Results 131 to 140 of about 1,883 (170)

Research Progress of Exosome-Derived microRNA in Alcohol Use Disorders: A Critical Review. [PDF]

Addict Biol
Zhang B, Xie TT, Ma Q, Jiang YP, Wang YM.   +4 more
europepmc   +1 more source

Behind the membranous curtain-lipid dynamics and functions in coronaviral replication. [PDF]

J Virol
Salisch F, Müller-Ruttloff C.
europepmc   +1 more source

Mechanisms of tumor-derived extracellular vesicle-mediated immunometabolic reprogramming and immunotherapeutic resistance. [PDF]

Mol Cancer
Zeng H, Zhang R, Zhu X, Shen S, Zou H.
europepmc   +1 more source

Mechanistic interplay between extracellular vesicles and neutrophil extracellular traps: unveiling the "sterile inflammation" cascade in obesity-induced diabetes progression. [PDF]

Front Immunol
Gao H, Luo XX, Fu Y, Chen Y, Ning SY, Han X, Wang L, Wang QF.   +7 more
europepmc   +1 more source

Bubble Ticket Trip: Exploring the Mechanism of miRNA Sorting into Exosomes and Maintaining the Stability of Tumor Microenvironment. [PDF]

Int J Nanomedicine
Wang L, Liu H, Chen G, Wu Q, Xu S, Zhou Q, Zhao Y, Wang Q, Yan T, Cheng X.   +9 more
europepmc   +1 more source

Neutral sphingomyelinases and nSMase2: Bridging the gaps [PDF]

Biochimica Et Biophysica Acta - Biomembranes, 2006
There is strong evidence indicating a role for ceramide as a second messenger in processes such as apoptosis, cell growth and differentiation, and cellular responses to stress. Ceramide formation from the hydrolysis of sphingomyelin is considered to be a
Christopher J Clarke, Yusuf A. Hannun
exaly   +4 more sources

Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2 [PDF]

Biochemical and Biophysical Research Communications, 2018
Targeting of molecular pathways involved in the cell-to-cell propagation of pathological tau species is a novel approach for development of disease-modifying therapies that could block tau pathology and attenuate cognitive decline in patients with ...
Varghese John, Emily Miyoshi, Mohammad Parvez Alam   +2 more
exaly   +7 more sources

Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance Ceramide is a bioactive lipid involved in numerous cellular functions and disease states that are critically dependent on its site of generation.
Lina M Obeid, Miguel Garcia-Diaz, Yusuf A. Hannun   +2 more
exaly   +4 more sources

Evidence for coordination of lysosomal (ASMase) and plasma membrane (NSMase2) forms of sphingomyelinase from mutant mice [PDF]

FEBS Letters, 2012
NSMase2 is associated to the plasma membrane, whereas ASMase is predominantly lysosomal; both hydrolyze sphingomyelin (SM) to ceramide and phosphocholine.
Glyn Dawson
exaly   +5 more sources