Results 81 to 90 of about 1,881 (140)

Genetic factors for hematological traits in pigs

Animal Genetics, Volume 56, Issue 5, October 2025.
Abstract Complete blood count with differential is a critical diagnostic tool for evaluating the physiological and health status of individuals by analyzing white blood cells, red blood cells, and platelets. While extensively used in human medicine, the application of complete blood count biomarkers in pigs remain limited.
Jiahong Sun, Emil Ibragimov, Peter Karlskov‐Mortensen, Merete Fredholm   +3 more
wiley   +1 more source

Beyond the Secretory Pathway: New Insights Into Protein Release

Traffic, Volume 26, Issue 10-12, October/December 2025.
While proteins bearing N‐terminal signal or leader sequences are secreted via the ER‐Golgi‐plasma membrane axis of the conventional secretion pathway, many cytosolic proteins lacking signaling sequence can be secreted via poorly defined mechanisms termed Unconventional Protein Secretion (UcPS).
Ruey‐Hwa Chen, Antonio J. Costa‐Filho, Jayanta Debnath, Thierry Galli, Liang Ge, Deborah Goberdhan, Wei Guo, Kangmin He, Ralf Jacob, Tiebang Kang, Min Goo Lee, Lian Li, Fabio Lolicato, Jun Lu, Vivek Malhotra, Walter Nickel, Vassiliki Nikoletopoulou, Stacey K. Ogden, Georgia Maria Sagia, Feng Shao, Anbing Shi, Clotilde Thery, Christel Vérollet, Julien Villeneuve, Frederik Verweij, Yanzhuang Wang, Juan Wang, Shenjie Wu, Yihong Ye, Hang Yin, Li Yu, Min Zhang, Ying Zhang, Xin Zhou, Chiara Zurzolo   +34 more
wiley   +1 more source

N6‐methyladenosine‐regulated exosome biogenesis orchestrates an immunosuppressive pre‐metastatic niche in gastric cancer peritoneal metastasis

Cancer Communications, Volume 45, Issue 8, Page 941-965, August 2025.
Abstract Background Gastric cancer peritoneal metastasis is clinically challenging, given the limited treatment options and poor prognosis. The molecular mechanisms that precede gastric cancer peritoneal metastasis, known as the pre‐metastatic niche (PMN), and its relationship with N6‐methyladenosine (m6A) modification remain unclear.
Song Li, Jianyuan Zhou, Shuang Wang, Qian Yang, Shulun Nie, Chunwang Ji, Xue Zhang, Shuhan Li, Xuanyu Zhou, Jiahui Chu, Xuehui Wu, Jianqiao Jiao, Ruitao Xu, Qian Xu, Miao Huang, Qiushi Wang, Liliang Dou, Qinqin Hu, Fan Jiang, Xin Dai, Zhaodi Nan, Xinyu Song, Di Zhang, Lian Liu   +23 more
wiley   +1 more source

Neutral Sphingomyelinase 2 Inhibition Limits Hepatic Steatosis and Inflammation

Cells
Non-alcoholic fatty liver disease (NAFLD) is manifested by hepatic steatosis, insulin resistance, hepatocyte death, and systemic inflammation. Obesity induces steatosis and chronic inflammation in the liver.
Fatema Al-Rashed, Hossein Arefanian, Ashraf Al Madhoun, Fatemah Bahman, Sardar Sindhu, Halemah AlSaeed, Texy Jacob, Reeby Thomas, Areej Al-Roub, Fawaz Alzaid, MD Zubbair Malik, Rasheeba Nizam, Thangavel Alphonse Thanaraj, Fahd Al-Mulla, Yusuf A. Hannun, Rasheed Ahmad   +15 more
doaj   +1 more source

T‐cell differentiation stage block bias confers hypermethylation and mediastinal preference in T‐cell lymphoblastic lymphoma

Clinical and Translational Medicine, Volume 15, Issue 7, July 2025.
Malignant T cells in T‐cell lymphoblastic lymphoma (T‐LBL) are predominantly blocked in double negative (DN) and double positive (DP) stages. Block bias induces an immunosuppressive tumour microenvironment (TME) and mediastinal preference. Block bias upregulates UHRF1 leading to hypermethylation of tumour suppressor genes.
Jiali Wang, Bo Qian, Xiaowen Yu, Yidan Zhang, Chunlei Zhou, Tingting Yang, Le Xia, Gang Zhang, Yi‐Xuan Zhang, Yaping Wang, Yongjun Fang   +10 more
wiley   +1 more source

Notum as a Crucial Regulator of Matrix Integrity in Dentinogenesis

Journal of Cellular Physiology, Volume 240, Issue 7, July 2025.
With Notum deficiency, mouse dentin exhibits a thicker yet dysplastic structure with disrupted tubular organization, resulting in functionally compromised dentin. Notum precisely regulates Wnt/β‐catenin signaling within the dentin‐pulp complex to support dentin formation.
Hwajung Choi, Ju‐Kyung Jeong, Dinuka Adasooriya, Sung‐Won Cho, Eui‐Sic Cho   +4 more
wiley   +1 more source

Dietary inulin decreases circulating ceramides by suppressing neutral sphingomyelinase expression and activity in mice

Journal of Lipid Research, 2020
Elevated circulating levels of ceramides (Cers) are associated with increased risk of cardiometabolic diseases, and Cers may play a causative role in metabolic dysfunction that precedes cardiac events, such as mortality as a result of coronary artery ...
Pan Deng, Jessie B. Hoffman, Michael C. Petriello, Chun-Yan Wang, Xu-Sheng Li, Maria P. Kraemer, Andrew J. Morris, Bernhard Hennig   +7 more
doaj   +1 more source

Proteogenomic network analysis reveals dysregulated mechanisms and potential mediators in Parkinson’s disease

Nature Communications
Parkinson’s disease is highly heterogeneous across disease symptoms, clinical manifestations and progression trajectories, hampering the identification of therapeutic targets.
Abolfazl Doostparast Torshizi, Dongnhu T. Truong, Liping Hou, Bart Smets, Christopher D. Whelan, Shuwei Li   +5 more
doaj   +1 more source

B lymphocytes impair osteogenesis by inhibiting BMSC differentiation in osteoporosis

Immunobiology
Background: B lymphocytes have been implicated in the inhibition of osteogenesis, but their role in osteoporosis (OP) remains unclear. This study investigates the association between B lymphocytes and impaired osteogenesis in OP patients and explores the
Cong Peng, Qiao Yang, Linyu Li, Yufeng Li, Zhaoyang Ye, Kun Zhao, Yi Yi, Liang Wang   +7 more
doaj   +1 more source

DNA methylation profiling in archived FFPE renal biopsies: a pilot study of epigenetic markers of albuminuria in diabetic kidney disease

Epigenetics Reports
Diabetes Mellitus is the leading risk factor for kidney failure, yet current biomarkers such as urinary albumin-to-creatinine ratio (UACR) lack tissue specificity and sensitivity for early detection of Diabetic Kidney Disease (DKD).
Ishant Khurana, Ram Abou Zaki, Harikrishnan Kaipananickal, Rachel Njeim, Batoul Dia, Hala Kfoury Kassouf, Assaad A. Eid, Assam El-Osta   +7 more
doaj   +1 more source