Results 61 to 70 of about 1,596 (140)

The physiological and pathological effects of sphingolipid metabolism and signaling in the central nervous system

Brain Pathology, Volume 36, Issue 1, January 2026.
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li, Haoying He, Ejuan Zhang, Fengjiao Hu, Zhuo Wang, Jian Xu, Mengliu Zeng, Biwen Peng   +7 more
wiley   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, Volume 5, Issue 6, December 2025.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source

Microglial‐targeted nSMase2 inhibitor fails to reduce tau spread in the animal model of Alzheimer’s disease [PDF]

Alzheimers Dement
AbstractBackgroundCognitive decline associated with Alzheimer’s disease (AD) correlates with hyperphosphorylated tau (pTau) propagating between neurons along networks connected by synapses. It has been hypothesized this transcellular transmission occurs partially by extracellular vesicles (EVs).
Huang M, Tallon C, Zhu X, Huizar K, Piccirillo S, Thomas A, Tenora L, Liyanage W, Roda F, Gualerzi A, Kannan R, Bedoni M, Rais R, Slusher B.   +13 more
europepmc   +2 more sources

Challenging the conventional wisdom: Re‐evaluating Smpd3's role in extracellular vesicle biogenesis

Journal of Extracellular Biology
Extracellular vesicles (EVs) are pivotal in intercellular communication, impacting diverse physiological and pathological processes. Current in vitro EV biogenesis studies often utilize pharmacological inhibitors, inducing off‐target effects and ...
Marlies Burgelman, Pieter Dujardin, Anthony Willems, Tino Hochepied, Griet Van Imschoot, Elien Van Wonterghem, Lien Van Hoecke, Charysse Vandendriessche, Roosmarijn E. Vandenbroucke   +8 more
doaj   +1 more source

Adipocytes signal to recruit specific mRNAs from surrounding cells to restore expression deficits

Nature Communications
Extracellular vesicles (EVs) are nano-sized, membrane-delimited, particles released by cells that carry signaling macromolecules. A major pathway of EV production is potentiated by neutral sphingomyelinase 2 (SMPD3/nSMAse2), an enzyme that generates ...
Clair Crewe, Christy M. Gliniak, Toshiharu Onodera, Shiuhwei Chen, Jan-Bernd Funcke, May-Yun Wang, Snigdha Tiash, Yun-Ling Pai, Marjori Russo, Saket Awadhesbhai Patel, Ze Yu, Yi-Cian Zheng, Alex Larkin, Chao Xing, Laurent Gautron, Chun-Kan Chen, Chen Liu, Philipp E. Scherer   +17 more
doaj   +1 more source

Hypoxia and TNF‐alpha modulate extracellular vesicle release from human induced pluripotent stem cell‐derived cardiomyocytes

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication in the heart under homeostatic and pathological conditions, such as myocardial infarction (MI). However, the basic mechanisms driving cardiomyocyte‐derived EV
Margarida Viola, Maarten P. Bebelman, Renee G. C. Maas, Willemijn S. deVoogt, Frederik J. Verweij, Cor S. Seinen, Saskia C. A. deJager, Pieter Vader, Dirk Michiel Pegtel, Joost Petrus Gerardus Sluijter   +9 more
doaj   +1 more source

Astrocyte-derived extracellular vesicular NFIA mediates obesity-associated cognitive impairment

Journal of Neuroinflammation
Background The escalating global prevalence of cognitive decline associated with obesity represents a significant public health challenge. Emerging evidence implicates astrocyte-derived extracellular vesicles (ADEVs) as key mediators in the pathogenesis ...
Lining Wu, Liyun Deng, Xiaolin Xu, Haiqing Chang, Changliang Liu, Jiahui Wu, Changteng Zhang, Ruiqun Wang, Rui Gao, Hai Chen, Shixin Ye-Lehmann, Zhi Zhang, Tao Zhu, Chan Chen   +13 more
doaj   +1 more source

Genistein alleviates rheumatoid arthritis by inhibiting fibroblast-like synovial exosome secretion regulated by the Rab27/nSMase2/Mfge8 pathway

Food & Function
The therapeutic potential of genistein (GEN) in rheumatoid arthritis (RA), particularly with regard to its role in exosome secretion and the inflammatory microenvironment through the Rab27/Mfge8/nSMase2 pathway.
JiaJia Liu, Jinyang Shi, Sijia Niu, Ziyan Liu, XinHua Cui, Yuli Song, Xudong Tang, Junwen Fan, Hongyue Xu, Wanlu Yu, Mingmei Zhu, Baochun Lu, Ning Liao, Danping Peng, Yang Wang, Lu Yu   +15 more
openaire   +2 more sources

Correction to: Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model

Molecular Brain, 2021
Chunni Zhu, Tina Bilousova, Samantha Focht, Michael Jun, Chris Jean Elias, Mikhail Melnik, Sujyoti Chandra, Jesus Campagna, Whitaker Cohn, Asa Hatami, Patricia Spilman, Karen Hoppens Gylys, Varghese John   +12 more
doaj   +1 more source

Proinflammatory Stress Activates Neutral Sphingomyelinase 2-Based Generation of a Ceramide-Enriched β-Cell EV Subpopulation. [PDF]

Diabetes
Xu J, Amalaraj I, De Oliveira A, Harris-Kawano A, Enriquez JR, Mirmira RG, Eder JG, Burnet MC, Díaz Ludovico I, Flores JE, Nakayasu ES, Sims EK.   +11 more
europepmc   +1 more source