Results 91 to 100 of about 1,883 (170)

Hypoxia and TNF‐alpha modulate extracellular vesicle release from human induced pluripotent stem cell‐derived cardiomyocytes

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication in the heart under homeostatic and pathological conditions, such as myocardial infarction (MI). However, the basic mechanisms driving cardiomyocyte‐derived EV
Margarida Viola, Maarten P. Bebelman, Renee G. C. Maas, Willemijn S. deVoogt, Frederik J. Verweij, Cor S. Seinen, Saskia C. A. deJager, Pieter Vader, Dirk Michiel Pegtel, Joost Petrus Gerardus Sluijter   +9 more
doaj   +1 more source

Microglial‐targeted nSMase2 inhibitor fails to reduce tau spread in the animal model of Alzheimer’s disease [PDF]

Alzheimers Dement
AbstractBackgroundCognitive decline associated with Alzheimer’s disease (AD) correlates with hyperphosphorylated tau (pTau) propagating between neurons along networks connected by synapses. It has been hypothesized this transcellular transmission occurs partially by extracellular vesicles (EVs).
Huang M, Tallon C, Zhu X, Huizar K, Piccirillo S, Thomas A, Tenora L, Liyanage W, Roda F, Gualerzi A, Kannan R, Bedoni M, Rais R, Slusher B.   +13 more
europepmc   +2 more sources

Overexpression of nSMase2 in 4T1 and E0771 Breast Cancer Cells Confers Varying Oncogenic Properties

, 2019
Cancer remains one of the deadliest diseases in the United States. One of the most prevalent types of cancer in women is breast cancer, second only to skin cancer.
Miranda, Ian
core  

Sending the Signal to Bone: How Tumor-Derived EVs Orchestrate Pre-Metastatic Niche Formation and Skeletal Colonization

Biomedicines
Bone is a preferred site for disseminated tumor cells, yet the molecular mechanisms that prepare the skeletal microenvironment for metastatic colonization are only beginning to be understood. At the heart of this process are extracellular vesicles (EVs),
Alhomam Dabaliz, Hagar Mahmoud, Raffi AlMutawa, Khalid S. Mohammad   +3 more
doaj   +1 more source

A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1.

, 2013
International audienceStress-inducing agents, including oxidative stress, generate the sphingolipid mediators ceramide (Cer) and sphingosine-1-phosphate (S1P) that are involved in stress-induced cellular responses.
Hannun, Yusuf,, Cinq-Frais, Christel, Coatrieux, Christelle, Grazide, Marie-Hélène, Hannun, Yusuf A, Augé, Nathalie, Salvayre, Robert, Nègre-Salvayre, Anne, Hannun, Yusuf, A.   +8 more
core   +1 more source

Genistein alleviates rheumatoid arthritis by inhibiting fibroblast-like synovial exosome secretion regulated by the Rab27/nSMase2/Mfge8 pathway

Food & Function
The therapeutic potential of genistein (GEN) in rheumatoid arthritis (RA), particularly with regard to its role in exosome secretion and the inflammatory microenvironment through the Rab27/Mfge8/nSMase2 pathway.
JiaJia Liu, Jinyang Shi, Sijia Niu, Ziyan Liu, XinHua Cui, Yuli Song, Xudong Tang, Junwen Fan, Hongyue Xu, Wanlu Yu, Mingmei Zhu, Baochun Lu, Ning Liao, Danping Peng, Yang Wang, Lu Yu   +15 more
openaire   +2 more sources

Neutral sphingomyelinase 2 heightens anti-melanoma immune response and synergizes with immune checkpoint inhibitors.

, 2019
International audienceAs part of a network of enzymes modulating the generation and degradation of sphingolipids, neutral sphingomyelinase 2 (nSMase2) catalyses the hydrolysis of the plasma membrane sphingomyelin into ceramide.
Montfort, Anne, Bertrand, Florie, Rochotte, Julia, Andrieu-Abadie, Nathalie, Levade, Thierry, Colacios, Céline, Ségui, Bruno   +6 more
core   +2 more sources

Astrocyte-derived extracellular vesicular NFIA mediates obesity-associated cognitive impairment

Journal of Neuroinflammation
Background The escalating global prevalence of cognitive decline associated with obesity represents a significant public health challenge. Emerging evidence implicates astrocyte-derived extracellular vesicles (ADEVs) as key mediators in the pathogenesis ...
Lining Wu, Liyun Deng, Xiaolin Xu, Haiqing Chang, Changliang Liu, Jiahui Wu, Changteng Zhang, Ruiqun Wang, Rui Gao, Hai Chen, Shixin Ye-Lehmann, Zhi Zhang, Tao Zhu, Chan Chen   +13 more
doaj   +1 more source

Correction to: Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model

Molecular Brain, 2021
Chunni Zhu, Tina Bilousova, Samantha Focht, Michael Jun, Chris Jean Elias, Mikhail Melnik, Sujyoti Chandra, Jesus Campagna, Whitaker Cohn, Asa Hatami, Patricia Spilman, Karen Hoppens Gylys, Varghese John   +12 more
doaj   +1 more source

Exosomes in cancer drug resistance: dual roles in therapy failure and emerging precision therapeutics. [PDF]

Cancer Cell Int
Tegegne BA, Belew H, Teffera ZH, Belayneh M, Abebaw D, Fikrie M, Jemal M, Baylie T, Tadesse F, Wondm SA, Zeleke TK, Belay WY.   +11 more
europepmc   +1 more source