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Cancer Research
Abstract The pleiotropic roles of nSMase2-generated ceramide include regulation of intracellular ceramide signaling and exosome biogenesis. Packaging of specific cellular constituents, such as prion protein and specific miRNAs involved in cancer progression, into exosomes are dependent on nSMase2.
Audrey M. Hendley +22 more
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Abstract The pleiotropic roles of nSMase2-generated ceramide include regulation of intracellular ceramide signaling and exosome biogenesis. Packaging of specific cellular constituents, such as prion protein and specific miRNAs involved in cancer progression, into exosomes are dependent on nSMase2.
Audrey M. Hendley +22 more
openaire +1 more source
Molecular Biology Reports
Exosomes are extracellular vesicles released by cells that mediate intercellular communication and actively participate in cancer progression, metastasis, and regulation of immune response within the tumour microenvironment. Inhibiting exosome release from cancer cells could be employed as a therapeutic against cancer.In the present study, we have ...
Sunny, Gupta +3 more
exaly +3 more sources
Exosomes are extracellular vesicles released by cells that mediate intercellular communication and actively participate in cancer progression, metastasis, and regulation of immune response within the tumour microenvironment. Inhibiting exosome release from cancer cells could be employed as a therapeutic against cancer.In the present study, we have ...
Sunny, Gupta +3 more
exaly +3 more sources
Diabetes
Introduction and Objective: Neutral sphingomyelinase 2 (nSMase2) is a crucial enzyme involved in several important cellular processes, including exosome formation, ceramide production, cellular stress responses, and inflammatory signaling responses. However, impacts on beta cell health are unknown. Methods: INS-1 823/13 nSMase2 knockdown
JERRY XU, EMILY K. SIMS
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Introduction and Objective: Neutral sphingomyelinase 2 (nSMase2) is a crucial enzyme involved in several important cellular processes, including exosome formation, ceramide production, cellular stress responses, and inflammatory signaling responses. However, impacts on beta cell health are unknown. Methods: INS-1 823/13 nSMase2 knockdown
JERRY XU, EMILY K. SIMS
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nSMase2 in Lung Injury under Cigarette Smoke.
C28. EXTRACELLULAR STRESS REGULATORY MECHANISMS AND DISEASE, 2009T Goldkorn, K Pinkerton, E Khan
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Cancer Research
Abstract The pleiotropic roles of nSMase2-generated ceramide include regulation of intracellular ceramide signaling and exosome biogenesis. We investigated the effects of eliminating nSMase2 on early and advanced PDA, including its influence on the microenvironment.
Audrey M Hendley +27 more
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Abstract The pleiotropic roles of nSMase2-generated ceramide include regulation of intracellular ceramide signaling and exosome biogenesis. We investigated the effects of eliminating nSMase2 on early and advanced PDA, including its influence on the microenvironment.
Audrey M Hendley +27 more
openaire +1 more source
The regulatory mechanism of NSMase2 gene expression by ATRA in MCF7 cells
Chemistry and Physics of Lipids, 2010H. Ito +12 more
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nSMASE2 INHIBITOR PRODRUGS WITH ENHANCED ORAL AND BRAIN EXPOSURES
2022SLUSHER BARBARA, PAL ARINDOM S
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Lack Of The Neutral Sphingomyelinase NSMASE2 Induces Lung Dysfunction Similar To Emphysema
D28. PATHOPHYSIOLOGY OF EMPHYSEMA, 2011Christiana Dimitropoulou +3 more
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SMALL MOLECULE NEUTRAL SPHINGOMYELINASE 2 (nSMase2) INHIBITORS
2020TSUKAMOTO TAKASHI +5 more
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