Results 81 to 90 of about 1,883 (170)

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Image_3_Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia.TIF

, 2019
Recently, extracellular vesicles (EVs), such as exosomes, have been proposed to play an influential role in the cell-to-cell spread of neurodegenerative diseases, including the intercellular transmission of α-synuclein (α-syn). However, the regulation of
Livia Civitelli (153987), Joakim Bergström (341007), Maitrayee Sardar Sinha (7320671), Christopher Sackmann (3605624), Anna Ansell-Schultz (7320674), Martin Hallbeck (3605621), Valerie Sackmann (7320668)   +6 more
core   +1 more source

Transcriptomics analysis reveals potential regulatory role of nSMase2 (Smpd3) in nervous system development and function of middle-aged mouse brains [PDF]

Neutral sphingomyelinase-2 (nSMase2), gene name sphingomyelin phosphodiesterase-3 (Smpd3), is a key regulatory enzyme responsible for generating the sphingolipid cer- amide. The function of nSMase2 in the brain is still controversial.
Zhu, Zhihui, McClintock, Timothy S., Bieberich, Erhard   +2 more
core   +1 more source

Astragaloside IV inhibits colorectal cancer metastasis by reducing extracellular vesicles release and suppressing M2-type TAMs activation

Heliyon
Ethnopharmacological relevance: Tumour-derived extracellular vesicles (TEVs) have been confirmed to facilitate colorectal cancer (CRC) metastasis by remodelling the tumour microenvironment (TME).
Jing Zhou, Ling Li, Yunzhou Pu, Haoze Li, Xinnan Wu, Ziyuan Wang, Jian Sun, Qing Song, Lihong Zhou, Xinwen Ma, Liu Yang, Qing Ji   +11 more
doaj   +1 more source

nSMase2 lentiviral integration does not change CDC survival, proliferation or gene expression.

, 2016
Nontransduced CDCs and nSMase2 shRNAi lentiviral infected CDCs show no significant difference in (A) survival assessed with calcien staining, (B) proliferation assessed with BrDU+ pulse or (C) surface marker expression (CD90, CD105 and CD45 plotted in ...
Jennifer K. Lang (344441), Hashmat Ashraf (3328575), Rebeccah F. Young (450291), John M. Canty Jr. (3328572)   +3 more
core   +1 more source

Effects of FKGK18 on ER Stress-Induced NSMase2 Expression in INS-1 OE Cells.

, 2013
INS-1 OE cells were treated with vehicle only or with thapsigargin (1 µM) for 8 or 24 h in the presence of FKGK18 (0.10, 1.0, or 10 µM). Total RNA was then prepared and cDNA generated and used to determine NSMase2 mRNA.
Tomader Ali (448333), George Kokotos (448334), William Hancock (448336), Sasanka Ramanadham (448337), Victoria Magrioti (448335), Robert N. Bone (323675), James A. Mobley (365303)   +6 more
core   +1 more source

Role and regulation of neutral sphingomyelinase-2 in response to DNA damage [PDF]

, 2015
Neutral sphingomylinase-2 (nSMase2) is a ceramide-generating enzyme that has been implicated in growth arrest, apoptosis and exosome secretion. In this thesis, we show that doxorubicin induces a dose-dependent induction of nSMase2 mRNA and protein levels
Shamseddine, Achraf
core   +1 more source

Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way

, 2017
Hypoxia treatment enhances paracrine effect of mesenchymal stem cells (MSCs). The aim of this study was to investigate whether exosomes from hypoxia-treated MSCs (Exo H ) are superior to those from normoxia-treated MSCs (Exo N ) for myocardial repair ...
Zhu, Jinyun, Lu, Kai, Zhang, Ning, Lin, Yinuo, Hu, Xinyang, Xiang, Pingping, Ma, Qunchao, Jian Shen, Yun Zhao, Zhu, Wei, Yinuo Lin, Yaoliang Tang, Jian’an Wang, Webster, Keith A, Jinghai Chen, Hong Yu, Ning Zhang, Yu, Hong, Chen, Jinghai, Keith A. Webster, Zhao, Yun, Xinyang Hu, Tang, Yaoliang, Pingping Xiang, Wei Zhu, Jinyun Zhu, Kai Lu, Shen, Jian, Qunchao Ma, Wang, Jian'an   +29 more
core   +1 more source

Challenging the conventional wisdom: Re‐evaluating Smpd3's role in extracellular vesicle biogenesis

Journal of Extracellular Biology
Extracellular vesicles (EVs) are pivotal in intercellular communication, impacting diverse physiological and pathological processes. Current in vitro EV biogenesis studies often utilize pharmacological inhibitors, inducing off‐target effects and ...
Marlies Burgelman, Pieter Dujardin, Anthony Willems, Tino Hochepied, Griet Van Imschoot, Elien Van Wonterghem, Lien Van Hoecke, Charysse Vandendriessche, Roosmarijn E. Vandenbroucke   +8 more
doaj   +1 more source

Adipocytes signal to recruit specific mRNAs from surrounding cells to restore expression deficits

Nature Communications
Extracellular vesicles (EVs) are nano-sized, membrane-delimited, particles released by cells that carry signaling macromolecules. A major pathway of EV production is potentiated by neutral sphingomyelinase 2 (SMPD3/nSMAse2), an enzyme that generates ...
Clair Crewe, Christy M. Gliniak, Toshiharu Onodera, Shiuhwei Chen, Jan-Bernd Funcke, May-Yun Wang, Snigdha Tiash, Yun-Ling Pai, Marjori Russo, Saket Awadhesbhai Patel, Ze Yu, Yi-Cian Zheng, Alex Larkin, Chao Xing, Laurent Gautron, Chun-Kan Chen, Chen Liu, Philipp E. Scherer   +17 more
doaj   +1 more source