Results 81 to 90 of about 1,842 (145)

ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta [PDF]

, 2008
Osteogenesis imperfecta is an inherited disorder characterized by increased bone fragility, fractures, and osteoporosis, and most cases are caused by mutations affecting the type I collagen genes.
Ralston, Stuart H., Thomas S Lisse, Eckhard Wolf, Quintanilla-Martinez Leticia, de Angelis Martin Hrabé, Fuchs Helmut, Lisse Thomas S, Gabriele Hoelzlwimmer, Hrabě de Angelis, M., Martin Hrabé de Angelis, Hölzlwimmer, G., Abe, Koichiro, Rathkolb, Birgit, de Angelis, Martin Hrabe, Hans, Wolfgang, Rathkolb, B., Quintanilla-Martinez, Leticia, Ralston, Stuart H, Koichiro Abe, Abe, K., Wolf Eckhard, Przemeck, G.K.H., Hans Wolfgang, Hoelzlwimmer, Gabriele, Przemeck Gerhard K. H, Fuchs, H., Abe Koichiro, Hoelzlwimmer Gabriele, Hrabé de Angelis, Martin, Wolf, E., Miep Helfrich, Lisse, Thomas S, Quintanilla-Martinez, L., Thiele, F., Ralston, S.H., Helmut Fuchs, Gerhard K H Przemeck, Helfrich, M., Helfrich, Miep, Przemeck, Gerhard K. H., Lisse, Thomas S., Thiele, Frank, Frank Thiele, Helfrich Miep, Stuart H Ralston, Wolfgang Hans, Hans, W., Przemeck, Gerhard K H, Thiele Frank, Rathkolb Birgit, Ralston Stuart H, Lisse, T.S., Birgit Rathkolb, Fuchs, Helmut, Wolf, Eckhard, Leticia Quintanilla-Martinez, Lisse, T.S. ; Thiele, F. ; Fuchs, H. ; Hans, W. ; Przemeck, G.K.H. ; Abe, K. ; Rathkolb, B. ; Quintanilla-Martinez, L. ; Hölzlwimmer, G. ; Helfrich, M. ; Wolf, E. ; Ralston, S.H. ; Hrabé de Angelis, M.   +56 more
core   +2 more sources

Sphingomyelin phosphodiesterase 3, a critical regulator of bone and tooth mineralization

, 2016
A recessive mutation called fragilitas ossium (fro) in the sphingomyelin phosphodiesterase 3 (Smpd3) gene leads to impaired mineralization of bone and tooth extracellular matrix in fro/fro mice. SMPD3 (also known as nSMase2) cleaves sphingomyelin present
Khavandgar, Zohreh
core  

B lymphocytes impair osteogenesis by inhibiting BMSC differentiation in osteoporosis

Immunobiology
Background: B lymphocytes have been implicated in the inhibition of osteogenesis, but their role in osteoporosis (OP) remains unclear. This study investigates the association between B lymphocytes and impaired osteogenesis in OP patients and explores the
Cong Peng, Qiao Yang, Linyu Li, Yufeng Li, Zhaoyang Ye, Kun Zhao, Yi Yi, Liang Wang   +7 more
doaj   +1 more source

Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL

Redox Biology, 2015
The neutral type 2 sphingomyelinase (nSMase2) hydrolyzes sphingomyelin and generates ceramide, a major bioactive sphingolipid mediator, involved in growth arrest and apoptosis.
Sandra Garoby-Salom, Myriam Rouahi, Elodie Mucher, Nathalie Auge, Robert Salvayre, Anne Negre-Salvayre   +5 more
doaj   +1 more source

DNA methylation profiling in archived FFPE renal biopsies: a pilot study of epigenetic markers of albuminuria in diabetic kidney disease

Epigenetics Reports
Diabetes Mellitus is the leading risk factor for kidney failure, yet current biomarkers such as urinary albumin-to-creatinine ratio (UACR) lack tissue specificity and sensitivity for early detection of Diabetic Kidney Disease (DKD).
Ishant Khurana, Ram Abou Zaki, Harikrishnan Kaipananickal, Rachel Njeim, Batoul Dia, Hala Kfoury Kassouf, Assaad A. Eid, Assam El-Osta   +7 more
doaj   +1 more source

Krm2 overexpression and Lrp5 deficiency result in increased osteoclast number.

, 2014
(A) Osteoclasts were identified by histochemical staining of tartrat-resistant acid phosphatase (TRAP) at day 10 post fracture. (B) Osteoclast number was determined in the peripheral callus at day 10 post fracture.
Franz Jakob (133384), Ludger Klein-Hitpass (133366), Anita Ignatius (142960), Astrid Liedert (504726), Peggy Benisch (133364), Michael Amling (133377), Regina Ebert (133381), Jochen K. Lennerz (353982), Thorsten Schinke (126724), Viktoria Röntgen (604178)   +9 more
core   +1 more source

Prenatal tobacco smoke exposure is associated with childhood DNA CpG methylation.

PLoS ONE, 2014
BackgroundSmoking while pregnant is associated with a myriad of negative health outcomes in the child. Some of the detrimental effects may be due to epigenetic modifications, although few studies have investigated this hypothesis in detail.ObjectivesTo ...
Carrie V Breton, Kimberly D Siegmund, Bonnie R Joubert, Xinhui Wang, Weiliang Qui, Vincent Carey, Wenche Nystad, Siri E Håberg, Carole Ober, Dan Nicolae, Kathleen C Barnes, Fernando Martinez, Andy Liu, Robert Lemanske, Robert Strunk, Scott Weiss, Stephanie London, Frank Gilliland, Benjamin Raby, Asthma BRIDGE consortium   +19 more
doaj   +1 more source

Identification of molecular and morphological alterations in head and neck cancer

, 2020
Head and neck squamous cell carcinoma (HNSC) represents the 6th most common cancer type worldwide. A better understanding of the molecular alterations that occur in cells of the tumor and surrounding environment will allow for the identification of new ...
Jabalee, James
core   +1 more source

ROLE OF SPHINGOLIPID METABOLISM IN MELANOMA PROGRESSION [PDF]

Gli sfingolipidi sono lipidi polari coinvolti in numerosi processi biologici. Ne consegue che sia gli sfingolipidi che gli enzimi coinvolti nel loro metabolismo, sono importanti per l’omeostasi cellulare e partecipano in numerosi processi fisio ...
CORLI, MARZIA
core   +1 more source

High Dose C6 Ceramide-Induced Response in Embryonic Hippocampal Cells

Biomolecules
Ceramide is a critical molecule in both the physiology and pathology of the central nervous system. The most studied aspect is its effect on embryonic/stem cells. A salient question is whether low doses of ceramide induce neuronal differentiation without
Federico Fiorani, Martina Mandarano, Samuela Cataldi, Alessandra Mirarchi, Stefano Bruscoli, Francesco Ragonese, Bernard Fioretti, Toshihide Kobayashi, Nario Tomishige, Tommaso Beccari, Claudia Floridi, Cataldo Arcuri, Elisabetta Albi   +12 more
doaj   +1 more source