, Wei, Gao, Li, Ding, ZhengZheng, Wu, HuiWen, Guo, Jun   +6 more
openaire   +2 more sources

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, Volume 26, Issue 2-3, Page 33-80, February 2026.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

PD‐L1 on Tumor‐Derived Extracellular Vesicles Induces CD8+ T Cell Terminal Exhaustion and Mediates Anti‐PD‐1 Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Immunotherapy fails in head and neck squamous cell carcinoma (HNSCC) due to terminally exhausted T (Texterm) cells. Tumor‐derived PD‐L1+ extracellular vesicles promote CD8‐Texterm cells differentiation by upregulating BATF. Stromal Texterm density serves as a potent biomarker for predicting immunotherapy resistance, highlighting a novel EV‐mediated ...
Ruihua Fang, Bixue Huang, Yun Li, Zhimou Cai, Yicheng Deng, Xiaoqing Cen, Wei Sun, Jinhong Zhang, Zhenglin Xu, Wenbin Guo, Yi Lyu, Shiyun Luo, Zhesheng Chen, Kexing Lyu, Weiping Wen, Wenbin Lei   +15 more
wiley   +1 more source