Results 41 to 50 of about 36,200 (174)

Structural Basis of the Sphingomyelin Phosphodiesterase Activity in Neutral Sphingomyelinase from Bacillus cereus [PDF]

Journal of Biological Chemistry, 2006
Sphingomyelinase (SMase) from Bacillus cereus (Bc-SMase) hydrolyzes sphingomyelin to phosphocholine and ceramide in a divalent metal ion-dependent manner. Bc-SMase is a homologue of mammalian neutral SMase (nSMase) and mimics the actions of the endogenous mammalian nSMase in causing differentiation, development, aging, and apoptosis.
Hideo, Ago, Masataka, Oda, Masaya, Takahashi, Hideaki, Tsuge, Sadayuki, Ochi, Nobuhiko, Katunuma, Masashi, Miyano, Jun, Sakurai   +7 more
openaire   +2 more sources

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels [PDF]

, 2007
Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and related severe psychiatric conditions. DISC1 is a multifunctional scaffold protein that is able to interact with several proteins, including the independently ...
Millar, J.K., Mackie, S., Houslay, M. D., Porteous, D.J., Hill, E. V., Hill, E.V., Porteous, D. J., Bolger, G.B., Murdoch, H., Klussmann, E., Collins, D. M., Millar, J. K., Bolger, G. B., Houslay, M.D., Collins, D.M.   +14 more
core   +1 more source

Formation and dimerization of the phosphodiesterase active site of the Pseudomonas aeruginosa MorA, a bi-functional c-di-GMP regulator [PDF]

, 2014
Diguanylate cyclases (DGC) and phosphodiesterases (PDE) respectively synthesise and hydrolyse the secondary messenger cyclic dimeric GMP (c-di-GMP), and both activities are often found in a single protein.
Mikolajek, Halina, Keevil, Charles William, Schlaefli, Henry George, Webb, Jeremy Stephen, Tews, Ivo, Phippen, Curtis William   +5 more
core   +1 more source

SMPDL3b modulates insulin receptor signaling in diabetic kidney disease

Nature Communications, 2019
Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme known to affect membrane lipid composition. Here, Mitrofanova et al. show that increased expression of SMPDL3b in diabetes impairs insulin signaling and ceramide-1-phosphate ...
A. Mitrofanova, S. K. Mallela, G. M. Ducasa, T. H. Yoo, E. Rosenfeld-Gur, I. D. Zelnik, J. Molina, J. Varona Santos, M. Ge, A. Sloan, J. J. Kim, C. Pedigo, J. Bryn, I. Volosenco, C. Faul, Y. H. Zeidan, C. Garcia Hernandez, A. J. Mendez, I. Leibiger, G. W. Burke, A. H. Futerman, L. Barisoni, Y. Ishimoto, R. Inagi, S. Merscher, A. Fornoni   +25 more
doaj   +1 more source

Abnormalities of Sphingolipids Metabolic Pathways in the Pathogenesis of Psoriasis

Metabolites, 2023
Psoriasis is immune-mediated skin disorder affecting thousands of people. Sphingolipids (SLs) are bioactive molecules present in the epidermis, involved in the following cellular processes: proliferation, differentiation, and apoptosis of keratinocytes ...
Beatriz Burger, Roberta Nicolli Sagiorato, Isabella Cavenaghi, Hosana Gomes Rodrigues   +3 more
doaj   +1 more source

Nucleic Acids as Emerging Regulators of Calcium Phosphate Biomineralization. [PDF]

FASEB J
Calcium phosphate biomineralization has traditionally been considered a protein‐regulated process. This review highlights the emerging role of nucleic acids, which interact with mineral phases through adsorption, coprecipitation, and templating, thereby influencing crystal nucleation and growth.
Duhalde F, Landoulsi J, Houard X.
europepmc   +2 more sources

Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure [PDF]

, 2012
Contains fulltext : 107961.pdf (Publisher’s version ) (Open Access)Inflammation enhances the secretion of sphingomyelinases (SMases). SMases catalyze the hydrolysis of sphingomyelin into phosphocholine and ceramide.
Dinkla, S., Brock, R.E., Dinkla, S, Cluitmans, JC, Fuchs, B, Joosten, I, Fransen, J., Tomelleri, C, Verdurmen, W.P.R., Bosman, G.J.C.G.M., Wessels, K, Schiller, J., Wessels, K., Brock, R, Fuchs, B., Verdurmen, WP, Joosten, I., Bosman, GJ, Cluitmans, J.C.A., Schiller, J, Tomelleri, C., Fransen, J   +21 more
core   +2 more sources

Phosphodiesterase-5 inhibition mimics intermittent reoxygenation and improves cardioprotection in the hypoxic myocardium.

, 2011
UNLABELLED: Although chronic hypoxia is a claimed myocardial risk factor reducing tolerance to ischemia/reperfusion (I/R), intermittent reoxygenation has beneficial effects and enhances heart tolerance to I/R.
G Vassalli (7811732), V Rochemont (7811729), M Samaja (7811741), AF Corno (7718612), P Bianciardi (7811726), G Milano (7811723), LKV Segesser (7811735), M Guazzi (7811738)   +7 more
core   +6 more sources

Molecular genetic characterization of novel sphingomyelin phosphodiesterase 1 mutations causing niemann-pick disease. [PDF]

JIMD Rep, 2012
Niemann-Pick disease (NPD) types A and B are autosomal recessive disorders caused by acid sphingomyelinase (ASM) deficiency due to mutation in the sphingomyelin phosphodiesterase 1 gene (SMPD1). Although a number of SMPD1 mutations were reported, expression studies were performed for only a small number of missense mutations.
Tóth B, Erdős M, Székely A, Ritli L, Bagossi P, Sümegi J, Maródi L.   +6 more
europepmc   +4 more sources

The essential neutral sphingomyelinase is involved in the trafficking of the variant surface glycoprotein in the bloodstream form of Trypanosoma brucei [PDF]

, 2010
Sphingomyelin is the main sphingolipid in Trypanosoma brucei, the causative agent of African sleeping sickness. In vitro and in vivo characterization of the T.
Smith, Terry K., Young, Simon A., Young, Simon Alan   +2 more
core   +1 more source