Characterization of Sphingomyelin Phosphodiesterase Expression in Bumblebee (Bombus lantschouensis) [PDF]
Journal of Insect Science, 2018 Sphingomyelin phosphodiesterase (SMPD) is a hydrolase that plays a major role in metabolic reactions involving sphingomyelin. Here, we describe an analysis of the cDNA sequence and gene structure of SMPD in bumblebee (Bombus lantschouensis). The expression of SMPD in different tissues and at different developmental stages and reproductive statuses was ...
Jiaxing Huang +2 more
exaly +4 more sources
Sphingomyelin Phosphodiesterase Acid-like 3A (SMPDL3A) Is a Novel Nucleotide Phosphodiesterase Regulated by Cholesterol in Human Macrophages [PDF]
Journal of Biological Chemistry, 2014 Cholesterol-loaded foam cell macrophages are prominent in atherosclerotic lesions and play complex roles in both inflammatory signaling and lipid metabolism, which are underpinned by large scale reprogramming of gene expression. We performed a microarray study of primary human macrophages that showed that transcription of the sphingomyelin ...
Leonard Kritharides +2 more
exaly +8 more sources
Sociobiology, 2017 The bumblebee (Bombus lantschouensis Vogt) is an important pollinator of wild plants. Sphingomyelin phosphodiesterase (SMPD) is a hydrolase that plays a major role in sphingolipid metabolism reactions.
lei Han +5 more
doaj +3 more sources
Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol [PDF]
BMC Medical Genetics, 2007 Background Niemann-Pick disease type A and B is caused by a deficiency of acid sphingomyelinase due to mutations in the sphingomyelin phosphodiesterase-1 (SMPD1) gene.
Genest Jacques +4 more
doaj +3 more sources
Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis. [PDF]
J Clin Invest, 2021 Intestinal farnesoid X receptor (FXR) signaling is involved in the development of obesity, fatty liver disease, and type 2 diabetes. However, the role of intestinal FXR in atherosclerosis and its potential as a target for clinical treatment have not been explored.
Wu Q +18 more
europepmc +4 more sources
Corrigendum to: "Characterization of Sphingomyelin Phosphodiesterase Expression in Bumblebee (Bombus lantschouensis)". [PDF]
J Insect Sci, 2019 europepmc +4 more sources
A novel estrogen receptor 1: sphingomyelin phosphodiesterase acid-like 3B pathway mediates rituximab response in myositis patients. [PDF]
Rheumatology (Oxford), 2023 Abstract Objectives The B-cell depleting biologic, rituximab, is used to treat refractory autoimmune myositis. However, the beneficial effects of rituximab appear to outweigh the known contribution of B cells in myositis. We aimed to elucidate how myositis patients respond differently to rituximab and
Parkes JE +9 more
europepmc +3 more sources
Sphingomyelin phosphodiesterase 3 as a novel host factor inhibiting hepatitis B virus transcription. [PDF]
Virol Sin• SMPD3 is identified as a novel host factor that inhibits Hepatitis B virus (HBV) replication at the transcriptional level. • SMPD3 knockdown enhances HBV replication in various cell models, increasing levels of HBsAg, HBeAg, and HBV DNA. • Mechanistic studies reveal SMPD3's inhibition of HBV transcription without affecting RNA stability or promoter ...
Li C +6 more
europepmc +3 more sources
Secretion of small/microRNAs including miR-638 into extracellular spaces by sphingomyelin phosphodiesterase 3. [PDF]
Oncol Rep, 2015 A recent study demonstrated that intracellular small/microRNAs are released from cells, and some of these extracellular RNAs are embedded in vesicles, such as ceramide-rich exosomes, on lipid-bilayer membranes. In the present study, we examined the effects of sphingomyelin phosphodiesterase 3 (SMPD3), which generates ceramide from sphingomyelin, on the
Kubota S +4 more
europepmc +4 more sources
eLife, 2021 Sphingolipids are important structural components of cell membranes and prominent signaling molecules controlling cell growth, differentiation, and apoptosis.
Wei Fan +9 more
doaj +1 more source