Results 61 to 70 of about 1,881 (140)

Single cell cortical bone transcriptomics define novel osteolineage gene sets altered in chronic kidney disease

Frontiers in Endocrinology, 2023
IntroductionDue to a lack of spatial-temporal resolution at the single cell level, the etiologies of the bone dysfunction caused by diseases such as normal aging, osteoporosis, and the metabolic bone disease associated with chronic kidney disease (CKD ...
Rafiou Agoro, Intawat Nookaew, Megan L. Noonan, Yamil G. Marambio, Sheng Liu, Wennan Chang, Wennan Chang, Hongyu Gao, Hongyu Gao, Lainey M. Hibbard, Corinne E. Metzger, Daniel Horan, William R. Thompson, Xiaoling Xuei, Yunlong Liu, Yunlong Liu, Chi Zhang, Chi Zhang, Alexander G. Robling, Lynda F. Bonewald, Lynda F. Bonewald, Jun Wan, Kenneth E. White, Kenneth E. White   +23 more
doaj   +1 more source

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1494-1502, June 2026.
Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz, Eric Farber‐Eger, Marwa Tantawy, Neyousha Shahisavandi, Timothy J. Garrett, Samuel M. Rubinstein, Michael G. Fradley, Mohammed E. Alomar, Danny DeAvila, Kenneth H Shain, R. Frank Cornell, Daniel Lenihan, Qing Lu, Quinn S Wells, Rachid C. Baz, Yan Gong   +15 more
wiley   +1 more source

Extracellular Vesicles in the Biology and Liquid Biopsy Diagnostics of Pediatric High‐Grade Glioma – Emerging Findings and Opportunities

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Liquid biopsy has emerged as an important diagnostic paradigm impacting care across multiple cancer indications. This is also an area of great interest in pediatric solid tumours, including those affecting the central nervous system (CNS). Of special concern are pediatric high‐grade gliomas (pHGGs) due to the associated diagnostic complexities,
Samia Jahouri, Laura Montermini, Nadim Tawil, Mahsa Jalali, Livia Garzia, Nada Jabado, Janusz Rak   +6 more
wiley   +1 more source

Role of SMPD3 during Bone Fracture Healing and Regulation of Its Expression

Molecular and Cellular Biology, 2018
Sphingomyelin phosphodiesterase 3 (SMPD3), a lipid-metabolizing enzyme present in bone and cartilage, has important roles in the developing skeleton. We previously showed that SMPD3 deficiency results in delayed extracellular matrix (ECM) mineralization ...
Garthiga Manickam, P. Moffatt, M. Murshed   +2 more
semanticscholar   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Identification of Potential Key Genes Associated With the Pathogenesis and Prognosis of Gastric Cancer Based on Integrated Bioinformatics Analysis

Frontiers in Genetics, 2018
Background and Objective: Despite striking advances in multimodality management, gastric cancer (GC) remains the third cause of cancer mortality globally and identifying novel diagnostic and prognostic biomarkers is urgently demanded.
Xinkui Liu, Jiarui Wu, Dan Zhang, Zhitong Bing, Zhitong Bing, Zhitong Bing, Jinhui Tian, Jinhui Tian, Mengwei Ni, Xiaomeng Zhang, Ziqi Meng, Shuyu Liu   +11 more
doaj   +1 more source

Glioblastoma Cells Expressing Oncogenic EGFR Release Multiple Extracellular Vesicle Subpopulations Positive or Negative for EGFR

Journal of Extracellular Biology, Volume 5, Issue 4, April 2026.
ABSTRACT Extracellular vesicle (EV) heterogeneity is well documented but poorly defined. This is especially important in cancer where EVs serve as carriers of unique oncogenic macromolecules that can be transferred to recipient cells or targeted for liquid biopsy diagnostics.
Elham Pishavar, Fereshteh Shojaei‐Ghahrizjani, Brian Meehan, Nadim Tawil, Cristiana Spinelli, Dongsic Choi, Fang Cheng Wong, Mahsa Jalali, Janusz Rak   +8 more
wiley   +1 more source

Identification of ceRNA Regulatory Networks Driven by the lncRNA NEAT1 in Multiple Myeloma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT The lncRNA NEAT1 is overexpressed in multiple myeloma (MM) plasma cells and plays a key role in MM pathogenesis. NEAT1 is involved in ceRNA network in several cancers; however, data in MM are virtually absent. This study identified a NEAT1‐driven ceRNA network involving 96 miRNAs and 40 target genes, selected as concurrently downregulated in ...
Domenica Ronchetti, Valentina Traini, Ilaria Silvestris, Giuseppina Fabbiano, Andrea Devecchi, Federica Torricelli, Noemi Puccio, Ilaria Craparotta, Marco Bolis, Roberto Piva, Antonino Neri, Luca Agnelli, Francesco Passamonti, Niccolò Bolli, Elisa Taiana   +14 more
wiley   +1 more source

Abnormalities of Sphingolipids Metabolic Pathways in the Pathogenesis of Psoriasis

Metabolites, 2023
Psoriasis is immune-mediated skin disorder affecting thousands of people. Sphingolipids (SLs) are bioactive molecules present in the epidermis, involved in the following cellular processes: proliferation, differentiation, and apoptosis of keratinocytes ...
Beatriz Burger, Roberta Nicolli Sagiorato, Isabella Cavenaghi, Hosana Gomes Rodrigues   +3 more
doaj   +1 more source