Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration [PDF]
, 2010 Ceramide and its metabolic derivatives are important modulators of cellular apoptosis and proliferation. Dysregulation or imbalance of their metabolic pathways may promote the development of retinal degeneration. The aim of this study was to identify the
Sreekumar, Parameswaran G. +3 more
core +1 more source
The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 2, June 2026.Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao +4 more
wiley +1 more source
Transcriptomics analysis reveals potential regulatory role of nSMase2 (Smpd3) in nervous system development and function of middle-aged mouse brains [PDF]
Neutral sphingomyelinase-2 (nSMase2), gene name sphingomyelin phosphodiesterase-3 (Smpd3), is a key regulatory enzyme responsible for generating the sphingolipid cer- amide. The function of nSMase2 in the brain is still controversial.
Zhu, Zhihui +2 more
core +1 more source
Osteoblast-specific Krm2 overexpression and Lrp5 deficiency have different effects on fracture healing in mice. [PDF]
PLoS ONE, 2014 The canonical Wnt/β-catenin pathway plays a key role in the regulation of bone remodeling in mice and humans. Two transmembrane proteins that are involved in decreasing the activity of this pathway by binding to extracellular antagonists, such as ...
Astrid Liedert +9 more
doaj +1 more source
Journal of Extracellular Biology, Volume 5, Issue 4, April 2026.ABSTRACT Extracellular vesicle (EV) heterogeneity is well documented but poorly defined. This is especially important in cancer where EVs serve as carriers of unique oncogenic macromolecules that can be transferred to recipient cells or targeted for liquid biopsy diagnostics.
Elham Pishavar +8 more
wiley +1 more source
MAGNETIC PROPERTIES OF THE AuCu3-TYPE Sm-COMPOUNDS
, 1988 Resistivity, susceptibility, specific heat and magnetization measurements on single crystals SmPb3, SmPd3 and SmTl3 are performed. The phase transition of the antiferromagnet, SmPb3, is of first order at 5.1 K.
M. Kasaya, B. Liu, T. Kasuya
core +1 more source
Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane
Journal of Extracellular Vesicles, 2017 Extracellular vesicles (EVs) are membrane particles secreted from cells into all body fluids. Several EV populations exist differing in size and cellular origin.
Kerstin Menck +10 more
doaj +1 more source
Genome-Wide DNA Methylation Profiles of Phlegm-Dampness Constitution
Cellular Physiology and Biochemistry, 2018 Background/Aims: Metabolic diseases are leading health concerns in today’s global society. In traditional Chinese medicine (TCM), one body type studied is the phlegm-dampness constitution (PC), which predisposes individuals to complex metabolic disorders.
Haiqiang Yao +12 more
doaj +1 more source
Identification of ceRNA Regulatory Networks Driven by the lncRNA NEAT1 in Multiple Myeloma
Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.ABSTRACT The lncRNA NEAT1 is overexpressed in multiple myeloma (MM) plasma cells and plays a key role in MM pathogenesis. NEAT1 is involved in ceRNA network in several cancers; however, data in MM are virtually absent. This study identified a NEAT1‐driven ceRNA network involving 96 miRNAs and 40 target genes, selected as concurrently downregulated in ...
Domenica Ronchetti +14 more
wiley +1 more source
A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization
, 2011 A deletion mutation called fro (fragilitas ossium) in the murine Smpd3 (sphingomyelin phosphodiesterase 3) gene leads to a severe skeletal dysplasia. Smpd3 encodes a neutral sphingomyelinase (nSMase2), which cleaves sphingomyelin to generate bioactive ...
Marc D. McKee +7 more
core +1 more source