Results 41 to 50 of about 1,881 (140)

Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL

Redox Biology, 2015
The neutral type 2 sphingomyelinase (nSMase2) hydrolyzes sphingomyelin and generates ceramide, a major bioactive sphingolipid mediator, involved in growth arrest and apoptosis.
Sandra Garoby-Salom, Myriam Rouahi, Elodie Mucher, Nathalie Auge, Robert Salvayre, Anne Negre-Salvayre   +5 more
doaj   +2 more sources

Review for "SMPD3 ‐ ALK : A novel ALK fusion gene in lung adenocarcinoma"

, 2020
Ullas Batra
semanticscholar   +6 more sources

Abnormal methylation status of FBXW10 and SMPD3, and associations with clinical characteristics in clear cell renal cell carcinoma.

Oncology Letters, 2015
The present study aimed to evaluate the use of the 27K methylation array to investigate abnormal methylation of two genes and their associations with clinical characteristics in clear cell renal cell carcinoma (ccRCC). Six differentially-methylated genes
Jin-you Wang, Jian Li, J. Gu, Jian Yu, Shicheng Guo, Yao Zhu, D. Ye   +6 more
semanticscholar   +4 more sources

Clinical insight-driven novel drug development: Multidisciplinary integration and transformative opportunities [PDF]

Acta Pharmaceutica Sinica B
Baohu Li, Hui Xu, Xiaoyu Shi, Chunhua Ma, Jinfei Yang, Peng Zhan   +5 more
doaj   +2 more sources

Neonatal stroke enhances interaction of microglia-derived extracellular vesicles with microglial cells

Neurobiology of Disease, 2021
Microglial cells support brain homeostasis under physiological conditions and modulate brain injury in a context-dependent and brain maturation-dependent manner. Microglial cells protect neonatal brain from acute stroke.
Matthieu Lecuyer, Praneeti Pathipati, Joel Faustino, Zinaida S. Vexler   +3 more
doaj   +1 more source

Smpd3 Expression in both Chondrocytes and Osteoblasts Is Required for Normal Endochondral Bone Development

Molecular and Cellular Biology, 2016
Jingjing Li, Chundo Oh, Pierre Moffatt   +2 more
exaly   +2 more sources

Activation of Sphingomyelin Phosphodiesterase 3 in Liver Regeneration Impedes the Progression of Colorectal Cancer Liver Metastasis Via Exosome-Bound Intercellular Transfer of CeramidesSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: The machinery that prevents colorectal cancer liver metastasis (CRLM) in the context of liver regeneration (LR) remains elusive. Ceramide (CER) is a potent anti-cancer lipid involved in intercellular interaction.
Qingping Li, Jieyuan Li, Kai Wang, Leyi Liao, Yiyi Li, Hanbiao Liang, Can Huang, Jian Gan, Xiaoyu Dong, Yaowen Hu, Jiaxin Cheng, Hongli Ji, Cuiting Liu, Minghui Zeng, Sheng Yu, Biao Wang, Jianping Qian, Zhongshun Tang, Yonghong Peng, Shanhua Tang, Mengxuan Li, Jie Zhou, Jun Yan, Chuanjiang Li   +23 more
doaj   +1 more source

Disruption of adipocyte HIF-1α improves atherosclerosis through the inhibition of ceramide generation

Acta Pharmaceutica Sinica B, 2022
Atherosclerosis is a chronic multifactorial cardiovascular disease. Western diets have been reported to affect atherosclerosis through regulating adipose function.
Pengcheng Wang, Guangyi Zeng, Yu Yan, Song-yang Zhang, Yongqiang Dong, Yangming Zhang, Xingzhong Zhang, Huiying Liu, Zhipeng Zhang, Changtao Jiang, Yanli Pang   +10 more
doaj   +1 more source

Neuronal deletion of nSMase2 reduces the production of Aβ and directly protects neurons

Neurobiology of Disease, 2023
Extracellular vesicles (EVs) have been proposed to regulate the deposition of Aβ. Multiple publications have shown that APP, amyloid processing enzymes and Aβ peptides are associated with EVs.
Sehmus Tohumeken, Pragney Deme, Seung Wan Yoo, Sujasha Gupta, Rana Rais, Barbara S. Slusher, Norman J. Haughey   +6 more
doaj   +1 more source

Neutral sphingomyelinase 2 (smpd3) in the control of postnatal growth and development

Proceedings of the National Academy of Sciences of the United States of America, 2005
Jürgen Koebke
exaly   +2 more sources