Results 71 to 80 of about 1,842 (145)

Neutral sphingomyelinase 2 heightens anti-melanoma immune responses and anti-PD-1 therapy efficacy.

, 2021
International audienceHow dysregulation of lipid metabolism affects the behavior of cancer cells is not completely understood. SMPD3, encoding neutral sphingomyelinase 2 (nSMase2), catalyzes the breakdown of sphingomyelin to produce the anti ...
Ségui, Bruno
core   +1 more source

Neutral Sphingomyelinase 2 Inhibition Limits Hepatic Steatosis and Inflammation

Cells
Non-alcoholic fatty liver disease (NAFLD) is manifested by hepatic steatosis, insulin resistance, hepatocyte death, and systemic inflammation. Obesity induces steatosis and chronic inflammation in the liver.
Fatema Al-Rashed, Hossein Arefanian, Ashraf Al Madhoun, Fatemah Bahman, Sardar Sindhu, Halemah AlSaeed, Texy Jacob, Reeby Thomas, Areej Al-Roub, Fawaz Alzaid, MD Zubbair Malik, Rasheeba Nizam, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Yusuf A. Hannun, Rasheed Ahmad   +15 more
doaj   +1 more source

Retrotransposon Expression Is Upregulated in Adulthood and Suppressed during Regeneration of the Limb in the Axolotl (Ambystoma mexicanum)

Advanced Biology, Volume 9, Issue 10, October 2025.
The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez, Nicolás Alcaraz, Karla Torres‐Arciga, José Antonio Ocampo‐Cervantes, Alejandra Cervera, Clementina Castro‐Hernández, Cynthia Gabriela Sámano‐Salazar, Ernesto Soto‐Reyes, Rodrigo González‐Barrios   +8 more
wiley   +1 more source

The regulation of Smpd3 expression and its role in skeletal tissues

, 2018
Sphingomyelin phosphodiesterase 3 (SMPD3), a lipid metabolizing enzyme present in the endoplasmic reticulum and plasma membranes of cells has important roles in the developing skeleton including the promotion of apoptosis of hypertrophic chondrocytes and
Manickam, Garthiga
core  

Demonstration of Choroid Plexus-Subventricular Zone Regulatory (CSR) Axis Mediated by Small Extracellular Vesicles: Toxicological, Molecular, and Neurobehavioral Characterizations

, 2023
The choroid plexus (CP) in brain ventricles secrete cerebrospinal fluid (CSF) that bathes the adjacent subventricular zone (SVZ); the latter is the largest neurogenic region in adult brain harboring neural stem/progenitor cells (NSPCs) and supplies ...
Liu, Luqing L
core   +1 more source

The expression of PHOSPHO1, nSMase2 and TNAP is coordinately regulated by continuous PTH exposure in mineralising osteoblast cultures [PDF]

, 2016
Sustained exposure to high levels of parathyroid hormone (PTH), as observed in hyperparathyroidism, are catabolic to bone. The increase in the RANKL/OPG ratio in response to continuous PTH, resulting in increased osteoclastogenesis is well established ...
Farquharson, C, Staines, KA; id_orcid, K. A. Staines, MacRae, V E, Houston, DA, MacRae, VE, D. A. Houston, MacRae, Victoria, Staines, K A, Farquharson, Colin; id_orcid, Houston, D A, K. Myers, V. E. MacRae, C. Farquharson, Staines, Katherine, Myers, K, Myers, Katherine, Houston, Dean   +17 more
core   +2 more sources

Precise Lipidomics Decipher Circulating Ceramide and Sphingomyelin Cycle Associated with the Progression of Rheumatoid Arthritis

, 2023
Rheumatoid arthritis (RA) is a long-term autoimmune condition that causes joint and surrounding tissue inflammation. Lipid mediators are involved in inflammation and deterioration of the joints.
Shuailong Chen (17291346), Tiangang Luan, Longshan Zhao (544964), Hemi Luan (513560), Shuailong Chen, Shijia Liu, Tiangang Luan (1517485), Shijia Liu (5370089), Longshan Zhao, Hemi Luan   +9 more
core   +1 more source

Proteogenomic network analysis reveals dysregulated mechanisms and potential mediators in Parkinson’s disease

Nature Communications
Parkinson’s disease is highly heterogeneous across disease symptoms, clinical manifestations and progression trajectories, hampering the identification of therapeutic targets.
Abolfazl Doostparast Torshizi, Dongnhu T. Truong, Liping Hou, Bart Smets, Christopher D. Whelan, Shuwei Li   +5 more
doaj   +1 more source

Generation of viable «fro/fro» mice and analyses of their mineralized tissue

, 2014
Sphingomyelin phosphodiesterase 3 (SMPD3), a plasma membrane-bound enzyme, cleaves sphingomyelin to generate ceramide and phosphorylcholine. These two bioactive lipid metabolites regulate many cellular activities.
Alebrahim, Sharifa
core  

Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α

, 2020
Obesity is associated with elevated levels of TNF-alpha and proinflammatory CD11c monocytes/macrophages. TNF-alpha mediated dysregulation in the plasticity of monocytes/macrophages is concomitant with pathogenesis of several inflammatory diseases ...
Obeid, Lina M, Ahmad, Zunair, Melhem, Motasem, Hannun, Yusuf A, Al-Rashed, Fatema, Ahmad, Rasheed, Thomas, Reeby, Snider, Ashley J, Al-Mulla, Fahd   +8 more
core   +1 more source