Results 61 to 70 of about 1,842 (145)

Connexin 26 Functions as a Direct Transcriptional Regulator During the Cochlea Development

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Connexin26 can not only form intercellular channels that mediate rapid communication on the cell membrane, but also enter the nucleus as a transcription factor to directly regulate the transcription of nuclear genes. In the developing cochlea, Cx26 can control the maturation of the molecular scissor ADAM10 by regulating the transcription of TspanC8 ...
Xiaozhou Liu, Le Xie, Yuan Jin, Sen Chen, Xinyu Shi, Yanjun Zong, Zhengdong Zhao, Wei‐Jia Kong, Yu Sun   +8 more
wiley   +1 more source

Sphingolipids in Emotional Well‐Being

Journal of Neurochemistry, Volume 170, Issue 2, February 2026.
Sphingolipids are essential constituents of neuronal membranes and are increasingly recognized as contributors to the key behavioral manifestations associated with emotional well‐being. ABSTRACT Emotional well‐being is a multifactorial concept, which comprises not only life quality of human individuals, but also their mental and physical health.
L. S. Kalinichenko, I. Zoicas, C. Mühle, J. Kornhuber, C. P. Müller   +4 more
wiley   +1 more source

SMPD3 suppresses oligodendroglioma growth via dual autocrine-paracrine roles

This dataset contains images of full western blots presented in performed and presented in "SMPD3 suppresses oligodendroglioma growth via dual autocrine-paracrine roles" study.
Saleh, Fermisk
core   +1 more source

Souris fragilitas ossium et mutation de la sphingomyélinase neutre de type 2 : implication dans l'apoptose et l'ostéochondrogenèse [PDF]

, 2011
Les sphingolipides sont des lipides complexes, qui rentrent dans la composition des membranes, mais sont également des agents de signalisation majeurs, impliqués dans de nombreuses réponses et régulations cellulaires, et dans la physiopathologie de ...
Devillard, Raphaël
core  

An Integrated Regulatory Network Based on Comprehensive Analysis of mRNA Expression, Gene Methylation and Expression of Long Non-coding RNAs (lncRNAs) in Myelodysplastic Syndromes

Frontiers in Oncology, 2019
Myelodysplastic syndromes (MDS) are a heterogeneous group of disorders characterized by ineffective hematopoiesis, defective differentiation of hematopoietic precursors, and expansion of the abnormal clones.
Xiaoli Zhao, Xiaoli Zhao, Hua Yin, Nianyi Li, Yu Zhu, Wenyi Shen, Sixuan Qian, Guangsheng He, Jianyong Li, Xiaoqin Wang   +9 more
doaj   +1 more source

Micro/nano-textured hierarchical titanium topography promotes exosome biogenesis and secretion to improve osseointegration

Journal of Nanobiotechnology, 2021
Background Micro/nano-textured hierarchical titanium topography is more bioactive and biomimetic than smooth, micro-textured or nano-textured titanium topographies. Bone marrow mesenchymal stem cells (BMSCs) and exosomes derived from BMSCs play important
Zhengchuan Zhang, Ruogu Xu, Yang Yang, Chaoan Liang, Xiaolin Yu, Yun Liu, Tianlu Wang, Yi Yu, Feilong Deng   +8 more
doaj   +1 more source

A Scaffold‐Based 3D Culture Model Including Selected Osteoprogenitors for Bone Regeneration With Controlled Morphology

Stem Cells International, Volume 2026, Issue 1, 2026.
We previously identified “highly purified osteoprogenitors” (HipOPs) as a promising model for studying bone organ regeneration in murine systems. However, achieving proper integration of the bone formed by HipOPs into the well‐organized host bone requires better morphological control.
Thi Hue Mai, Shousaku Itoh, Takumi Kagioka, Makato Abe, Mikako Hayashi, Pasquale Marrazzo   +5 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Effect of Procysteine on aging-associated changes in hepatic GSH and SMase: evidence for transcriptional regulation of smpd3[S]

Journal of Lipid Research, 2014
In hepatocytes, aging-associated decline in GSH has been linked to activation of neutral SMase (nSMase), accumulation of bioactive ceramide, and inflammation. In this study, we seek to test whether dietary supplementation with the cysteine precursor, L-2-
Gergana Deevska, Manjula Sunkara, Claudia Karakashian, Benjamin Peppers, Andrew J. Morris, Mariana N. Nikolova-Karakashian   +5 more
doaj   +1 more source

PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity

Advanced Science, Volume 12, Issue 41, November 6, 2025.
Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley   +1 more source