Results 51 to 60 of about 1,881 (140)

Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels

Cell Reports, 2020
Summary: Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines.
Jian Shi, Adam J. Hyman, Dario De Vecchis, Jiehan Chong, Laeticia Lichtenstein, T. Simon Futers, Myriam Rouahi, Anne Negre Salvayre, Nathalie Auge, Antreas C. Kalli, David J. Beech   +10 more
doaj   +1 more source

Integrative Analysis of Blood Transcriptomics and Metabolomics Reveals Molecular Regulation of Backfat Thickness in Qinchuan Cattle

Animals, 2023
A crucial goal of reducing backfat thickness (BFT) is to indirectly improve feed conversion efficiency. This phenotype has been reported in certain papers; however, the molecular mechanism has yet to be fully revealed.
Hengwei Yu, Sayed Haidar Abbas Raza, Yueting Pan, Gong Cheng, Chugang Mei, Linsen Zan   +5 more
doaj   +1 more source

Gene expression of ceramide metabolism enzymes in fat depots of different localization in cardiovascular diseases

Российский кардиологический журнал, 2023
Aim. To assess gene expression of enzymes of the sphingomyelinase pathway of ceramide biosynthesis and degradation in fat depots of various localization in patients with cardiovascular diseases.Material and methods.
O. V. Gruzdeva, E. V. Belik, Yu. A. Dyleva, E. G. Uchasova, A. V. Ponasenko, A. G. Kutikhin, V. E. Markova, E. E. Gorbatovskaya, E. V. Fanaskova, S. V. Ivanov, A. N. Stasev, M. G. Zinets, T. A. Slesareva, O. L. Barbarash   +13 more
doaj   +1 more source

Potential biomarkers of abnormal osseointegration of implants in type II diabetes mellitus

BMC Oral Health, 2021
Background Type II diabetes mellitus (T2DM) is an important risk factor for osseointegration of implants. The aim of this study was to explore key genes of T2DM affecting bone metabolism through bioinformatic analysis of published RNA sequencing data ...
Lingxiao Wang, Zhenhua Gao, Changying Liu, Jun Li   +3 more
doaj   +1 more source

Involvement of ceramide biosynthesis in increased extracellular vesicle release in Pkd1 knock out cells

Frontiers in Endocrinology, 2022
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is an inherited disorder characterized by the development of renal cysts, which frequently leads to renal failure.
Valentina Carotti, Jenny van der Wijst, Eric H. J. Verschuren, Luco Rutten, Nico Sommerdijk, Charlotte Kaffa, Vera Sommers, Juan P. Rigalli, Joost G. J. Hoenderop   +8 more
doaj   +1 more source

SMPD3-mediated extracellular vesicle biogenesis inhibits oligodendroglioma growth [PDF]

, 2020
Abstract Oligodendrogliomas are lower-grade, slow-growing gliomas that are ultimately fatal. Although driver mutations are known, the mechanisms underlying their signature slow growth rates are poorly understood. We found evidence for intra-tumoral interactions between neoplastic and non-neoplastic cells in oligodendroglioma tissues. To further
Anjali Balakrishnan, Lata Adnani, Vorapin Chinchalongporn, Lakshmy Vasan, Oleksandr Prokopchuk, Myra Chen, Ahmed El-Sehemy, Thomas Olender, Yacine Touahri, Shiekh Tanveer Ahmad, Rehnuma Islam, Sajeevan Sujanthan, Dawn Zinyk, Lacrimioara Comanita, Boris Kan, Taylor Fleming, Hon Leong, Cindi Morshead, Marjorie Brand, Valerie Wallace, Jennifer Chan, Carol Schuurmans   +21 more
openaire   +1 more source

Involvement of Cryptosporidium parvum Cdg7_FLc_1000 RNA in the Attenuation of Intestinal Epithelial Cell Migration via Trans-Suppression of Host Cell SMPD3 [PDF]

The Journal of Infectious Diseases, 2017
Intestinal infection by Cryptosporidium parvum causes inhibition of epithelial turnover, but underlying mechanisms are unclear. Previous studies demonstrate that a panel of parasite RNA transcripts of low protein-coding potential are delivered into infected epithelial cells.
Z. Ming, A. Gong, Yang Wang, Xin‐Tian Zhang, Min Li, N. W. Mathy, J. Strauss-Soukup, Xian-Ming Chen   +7 more
semanticscholar   +3 more sources

Abstract 5790 Regulation and functions of neutral sphingomyelinase 2 (smpd3) during metabolic disfunction-associated steatotic liver disease

Journal of Biological Chemistry
M. Nikolova-Karakashian, L. Robles, Salim S. El-Amouri, Kylie Morin, Erhard Bieberich, P. Sullivan, Yusuf A. Hannun, Ashley Snider   +7 more
semanticscholar   +2 more sources

SpPdp11 Administration in Diet Modified the Transcriptomic Response and Its Microbiota Associated in Mechanically Induced Wound Sparus aurata Skin

Animals, 2023
Skin lesions are a frequent fact associated with intensive conditions affecting farmed fish. Knowing that the use of probiotics can improve fish skin health, SpPdp11 dietary administration has demonstrated beneficial effects for farmed fish, so its ...
Isabel M. Cerezo, Olivia Pérez-Gómez, Rocio Bautista, Pedro Seoane, M. Ángeles Esteban, M. Carmen Balebona, Miguel A. Moriñigo, Silvana T. Tapia-Paniagua   +7 more
doaj   +1 more source

Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue

Lipids in Health and Disease, 2012
Background Inflammation and increased ceramide concentrations characterise adipose tissue of obese women with high liver fat content compared to equally obese women with normal liver fat content.
Kolak Maria, Gertow Joanna, Westerbacka Jukka, Summers Scott A, Liska Jan, Franco-Cereceda Anders, Orešič Matej, Yki-Järvinen Hannele, Eriksson Per, Fisher Rachel M   +9 more
doaj   +1 more source