Results 41 to 50 of about 7,161 (190)

The nSMase2/Smpd3 gene modulates the severity of muscular dystrophy and the emotional stress response in mdx mice

BMC Medicine, 2020
Background Duchenne muscular dystrophy (DMD) is a progressive, degenerative muscular disorder and cognitive dysfunction caused by mutations in the dystrophin gene.
Yasunari Matsuzaka, Jun Tanihata, Yoshiko Ooshima, Daisuke Yamada, Masayuki Sekiguchi, Shouta Miyatake, Yoshitsugu Aoki, Mika Terumitsu, Ryu Yashiro, Hirofumi Komaki, Akihiko Ishiyama, Yasushi Oya, Yukiko U. Inoue, Takayoshi Inoue, Shin’ichi Takeda, Kazuo Hashido   +15 more
doaj   +1 more source

Computational identification and experimental characterization of substrate binding determinants of nucleotide pyrophosphatase/phosphodiesterase 7 [PDF]

, 2011
Background: Nucleotide pyrophosphatase/phosphodiesterase 7 (NPP7) is the only member of the mammalian NPP enzyme family that has been confirmed to act as a sphingomyelinase, hydrolyzing sphingomyelin (SM) to form phosphocholine and ceramide.
Abby L Parrill, Daniel L Baker, Irene W Wanjala, Truc Pham   +3 more
core   +2 more sources

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation. [PDF]

Adv Sci (Weinh)
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Jia J, Gan Y, Li J, Li L, Meng H, Sun M, Ye L, Mao R, Cao X, Xia S, Bao X, Liu R, Zhang M, Xu Y.   +13 more
europepmc   +2 more sources

The LRRK2-macroautophagy axis and its relevance to Parkinson's Disease [PDF]

, 2017
A wide variety of different functions and an impressive array of interactors have been associated with leucine-rich repeat kinase 2 (LRRK2) over the years. Here, I discuss the hypothesis that LRRK2 may be capable of interacting with different proteins at
Agalliu, Alegre-Abarrategui, Alvarez-Erviti, Bang, Beilina, Bento, Bravo-San Pedro, Burchell, Burré, Claudia Manzoni, Corti, Cuervo, Dinter, Drouet, Du, Ebrahimi-Fakhari, Friedman, Gan-Or, George, Gómez-Suaga, Haack, Han, Henry, Hernandez, Kirkegaard, Lewis, Liu, Magalhaes, Manzoni, Manzoni, Manzoni, Manzoni, Matsui, Moehle, Nalls, Orenstein, Paisán-Ruíz, Park, Perrotta, Plowey, Polymeropoulos, Ramonet, Saez-Atienzar, Saez-Atienzar, Schapansky, Schapira, Singleton, Soukup, Su, Sánchez-Danés, Tang, Tong, Wallings, Wang, Zavodszky, Zimprich   +55 more
core   +1 more source

Abnormalities of Sphingolipids Metabolic Pathways in the Pathogenesis of Psoriasis

Metabolites, 2023
Psoriasis is immune-mediated skin disorder affecting thousands of people. Sphingolipids (SLs) are bioactive molecules present in the epidermis, involved in the following cellular processes: proliferation, differentiation, and apoptosis of keratinocytes ...
Beatriz Burger, Roberta Nicolli Sagiorato, Isabella Cavenaghi, Hosana Gomes Rodrigues   +3 more
doaj   +1 more source

STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection. [PDF]

, 2013
UnlabelledSTING (stimulator of interferon [IFN] genes) initiates type I IFN responses in mammalian cells through the detection of microbial nucleic acids. The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-dependent
Barker, Jeffrey R, Burdette, Dara L, Carpenter, Victoria K, Koestler, Benjamin J, Valdivia, Raphael H, Vance, Russell E, Waters, Christopher M   +6 more
core   +2 more sources

