Results 101 to 110 of about 1,596 (140)

An integrative approach to studying sphingolipid metabolism reveals p53 as a master regulator of the pathway. [PDF]

J Lipid Res
Ghandour B, Amin S, Medatwal N, Lee AH, Yu GQ, Resnick AE, Chiappone SB, Clarke CJ, Canals D, Hannun YA, Luberto C.   +10 more
europepmc   +1 more source

A review of recent advances in exosome-mediated drug delivery for regenerative therapy and immunomodulation. [PDF]

Biomed Eng Online
Azhar MA, Alshehri E, Assiri AM, Broering DC, Yaqinuddin A, Mir TA.   +5 more
europepmc   +1 more source

Glycolytic Enzyme HK2 Phosphorylates nSMase1 to Promote Astrocytic Exosomes Biogenesis Contributing to Acute Ischemic Stroke Injury. [PDF]

Adv Sci (Weinh)
Chen C, Zhou Y, Sheng L, Mai F, Ding Y, Hong S, Wu J, Pi J, Yan G, Huang Y, Duan J, Hua X, Yin W.   +12 more
europepmc   +1 more source

"Zombie virus" like pyroptosis: Extracellular vesicles spread pyroptosis by transferring functional N-GSDMD pore. [PDF]

J Transl Int Med
Zhang Y, Jin S, Tian Y, Qi J.
europepmc   +1 more source

HSP70 is a chaperone for IL-33 activity in chronic airway disease. [PDF]

JCI Insight
Osorio OA, Raphael HE, Kluender CE, Hassan GF, Cohen LS, Steinberg DF, Katz-Kiriakos E, Payne MD, Luo EM, Hicks JL, Byers DE, Alexander-Brett J.   +11 more
europepmc   +1 more source

Neutral sphingomyelinases and nSMase2: Bridging the gaps

Biochimica Et Biophysica Acta - Biomembranes, 2006
There is strong evidence indicating a role for ceramide as a second messenger in processes such as apoptosis, cell growth and differentiation, and cellular responses to stress. Ceramide formation from the hydrolysis of sphingomyelin is considered to be a major pathway of stress-induced ceramide production with magnesium-dependent neutral ...
Christopher Clarke, Yusuf Hannun
exaly   +3 more sources

Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2 [PDF]

Biochemical and Biophysical Research Communications, 2018
Targeting of molecular pathways involved in the cell-to-cell propagation of pathological tau species is a novel approach for development of disease-modifying therapies that could block tau pathology and attenuate cognitive decline in patients with Alzheimer's disease and other tauopathies. We discovered cambinol through a screening effort and show that
Varghese John, Emily Miyoshi, Mohammad Parvez Alam   +2 more
exaly   +5 more sources

Neutral Sphingomyelinase 2 (nSMase2) Is a Phosphoprotein Regulated by Calcineurin (PP2B) [PDF]

Journal of Biological Chemistry, 2010
We previously reported that exposure of human airway epithelial cells to oxidative stress increased ceramide generation via specific activation of neutral sphingomyelinase2 (nSMase2). Here we show that nSMase2 is a phosphoprotein exclusively phosphorylated at serine residues.
Anne Knowlton, Simone Filosto, Tzipora Goldkorn   +2 more
exaly   +3 more sources