Results 141 to 150 of about 1,883 (170)
Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-α in MCF-7 cells [PDF]
Biochemical Journal, 2011 Activation of N-SMase (neutral sphingomyelinase) is an established part of the response of cytokines such as TNF (tumour necrosis factor)-α. However, it remains unclear which of the currently cloned N-SMase isoforms (nSMase1, nSMase2 and nSMase3) are ...
Christopher J Clarke, Yusuf A. Hannun
exaly +4 more sources
International Journal of Molecular Sciences, 2022 Flavivirus comprises globally emerging and re-emerging pathogens such as Zika virus (ZIKV), Dengue virus (DENV), and West Nile virus (WNV), among others.
Miguel A Martín-Acebes +2 more
exaly +2 more sources
Neutral Sphingomyelinase 2 (nSMase2) Is a Phosphoprotein Regulated by Calcineurin (PP2B)* [PDF]
Journal of Biological Chemistry, 2010 We previously reported that exposure of human airway epithelial cells to oxidative stress increased ceramide generation via specific activation of neutral sphingomyelinase2 (nSMase2). Here we show that nSMase2 is a phosphoprotein exclusively phosphorylated at serine residues.
Simone Filosto, Tzipora Goldkorn
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Drug Discovery Today, 2021
Extracellular vesicles (EVs) are indispensable mediators of intercellular communication, but they can also assume a nefarious role by ferrying pathological cargo that contributes to neurological, oncological, inflammatory, and infectious diseases. The canonical pathway for generating EVs involves the endosomal sorting complexes required for transport ...
Norman J Haughey +2 more
exaly +3 more sources
Extracellular vesicles (EVs) are indispensable mediators of intercellular communication, but they can also assume a nefarious role by ferrying pathological cargo that contributes to neurological, oncological, inflammatory, and infectious diseases. The canonical pathway for generating EVs involves the endosomal sorting complexes required for transport ...
Norman J Haughey +2 more
exaly +3 more sources
nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis [PDF]
Biochemical and Biophysical Research Communications, 2006 We have previously shown that accumulation of ceramide, triggered by hydrogen peroxide (H(2)O(2)), induces apoptosis of human airway epithelial (HAE) cells. Under oxidant exposure, a lung sphingomyelinase (SMase) is activated and displays continued ceramide generation and pro-apoptotic signaling, thus leading to the pathological apoptosis that causes ...
Tzipora Goldkorn
exaly +3 more sources
nSMase2 inhibition reduces tau propagation in Alzheimer’s Disease mouse models
Alzheimer's & Dementia, 2022AbstractBackgroundAlzheimer’s Disease (AD) is the most common form of dementia worldwide and is characterized by progressive neurodegeneration and cognitive decline, putatively driven by the accumulation Amyloid‐b and hyperphosphorylated Tau. Clinical trial successes focusing on reducing Amyloid‐b plaque levels in patient brains have been modest ...
Carolyn Tallon +16 more
openaire +1 more source
Abstract A59: A tumor supressor role for nSMase2 in triple negative breast cancer
Cancer Immunology Research, 2022Abstract PURPOSEIn this study, we assess a putative tumor suppressor role for neutral sphingomyelinase-2 (nSMase2) in triple negative breast cancer (TNBC) and determine if nSMase2 effects are through cell intrinsic or extrinsic mechanisms.
Andrew E Resnick +8 more
openaire +1 more source
Journal of Physiology and Biochemistry, 2022
Exosomes have a critical role in the intercellular communication and metastatic progression of hepatocellular carcinoma (HCC). Recently, our group showed that α2, 6-sialylation played an important role in the proliferation- and migration-promoting effects of cancer-derived exosomes. However, the molecular basis remains elusive.
Liping Wang +9 more
openaire +2 more sources
Exosomes have a critical role in the intercellular communication and metastatic progression of hepatocellular carcinoma (HCC). Recently, our group showed that α2, 6-sialylation played an important role in the proliferation- and migration-promoting effects of cancer-derived exosomes. However, the molecular basis remains elusive.
Liping Wang +9 more
openaire +2 more sources
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2012
Chronic exposure of blood vessels to cardiovascular risk factors such as free fatty acids, LDL-cholesterol, homocysteine and hyperglycemia can give rise to endothelial dysfunction, partially due to decreased synthesis and bioavailability of nitric oxide (NO). Many of these same risk factors have been shown to induce endoplasmic reticulum (ER) stress in
Ruchi, Chaube +6 more
openaire +2 more sources
Chronic exposure of blood vessels to cardiovascular risk factors such as free fatty acids, LDL-cholesterol, homocysteine and hyperglycemia can give rise to endothelial dysfunction, partially due to decreased synthesis and bioavailability of nitric oxide (NO). Many of these same risk factors have been shown to induce endoplasmic reticulum (ER) stress in
Ruchi, Chaube +6 more
openaire +2 more sources
ABSTRACT The pleiotropic roles of nSMase2-generated ceramide include regulation of intracellular ceramide signaling and exosome biogenesis. We investigated the effects of eliminating nSMase2 on early and advanced PDA, including its influence on the microenvironment. Employing the KPC mouse model of pancreatic cancer, we demonstrate that
Audrey M. Hendley +27 more
openaire +2 more sources
Audrey M. Hendley +27 more
openaire +2 more sources