Results 11 to 20 of about 36,200 (174)

Sphingomyelin in Human Breast Milk might be Essential for the Hippocampus Maturation [PDF]

Frontiers in Bioscience-Landmark, 2022
Background: It has been established that sphingomyelin present human breast milk is useful for the brain maturation and cognitive development. At 10 days of breastfeeding the sphingomyelin content is double that present in cow’s milk and its content is ...
Elisabetta Albi, Cataldo Arcuri, Toshihide Kobayashi, Nario Tomishige, Michele Dei Cas, Rita Paroni, Paola Signorelli, Laura Cerquiglini, Stefania Troiani, Chiara Gizzi, Maria Rachele Ceccarini, Alessandra Mirarchi, Lina Cossignani, Mercedes Garcia Gil, Tommaso Beccari, Samuela Cataldi   +15 more
doaj   +2 more sources

The Importance of Sphingomyelin Phosphodiesterase Acid-Like 3b (SMPDL-3b) Levels in Kidney Biopsy Specimens of Children With Nephrotic Syndrome

Fetal and Pediatric Pathology, 2023
It remains unclear whether the low amount of SMPDL-3b required for rituximab binding is the cause of treatment resistance in patients with treatment-resistant nephrotic syndrome with advanced podocyte injury. Given the limited number of studies on the relationship between rituximab and SMPDL-3b, this study was conducted to assess whether SMPDL-3b ...
Muhammet Kaya, İlknur Girişgen, Nagihan Yalçın, Tülay Becerir, Hande Şenol, Gülsün Gülten, Selcuk Yüksel   +6 more
openaire   +6 more sources

Radiation-Induced Nephrotoxicity: Role of Sphingomyelin Phosphodiesterase Acid-like 3b

International Journal of Radiation Oncology*Biology*Physics
Radiation nephropathy (RN) can be a significant late complication after radiation therapy (RT) for abdominal and paraspinal tumors. The mechanisms for the development of RN are thought to involve disruption of podocyte function, leading to podocyte cell death and, finally, impaired renal function.
Anis Ahmad, Shamroop Kumar Mallela, Saba Ansari, Mohammed Alnukhali, Misha Ali, Sandra Merscher, Alan Pollack, Youssef H. Zeidan, Alessia Fornoni, Brian Marples   +9 more
openaire   +3 more sources

First Characterization of Sphingomyeline Phosphodiesterase Expression in the Bumblebee, Bombus lantschouensis

Sociobiology, 2017
The bumblebee (Bombus lantschouensis Vogt) is an important pollinator of wild plants. Sphingomyelin phosphodiesterase (SMPD) is a hydrolase that plays a major role in sphingolipid metabolism reactions.
lei Han, Shaoyu He, Jie Dong, Ye Wang, Jiaxing Huang, Jie Wu   +5 more
doaj   +3 more sources

Sphingomyelin phosphodiesterase-1 (SMPD1) coding variants do not contribute to low levels of high-density lipoprotein cholesterol [PDF]

BMC Medical Genetics, 2007
Background Niemann-Pick disease type A and B is caused by a deficiency of acid sphingomyelinase due to mutations in the sphingomyelin phosphodiesterase-1 (SMPD1) gene.
Genest Jacques, Engert James C, Ruel Isabelle L, Dastani Zari, Marcil Michel   +4 more
doaj   +3 more sources

Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis. [PDF]

J Clin Invest, 2021
Intestinal farnesoid X receptor (FXR) signaling is involved in the development of obesity, fatty liver disease, and type 2 diabetes. However, the role of intestinal FXR in atherosclerosis and its potential as a target for clinical treatment have not been explored.
Wu Q, Sun L, Hu X, Wang X, Xu F, Chen B, Liang X, Xia J, Wang P, Aibara D, Zhang S, Zeng G, Yun C, Yan Y, Zhu Y, Bustin M, Zhang S, Gonzalez FJ, Jiang C.   +18 more
europepmc   +4 more sources

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science
Spontaneous ovarian hyperstimulation syndrome (OHSS) is closely associated with follicle stimulating hormone receptor (FSHR) functional mutations. We observed that estrildid finches naturally carry the gain‐of‐function FSHR p.Thr449Ala mutation found in ...
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
doaj   +2 more sources

A novel estrogen receptor 1: sphingomyelin phosphodiesterase acid-like 3B pathway mediates rituximab response in myositis patients. [PDF]

Rheumatology (Oxford), 2023
Abstract Objectives The B-cell depleting biologic, rituximab, is used to treat refractory autoimmune myositis. However, the beneficial effects of rituximab appear to outweigh the known contribution of B cells in myositis. We aimed to elucidate how myositis patients respond differently to rituximab and
Parkes JE, Boehler JF, Li N, Kendra RM, O'Hanlon TP, Hoffman EP, Peterson JM, Miller FW, Rider LG, Nagaraju K.   +9 more
europepmc   +3 more sources

Corrigendum to: "Characterization of Sphingomyelin Phosphodiesterase Expression in Bumblebee (Bombus lantschouensis)". [PDF]

J Insect Sci, 2019
europepmc   +4 more sources

Ciliary Membrane Lipid Homeostasis in Health and Disease. [PDF]

Adv Sci (Weinh)
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Huang Z, Liu YY, Sun H, Liu P.
europepmc   +2 more sources