Results 21 to 30 of about 1,842 (145)

Clinical insight-driven novel drug development: Multidisciplinary integration and transformative opportunities [PDF]

Acta Pharmaceutica Sinica B
Baohu Li, Hui Xu, Xiaoyu Shi, Chunhua Ma, Jinfei Yang, Peng Zhan   +5 more
doaj   +2 more sources

Neonatal stroke enhances interaction of microglia-derived extracellular vesicles with microglial cells

Neurobiology of Disease, 2021
Microglial cells support brain homeostasis under physiological conditions and modulate brain injury in a context-dependent and brain maturation-dependent manner. Microglial cells protect neonatal brain from acute stroke.
Matthieu Lecuyer, Praneeti Pathipati, Joel Faustino, Zinaida S. Vexler   +3 more
doaj   +1 more source

Activation of Sphingomyelin Phosphodiesterase 3 in Liver Regeneration Impedes the Progression of Colorectal Cancer Liver Metastasis Via Exosome-Bound Intercellular Transfer of CeramidesSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background & Aims: The machinery that prevents colorectal cancer liver metastasis (CRLM) in the context of liver regeneration (LR) remains elusive. Ceramide (CER) is a potent anti-cancer lipid involved in intercellular interaction.
Qingping Li, Jieyuan Li, Kai Wang, Leyi Liao, Yiyi Li, Hanbiao Liang, Can Huang, Jian Gan, Xiaoyu Dong, Yaowen Hu, Jiaxin Cheng, Hongli Ji, Cuiting Liu, Minghui Zeng, Sheng Yu, Biao Wang, Jianping Qian, Zhongshun Tang, Yonghong Peng, Shanhua Tang, Mengxuan Li, Jie Zhou, Jun Yan, Chuanjiang Li   +23 more
doaj   +1 more source

Disruption of adipocyte HIF-1α improves atherosclerosis through the inhibition of ceramide generation

Acta Pharmaceutica Sinica B, 2022
Atherosclerosis is a chronic multifactorial cardiovascular disease. Western diets have been reported to affect atherosclerosis through regulating adipose function.
Pengcheng Wang, Guangyi Zeng, Yu Yan, Song-yang Zhang, Yongqiang Dong, Yangming Zhang, Xingzhong Zhang, Huiying Liu, Zhipeng Zhang, Changtao Jiang, Yanli Pang   +10 more
doaj   +1 more source

Neuronal deletion of nSMase2 reduces the production of Aβ and directly protects neurons

Neurobiology of Disease, 2023
Extracellular vesicles (EVs) have been proposed to regulate the deposition of Aβ. Multiple publications have shown that APP, amyloid processing enzymes and Aβ peptides are associated with EVs.
Sehmus Tohumeken, Pragney Deme, Seung Wan Yoo, Sujasha Gupta, Rana Rais, Barbara S. Slusher, Norman J. Haughey   +6 more
doaj   +1 more source

Integrative Analysis of Blood Transcriptomics and Metabolomics Reveals Molecular Regulation of Backfat Thickness in Qinchuan Cattle

Animals, 2023
A crucial goal of reducing backfat thickness (BFT) is to indirectly improve feed conversion efficiency. This phenotype has been reported in certain papers; however, the molecular mechanism has yet to be fully revealed.
Hengwei Yu, Sayed Haidar Abbas Raza, Yueting Pan, Gong Cheng, Chugang Mei, Linsen Zan   +5 more
doaj   +1 more source

SMPD3 is a differentially expressed gene in brain metastatic human breast cancer.

, 2021
Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans ...
Shahan Mamoor
core   +1 more source

Fenretinide inhibits obesity and fatty liver disease but induces Smpd3 to increase serum ceramides and worsen atherosclerosis in LDLR−/− mice

Scientific Reports, 2023
Fenretinide is a synthetic retinoid that can prevent obesity and improve insulin sensitivity in mice by directly altering retinol/retinoic acid homeostasis and inhibiting excess ceramide biosynthesis.
Dawn Thompson, Shehroz Mahmood, Nicola Morrice, Sarah Kamli-Salino, Ruta Dekeryte, Philip A. Hoffmann, Mary K. Doherty, Philip D. Whitfield, Mirela Delibegović, Nimesh Mody   +9 more
doaj   +1 more source

Gene expression of ceramide metabolism enzymes in fat depots of different localization in cardiovascular diseases

Российский кардиологический журнал, 2023
Aim. To assess gene expression of enzymes of the sphingomyelinase pathway of ceramide biosynthesis and degradation in fat depots of various localization in patients with cardiovascular diseases.Material and methods.
O. V. Gruzdeva, E. V. Belik, Yu. A. Dyleva, E. G. Uchasova, A. V. Ponasenko, A. G. Kutikhin, V. E. Markova, E. E. Gorbatovskaya, E. V. Fanaskova, S. V. Ivanov, A. N. Stasev, M. G. Zinets, T. A. Slesareva, O. L. Barbarash   +13 more
doaj   +1 more source

Potential biomarkers of abnormal osseointegration of implants in type II diabetes mellitus

BMC Oral Health, 2021
Background Type II diabetes mellitus (T2DM) is an important risk factor for osseointegration of implants. The aim of this study was to explore key genes of T2DM affecting bone metabolism through bioinformatic analysis of published RNA sequencing data ...
Lingxiao Wang, Zhenhua Gao, Changying Liu, Jun Li   +3 more
doaj   +1 more source