Sphingomyelin phosphodiesterase 3 as a novel host factor inhibiting hepatitis B virus transcription. [PDF]
Virol Sin• SMPD3 is identified as a novel host factor that inhibits Hepatitis B virus (HBV) replication at the transcriptional level. • SMPD3 knockdown enhances HBV replication in various cell models, increasing levels of HBsAg, HBeAg, and HBV DNA. • Mechanistic studies reveal SMPD3's inhibition of HBV transcription without affecting RNA stability or promoter ...
Li C +6 more
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Secretion of small/microRNAs including miR-638 into extracellular spaces by sphingomyelin phosphodiesterase 3. [PDF]
Oncol Rep, 2015 A recent study demonstrated that intracellular small/microRNAs are released from cells, and some of these extracellular RNAs are embedded in vesicles, such as ceramide-rich exosomes, on lipid-bilayer membranes. In the present study, we examined the effects of sphingomyelin phosphodiesterase 3 (SMPD3), which generates ceramide from sphingomyelin, on the
Kubota S +4 more
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eLife, 2021 Sphingolipids are important structural components of cell membranes and prominent signaling molecules controlling cell growth, differentiation, and apoptosis.
Wei Fan +9 more
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Frontiers in Genetics, 2022 The SMPD4 gene encodes sphingomyelin phosphodiesterase 4, which preferentially hydrolyzes sphingomyelin over other phospholipids. The biallelic loss-of-function variants of SMPD4 have been identified in a group of children with neurodevelopmental ...
Weigang Ji +5 more
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Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response. [PDF]
Oncotarget, 2020 Neutral sphingomyelinase 2 (nSMase2), the product of the sphingomyelin phosphodiesterase 3 (SMPD3) gene, catalyzes the hydrolysis of sphingomyelin to ceramide. Ceramide acts on various signaling pathways to influence cell proliferation, survival, and stress response.
Jabalee J +4 more
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Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug
Cell Reports, 2021 Summary: The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the blood-brain barrier renders potentially druggable amplified or mutated oncoproteins relatively inaccessible.
Junfeng Bi +24 more
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Sphingomyelin and Medullary Sponge Kidney Disease: A Biological Link Identified by Omics Approach
Frontiers in Medicine, 2021 Background: Molecular biology has recently added new insights into the comprehension of the physiopathology of the medullary sponge kidney disease (MSK), a rare kidney malformation featuring nephrocalcinosis and recurrent renal stones.
Simona Granata +10 more
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Four Novel p.N385K, p.V36A, c.1033–1034insT and c.1417–1418delCT Mutations in the Sphingomyelin Phosphodiesterase 1 (SMPD1) Gene in Patients with Types A and B Niemann-Pick Disease (NPD) [PDF]
International Journal of Molecular Sciences, 2015 Behnam Kamalidehghan, Fatemeh Keshavarzi
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Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels
Cell Reports, 2020 Summary: Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines.
Jian Shi +10 more
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