Results 61 to 70 of about 1,883 (170)
Glucocorticoids regulate small extracellular vesicle release via activation of nSMase2
Journal of Cell ScienceABSTRACT Glucocorticoid (GC) steroid hormones mediate the stress response, which requires dynamic communication between brain regions to enable an organism to react to and overcome perceived stressors. While many effects of GCs on the brain have been well-studied, little is known about whether and how GCs regulate brain cell–cell ...
Mia Burke, Clarissa Waites
openaire +3 more sources
Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.Chronic stress‐induced BD‐sEVs act as central‐to‐peripheral mediators, conveying stress signals to colorectal tumours and driving Treg differentiation via NOXA/HSP60‐triggered mtDNA release and cGAS‒STING activation, which suppresses antitumour immunity and correlates with anxiety and prognosis.
Huanhe Ni +11 more
wiley +1 more source
中性鞘磷脂酶2/神经酰胺调节高磷高钙诱导的血管平滑肌细胞成骨样分化和钙化
Zhongshan Daxue xuebao. Yixue kexue ban, 2018 ： 【目的】阐明nSMase2是否调控高磷高钙诱导的血管平滑肌细胞钙化。【方法】采用人血管平滑肌细 胞钙化体外模型，用高磷高钙诱导血管平滑肌细胞钙化。分别用鞘磷脂酶抑制剂GW4869和siRNA干扰敲低 nSMase2 处理血管平滑肌细胞，检测骨相关蛋白 BMP2、Runx2、Osterix 的表达和细胞钙化程度。【结果】在细胞 钙化过程中 nSMase2 的表达水平和神经酰胺的含量增高 ...
梁青春, 陈燕亭, 陆立鹤
doaj
, 2019 Recently, extracellular vesicles (EVs), such as exosomes, have been proposed to play an influential role in the cell-to-cell spread of neurodegenerative diseases, including the intercellular transmission of α-synuclein (α-syn). However, the regulation of
Livia Civitelli (153987) +6 more
core +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.ABSTRACT Background Skeletal muscle dysfunction (SMD) is a common extrapulmonary complication of chronic obstructive pulmonary disease (COPD). Histone deacetylase 2 (HDAC2) is closely involved in the suppression of inflammatory transcription and is progressively reduced during COPD progression.
Chao Li +4 more
wiley +1 more source
, 2019 Recently, extracellular vesicles (EVs), such as exosomes, have been proposed to play an influential role in the cell-to-cell spread of neurodegenerative diseases, including the intercellular transmission of α-synuclein (α-syn). However, the regulation of
Livia Civitelli (153987) +6 more
core +1 more source
A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside
Interdisciplinary Medicine, Volume 4, Issue 4, July 2026.This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione +2 more
wiley +1 more source
Neutral Sphingomyelinase 2 Inhibition Limits Hepatic Steatosis and Inflammation
CellsNon-alcoholic fatty liver disease (NAFLD) is manifested by hepatic steatosis, insulin resistance, hepatocyte death, and systemic inflammation. Obesity induces steatosis and chronic inflammation in the liver.
Fatema Al-Rashed +15 more
doaj +1 more source
Souris fragilitas ossium et mutation de la sphingomyélinase neutre de type 2 : implication dans l'apoptose et l'ostéochondrogenèse [PDF]
, 2011 Les sphingolipides sont des lipides complexes, qui rentrent dans la composition des membranes, mais sont également des agents de signalisation majeurs, impliqués dans de nombreuses réponses et régulations cellulaires, et dans la physiopathologie de ...
Devillard, Raphaël
core
, 2019 Recently, extracellular vesicles (EVs), such as exosomes, have been proposed to play an influential role in the cell-to-cell spread of neurodegenerative diseases, including the intercellular transmission of α-synuclein (α-syn). However, the regulation of
Livia Civitelli (153987) +6 more
core +1 more source