Results 31 to 40 of about 7,161 (190)

Genomic Correlates of Disease Recovery in Natural Populations of the Sierra Nevada Yellow-Legged Frog (Rana sierrae). [PDF]

Mol Ecol
ABSTRACT In our rapidly changing world, evolution is likely to play an important role in facilitating the resilience of wildlife populations. The Sierra Nevada yellow‐legged frog (Rana sierrae) provides a rare example of recovery following severe declines caused by the amphibian chytrid fungus (Batrachochytrium dendrobatidis).
Byrne AQ, Rothstein AP, Knapp RA, Rosenblum EB.   +3 more
europepmc   +2 more sources

Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels

Cell Reports, 2020
Summary: Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines.
Jian Shi, Adam J. Hyman, Dario De Vecchis, Jiehan Chong, Laeticia Lichtenstein, T. Simon Futers, Myriam Rouahi, Anne Negre Salvayre, Nathalie Auge, Antreas C. Kalli, David J. Beech   +10 more
doaj   +1 more source

Ceramide-Induced Lysosomal Biogenesis and Exocytosis in Early-Onset Preeclampsia Promotes Exosomal Release of SMPD1 Causing Endothelial Dysfunction

Frontiers in Cell and Developmental Biology, 2021
Aberrant ceramide build-up in preeclampsia, a serious disorder of pregnancy, causes exuberant autophagy-mediated trophoblast cell death. The significance of ceramide accumulation for lysosomal biogenesis in preeclampsia is unknown.
Leonardo Ermini, Abby Farrell, Abby Farrell, Sruthi Alahari, Jonathan Ausman, Jonathan Ausman, Chanho Park, Chanho Park, Julien Sallais, Megan Melland-Smith, Tyler Porter, Michael Edson, Ori Nevo, Michael Litvack, Martin Post, Martin Post, Martin Post, Isabella Caniggia, Isabella Caniggia, Isabella Caniggia, Isabella Caniggia   +20 more
doaj   +1 more source

Alternative splicing of SMPD1 in human sepsis. [PDF]

PLoS ONE, 2015
Acid sphingomyelinase (ASM or sphingomyelin phosphodiesterase, SMPD) activity engages a critical role for regulation of immune response and development of organ failure in critically ill patients.
Marcel Kramer, Stefanie Quickert, Christoph Sponholz, Uwe Menzel, Klaus Huse, Matthias Platzer, Michael Bauer, Ralf A Claus   +7 more
doaj   +1 more source

Four novel p.N385K, p.V36A, c.1033-1034insT and c.1417-1418delCT mutations in the sphingomyelin Phosphodiesterase 1 (SMPD1) gene in patients with types A and B Niemann-Pick disease (NPD). [PDF]

Int J Mol Sci, 2015
Manshadi MD, Kamalidehghan B, Keshavarzi F, Aryani O, Dadgar S, Arastehkani A, Tondar M, Ahmadipour F, Meng GY, Houshmand M.   +9 more
europepmc   +2 more sources

Porcine reproductive and respiratory syndrome virus upregulates SMPDL3B to promote viral replication by modulating lipid metabolism

iScience, 2023
Summary: Porcine reproductive and respiratory syndrome virus (PRRSV) poses a severe threat to the health of pigs globally. Host factors play a critical role in PRRSV replication.
Huan-Huan Shen, Qin Zhao, Yi-Ping Wen, Rui Wu, Sen-Yan Du, Xiao-Bo Huang, Xin-Tian Wen, San-Jie Cao, Lei Zeng, Qi-Gui Yan   +9 more
doaj   +1 more source

Evolutionary diversity of sphingolipid metabolism proteins in fungi [PDF]

IMA Fungus
Fungi are adapted to survive across environments with fluctuating oxygen availability. Transition to terrestrial and parasitic lifestyles required remodeling of the cell membrane, including sphingolipid composition. Ceramides occupy a central position in
Magdalena Płecha, Blanka Sokołowska, Drishtee Barua, Julia Bartczak, Maria Sobczyk, Dagmara Koperska, Anna Kułakowska, Adam Komosa, Anna Muszewska   +8 more
doaj   +3 more sources

Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro[S]

Journal of Lipid Research, 2020
Inhibition of acid sphingomyelinase (ASM), a lysosomal enzyme that catalyzes the hydrolysis of sphingomyelin into ceramide and phosphorylcholine, may serve as an investigational tool or a therapeutic intervention to control many diseases.
Eyad Naser, Stephanie Kadow, Fabian Schumacher, Zainelabdeen H. Mohamed, Christian Kappe, Gabriele Hessler, Barbara Pollmeier, Burkhard Kleuser, Christoph Arenz, Katrin Anne Becker, Erich Gulbins, Alexander Carpinteiro   +11 more
doaj   +1 more source

Case report: The spectrum of SMPD1 pathogenic variants in Hungary

Frontiers in Genetics, 2023
Acid sphingomyelinase deficiency (ASMD) is an autosomal recessive disease caused by biallelic pathogenic variants in the sphingomyelin phosphodiesterase-1 (SMPD1) gene.
Maria Judit Molnar, Maria Judit Molnar, Tamas Szlepak, Tamas Szlepak, Ildikó Csürke, Szendile Loth, Rita Káposzta, Melinda Erdős, Antal Dezsőfi   +8 more
doaj   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +15 more sources