Results 121 to 130 of about 1,596 (140)

nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer

ABSTRACT The pleiotropic roles of nSMase2-generated ceramide include regulation of intracellular ceramide signaling and exosome biogenesis. We investigated the effects of eliminating nSMase2 on early and advanced PDA, including its influence on the microenvironment. Employing the KPC mouse model of pancreatic cancer, we demonstrate that
Audrey M. Hendley, Sudipta Ashe, Atsushi Urano, Martin Ng, Tuan Anh Phu, Xianlu L. Peng, Changfei Luan, Anna-Marie Finger, Gun Ho Jang, Natanya R. Kerper, David I. Berrios, David Jin, Jonghyun Lee, Irene R. Riahi, Oghenekevwe M. Gbenedio, Christina Chung, Jeroen P. Roose, Jen Jen Yeh, Steven Gallinger, Andrew V. Biankin, Grainne M. O’Kane, Vasilis Ntranos, David K. Chang, David W. Dawson, Grace E. Kim, Valerie M. Weaver, Robert L. Raffai, Matthias Hebrok   +27 more
openaire   +2 more sources

Abstract A046: nSMase2-generated ceramide promotes PDA aggression through exosome reprogramming of the stroma

Cancer Research
Abstract The pleiotropic roles of nSMase2-generated ceramide include regulation of intracellular ceramide signaling and exosome biogenesis. Packaging of specific cellular constituents, such as prion protein and specific miRNAs involved in cancer progression, into exosomes are dependent on nSMase2.
Audrey M. Hendley, Atsushi Urano, Xianlu L. Peng, Sudipta Ashe, Tuan A. Phu, Martin Ng, Natanya R. Kerper, David I. Berrios, Jonghyun Lee, David Jin, Gun H. Jang, Oghenekevwe M. Gbenedio, Jeroen P. Roose, Jen J. Yeh, Steven Gallinger, Andrew V. Biankin, Vasilis Ntranos, David K. Chang, David W. Dawson, Grace E. Kim, Valerie M. Weaver, Robert L. Raffai, Matthias Hebrok   +22 more
openaire   +1 more source

Role of Acorus calamus extract in reducing exosome secretion by targeting Rab27a and nSMase2: a therapeutic approach for breast cancer

Molecular Biology Reports
Exosomes are extracellular vesicles released by cells that mediate intercellular communication and actively participate in cancer progression, metastasis, and regulation of immune response within the tumour microenvironment. Inhibiting exosome release from cancer cells could be employed as a therapeutic against cancer.In the present study, we have ...
Sunny, Gupta, Shipra, Gupta, Manju, Singh, Ashok Kumar, Patel   +3 more
exaly   +3 more sources

1576-P: Neutral Sphingomyelinase 2 (nSMase2) Regulates Insulin Synthesis, Secretion, and Glucose Sensing

Diabetes
Introduction and Objective: Neutral sphingomyelinase 2 (nSMase2) is a crucial enzyme involved in several important cellular processes, including exosome formation, ceramide production, cellular stress responses, and inflammatory signaling responses. However, impacts on beta cell health are unknown. Methods: INS-1 823/13 nSMase2 knockdown
JERRY XU, EMILY K. SIMS
openaire   +1 more source

Abstract A066: nSMase2-mediated exosome secretion shapes the tumor microenvironment to immunologically support pancreatic cancer

Cancer Research
Abstract The pleiotropic roles of nSMase2-generated ceramide include regulation of intracellular ceramide signaling and exosome biogenesis. We investigated the effects of eliminating nSMase2 on early and advanced PDA, including its influence on the microenvironment.
Audrey M Hendley, Sudipta Ashe, Atsushi Urano, Martin Ng, Tuan A Phu, Xianlu Laura Peng, Changfei Luan, Anna-Marie Finger, Gun Ho Jang, Natanya R Kerper, David I Berrios, David Jin, Jonghyun Lee, Irene R Riahi, Oghenekevwe M Gbenedio, Christina Chung, Jeroen P Roose, Jen Jen Yeh, Steven Gallinger, Andrew V Biankin, Grainne M O’Kane, Vasilis Ntranos, David K Chang, David W Dawson, Grace E Kim, Valerie M Weaver, Robert L Raffai, Matthias Hebrok   +27 more
openaire   +1 more source

nSMase2 in Lung Injury under Cigarette Smoke.

C28. EXTRACELLULAR STRESS REGULATORY MECHANISMS AND DISEASE, 2009
T Goldkorn, K Pinkerton, E Khan
openaire   +1 more source

Allosteric Inhibition of Neutral Sphingomyelinase 2 (nSMase2) by DPTIP: From Antiflaviviral Activity to Deciphering Its Binding Site through In Silico Studies and Experimental Validation

International Journal of Molecular Sciences, 2022
MIGUEL A Martín-Acebes, Flavia Caridi, Juan-Carlos Saiz   +2 more
exaly  

The regulatory mechanism of NSMase2 gene expression by ATRA in MCF7 cells

Chemistry and Physics of Lipids, 2010
H. Ito, M. Murakami, K. Hagiwara, N. Sasaki, M. Kobayashi, A. Hoshikawa, A. Takagi, T. Kojima, Y. Banno, K. Tamiya-Koizumi, M. Nakamura, Y. Nozawa, T. Murate   +12 more
openaire   +1 more source

Therapeutic Application of Extracellular Vesicles-Capsulated Adeno-Associated Virus Vector via nSMase2/Smpd3, Satellite, and Immune Cells in Duchenne Muscular Dystrophy

International Journal of Molecular Sciences, 2022
Takashi Okada, Kazuo Hashido, Yasunari Matsuzaka   +2 more
exaly  

Neutral Sphingomyelinase 2 (nSMase2) And Lung Injury: A Phosphorylation-Based Mechanism Controls NSMase2 Activity And Protein Stability In Lung Epithelial Cells Exposed To Oxidative Stress

C69. CELLULAR SIGNALING OF OXIDATIVE STRESS, 2012
Simone Filosto, Samuel Chung, Tzipora Goldkorn   +2 more
openaire   +1 more source