Results 21 to 30 of about 1,881 (140)

Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias

Blood, 2008
AbstractCeramide is a lipid second messenger derived from the hydrolysis of sphingomyelin by sphingomyelinases (SMases) and implicated in diverse cellular responses, including growth arrest, differentiation, and apoptosis. Defects in the neutral SMase (nSMase) gene Smpd3, the primary regulator of ceramide biosynthesis, are responsible for developmental
Louise Purton, David Sweetser, Look A Thomas   +2 more
exaly   +5 more sources

Inflammation related proteins and PLCG1 may contribute to papillary thyroid carcinoma risk through a potential regulatory axis [PDF]

Discover Oncology
Background Papillary thyroid carcinoma (PTC) is usually indolent, but a subset of patients shows aggressive behavior. Understanding protein-level mechanisms is essential for identifying new therapeutic targets. Materials and methods We integrated protein
Shi-Qi Wang, Miao Yang, De-Wei Rao, Yan-Jun Su, Ruo-Chuan Cheng   +4 more
doaj   +2 more sources

Choroid plexus modulates subventricular zone adult neurogenesis and olfaction through secretion of small extracellular vesicles [PDF]

Fluids and Barriers of the CNS
The choroid plexus (CP) in the brain ventricles secretes cerebrospinal fluid (CSF) that bathes the adjacent subventricular zone (SVZ). As the largest adult neurogenic region enriched with neural stem/progenitor cells (NSPCs), the SVZ supplies newborn ...
Luke L. Liu, Jonathan Shannahan, Wei Zheng   +2 more
doaj   +2 more sources

SMPD3 is a differentially expressed gene in brain metastatic human breast cancer.

, 2021
Metastasis to the brain is a clinical problem in patients with breast cancer (1-3). We mined published microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans ...
Shahan Mamoor
semanticscholar   +3 more sources

SMPD3‐ALK: A novel ALK fusion gene in lung adenocarcinoma

Clinical Genetics, 2020
Anaplastic lymphoma kinase (ALK) is one of the most important driver genes and therapeutic targets in patients with non-small-cell lung cancer (NSCLC), who tend to be young and either light smokers or nonsmokers.
Yue-pei Liang, Yang Wang, Wenjing Wang, Juan Zhao, Mian Xu, Minglei Zheng   +5 more
semanticscholar   +2 more sources

Beyond type 2 asthma biomarkers: risk stratification for NSAID-exacerbated respiratory disease [PDF]

ERJ Open Research
Introduction Type 2 (T2) asthma is often associated with chronic rhinosinusitis with nasal polyposis (CRSwNP). Additionally, nonsteroidal anti-inflammatory drug (NSAID) intolerance leads to NSAID-exacerbated respiratory disease (N-ERD).
Jacqueline Pérez-Pazos, Asunción García-Sánchez, Miguel Estravís, Emma Moreno-Jimenez, Natalia Morgado, Manuel Gómez-García, Jacinto Ramos-González, María Gil-Melcón, Cristina Martín-García, Francisco Muñoz-Bellido, Catalina Sanz, María Isidoro-García, Ignacio Dávila   +12 more
doaj   +2 more sources

The Ceramide-Dependent EV Secretome Differentially Affects Prostate Cancer Cell Migration [PDF]

Cells
Tumor-derived extracellular vesicles (EVs) play an important role in cancer progression. Neutral sphingomyelinases (nSMases) are lipid-modifying enzymes that modulate the secretion of EVs from cells.
Dolma Choezom, Jan-Moritz Plum, Pradhipa Karuna M., Adi Danieli-Mackay, Christof Lenz, Phillipp Brockmeyer, Julia Christina Gross   +6 more
doaj   +2 more sources

Impact of Neutral Sphingomyelinase Inhibition on Small Extracellular Vesicle Production by Mural Granulosa Cells and In Vitro Folliculogenesis in Mice. [PDF]

Mol Reprod Dev
ABSTRACT Small extracellular vesicles (sEVs) function as critical regulators of ovarian follicular development. Although several pathways, including one involving neutral sphingomyelinase (nSMase), contribute to sEV production, the specific pathway active in ovarian follicles has not been clearly identified.
Matsushita K, Matsuno Y, Kita K, Ichikawa A, Maruyama N, Fujii W, Endo T, Sugiura K.   +7 more
europepmc   +2 more sources

Metabolic reprogramming promotes apoptosis resistance in acute lymphoblastic leukemia through CASP3 lactylation [PDF]

Molecular Cancer
Acute lymphoblastic leukemia (ALL) is characterized by metabolic adaptations that support rapid cell proliferation and resistance to apoptosis. Our study identifies elevated sphingomyelin (SM) as a key metabolic alteration in ALL, contributing to ...
Zhi Lin, Fei Long, Jiao Liu, Rui Kang, Daniel J. Klionsky, Guido Kroemer, Daolin Tang, Minghua Yang   +7 more
doaj   +2 more sources

SMPD3 suppresses oligodendroglioma growth via dual autocrine-paracrine roles.

Communications Biology
Oligodendrogliomas (ODGs) are slow-growing tumors with poorly defined biology. Here, we identify SMPD3, encoding neutral sphingomyelinase 2 (nSMase2), as a negative regulator of ODG progression via extracellular vesicle (EV) biogenesis and autocrine ...
F. Saleh, Anjali Balakrishnan, L. Adnani, S. Ahmad, Vorapin Chinchalongporn, A. El-Sehemy, Thomas Olender, Myra J. Chen, Aditya Kshirsagar, Andrew Kennedy, Nilakshi Kulathunga, O. Prokopchuk, Lakshmy Vasan, Yacine Touahri, Rehnuma Islam, Sajeevan Sujanthan, D. Zinyk, L. Comanita, B. Kan, Taylor Fleming, Iacovos P Michael, C. M. Morshead, Hon S Leong, Satoshi Okawa, Marjorie Brand, Valerie A. Wallace, Jennifer A Chan, Carol Schuurmans   +27 more
semanticscholar   +2 more sources