Results 21 to 30 of about 4,601 (147)

Contribution of sphingomyelin phosphodiesterase acid-like 3B to the proliferation, migration, and invasion of ovarian cancer cells. [PDF]

Transl Cancer Res
Cancer has the highest mortality rate among gynecological cancers and poses a serious threat to women's lives. However, the treatment options for ovarian cancer are still limited, and exploring effective targeted biomarkers is particularly important for predicting and treating ovarian cancer.
Song B, Jiang Y, Lin Y, Liu J, Jiang Y.
europepmc   +3 more sources

Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response. [PDF]

Oncotarget, 2020
Neutral sphingomyelinase 2 (nSMase2), the product of the sphingomyelin phosphodiesterase 3 (SMPD3) gene, catalyzes the hydrolysis of sphingomyelin to ceramide. Ceramide acts on various signaling pathways to influence cell proliferation, survival, and stress response.
Jabalee J, Towle R, Lawson J, Dickman C, Garnis C.   +4 more
europepmc   +4 more sources

Four Novel p.N385K, p.V36A, c.1033–1034insT and c.1417–1418delCT Mutations in the Sphingomyelin Phosphodiesterase 1 (SMPD1) Gene in Patients with Types A and B Niemann-Pick Disease (NPD) [PDF]

International Journal of Molecular Sciences, 2015
Behnam Kamalidehghan, Fatemeh Keshavarzi, Massoud Houshmand   +2 more
exaly   +2 more sources

Case Report: Novel Biallelic Null Variants of SMPD4 Confirm Its Involvement in Neurodevelopmental Disorder With Microcephaly, Arthrogryposis, and Structural Brain Anomalies

Frontiers in Genetics, 2022
The SMPD4 gene encodes sphingomyelin phosphodiesterase 4, which preferentially hydrolyzes sphingomyelin over other phospholipids. The biallelic loss-of-function variants of SMPD4 have been identified in a group of children with neurodevelopmental ...
Weigang Ji, Xiangtian Kong, Honggang Yin, Jian Xu, Xueqian Wang, Xueqian Wang   +5 more
doaj   +1 more source

Sphingomyelin in Human Breast Milk might be Essential for the Hippocampus Maturation

Frontiers in Bioscience-Landmark, 2022
Background: It has been established that sphingomyelin present human breast milk is useful for the brain maturation and cognitive development. At 10 days of breastfeeding the sphingomyelin content is double that present in cow’s milk and its content is ...
Elisabetta Albi, Cataldo Arcuri, Toshihide Kobayashi, Nario Tomishige, Michele Dei Cas, Rita Paroni, Paola Signorelli, Laura Cerquiglini, Stefania Troiani, Chiara Gizzi, Maria Rachele Ceccarini, Alessandra Mirarchi, Lina Cossignani, Mercedes Garcia Gil, Tommaso Beccari, Samuela Cataldi   +15 more
doaj   +1 more source

Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

Cell Reports, 2021
Summary: The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible.
Junfeng Bi, Atif Khan, Jun Tang, Aaron M. Armando, Sihan Wu, Wei Zhang, Ryan C. Gimple, Alex Reed, Hui Jing, Tomoyuki Koga, Ivy Tsz-Lo Wong, Yuchao Gu, Shunichiro Miki, Huijun Yang, Briana Prager, Ellis J. Curtis, Derek A. Wainwright, Frank B. Furnari, Jeremy N. Rich, Timothy F. Cloughesy, Harley I. Kornblum, Oswald Quehenberger, Andrey Rzhetsky, Benjamin F. Cravatt, Paul S. Mischel   +24 more
doaj   +1 more source

Sphingomyelin and Medullary Sponge Kidney Disease: A Biological Link Identified by Omics Approach

Frontiers in Medicine, 2021
Background: Molecular biology has recently added new insights into the comprehension of the physiopathology of the medullary sponge kidney disease (MSK), a rare kidney malformation featuring nephrocalcinosis and recurrent renal stones.
Simona Granata, Maurizio Bruschi, Michela Deiana, Andrea Petretto, Gianmarco Lombardi, Alberto Verlato, Rossella Elia, Giovanni Candiano, Giovanni Malerba, Giovanni Gambaro, Gianluigi Zaza   +10 more
doaj   +1 more source

Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels

Cell Reports, 2020
Summary: Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines.
Jian Shi, Adam J. Hyman, Dario De Vecchis, Jiehan Chong, Laeticia Lichtenstein, T. Simon Futers, Myriam Rouahi, Anne Negre Salvayre, Nathalie Auge, Antreas C. Kalli, David J. Beech   +10 more
doaj   +1 more source

Ceramide-Induced Lysosomal Biogenesis and Exocytosis in Early-Onset Preeclampsia Promotes Exosomal Release of SMPD1 Causing Endothelial Dysfunction

Frontiers in Cell and Developmental Biology, 2021
Aberrant ceramide build-up in preeclampsia, a serious disorder of pregnancy, causes exuberant autophagy-mediated trophoblast cell death. The significance of ceramide accumulation for lysosomal biogenesis in preeclampsia is unknown.
Leonardo Ermini, Abby Farrell, Abby Farrell, Sruthi Alahari, Jonathan Ausman, Jonathan Ausman, Chanho Park, Chanho Park, Julien Sallais, Megan Melland-Smith, Tyler Porter, Michael Edson, Ori Nevo, Michael Litvack, Martin Post, Martin Post, Martin Post, Isabella Caniggia, Isabella Caniggia, Isabella Caniggia, Isabella Caniggia   +20 more
doaj   +1 more source

Alternative splicing of SMPD1 in human sepsis. [PDF]

PLoS ONE, 2015
Acid sphingomyelinase (ASM or sphingomyelin phosphodiesterase, SMPD) activity engages a critical role for regulation of immune response and development of organ failure in critically ill patients.
Marcel Kramer, Stefanie Quickert, Christoph Sponholz, Uwe Menzel, Klaus Huse, Matthias Platzer, Michael Bauer, Ralf A Claus   +7 more
doaj   +1 more source