SMPDL3b modulates insulin receptor signaling in diabetic kidney disease

Nature Communications, 2019
Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme known to affect membrane lipid composition. Here, Mitrofanova et al. show that increased expression of SMPDL3b in diabetes impairs insulin signaling and ceramide-1-phosphate ...
A. Mitrofanova, S. K. Mallela, G. M. Ducasa, T. H. Yoo, E. Rosenfeld-Gur, I. D. Zelnik, J. Molina, J. Varona Santos, M. Ge, A. Sloan, J. J. Kim, C. Pedigo, J. Bryn, I. Volosenco, C. Faul, Y. H. Zeidan, C. Garcia Hernandez, A. J. Mendez, I. Leibiger, G. W. Burke, A. H. Futerman, L. Barisoni, Y. Ishimoto, R. Inagi, S. Merscher, A. Fornoni   +25 more
doaj   +1 more source

Manganese is essential for PlcP metallophosphoesterase activity involved in lipid 2 remodelling in abundant marine heterotrophic bacteria [PDF]

, 2018
In vast areas of the ocean, microbes must adapt to the availability of scarce nutrients, and a key strategy for reducing the cellular phosphorus (P) quota is to remodel membranes by replacing phospholipids with non-P surrogate lipids.
Chen, Yin, Quareshy, Mussa, Scanlan, David J., Wei, Tao, Zhang, Yu-zhong   +4 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2015/16:Enzymes [PDF]

, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
Aldrich, R, Alexander, SPH, Attali, B, Back, M, Barnes, NM, Bathgate, R, Beart, PM, Becirovic, E, Benson, HE, Biel, M, Birdsall, NJ, Boison, D, Brauner-Osborne, H, Broeer, S, Bryant, C, Burnstock, G, Burris, T, Cain, D, Calo, G, Chan, SL, Chandy, KG, Chiang, N, Christakos, S, Christopoulos, A, Chun, JJ, Chung, J-J, Clapham, DE, Connor, MA, Coons, L, Cox, HM, Dautzenberg, FM, Davies, JA, Dent, G, Douglas, SD, Dubocovich, ML, Edwards, DP, Fabbro, D, Faccenda, E, Farndale, R, Fong, TM, Forrest, D, Fowler, CJ, Fuller, P, Gainetdinov, RR, Gershengorn, MA, Goldin, A, Goldstein, SAN, Grimm, SL, Grissmer, S, Gundlach, AL, Hagenbuch, B, Hammond, JR, Hancox, JC, Hartig, S, Hauger, RL, Hay, DL, Hebert, T, Hollenberg, AN, Holliday, ND, Hoyer, D, Ijzerman, AP, Inui, KI, Ishii, S, Jacobson, KA, Jan, LY, Jarvis, GE, Jensen, R, Jetten, A, Jockers, R, Kaczmarek, LK, Kanai, Y, Kang, HS, Karnik, S, Kelly, E, Kerr, ID, Korach, KS, Lange, CA, Larhammar, D, Leeb-Lundberg, F, Leurs, R, Lolait, SJ, Macewan, D, Maguire, JJ, Marrion, N, May, JM, Mazella, J, McArdle, CA, McDonnell, DP, Michel, MC, Miller, LJ, Mitolo, V, Monie, T, Monk, PN, Mouillac, B, Murphy, PM, Nahon, J-L, Nerbonne, J, Nichols, CG, Norel, X, Oakley, R, Offermanns, S, Palmer, LG, Panaro, MA, Pawson, AJ, Perez-Reyes, E, Pertwee, RG, Peters, JA, Pike, JW, Pin, JP, Pintor, S, Plant, LD, Poyner, DR, Prossnitz, ER, Pyne, S, Ren, D, Richer, JK, Rondard, P, Ross, RA, Sackin, H, Safi, R, Sanguinetti, MC, Sartorius, CA, Segaloff, DL, Sharman, JL, Sladek, FM, Southan, C, Stewart, G, Stoddart, LA, Striessnig, J, Summers, RJ, Takeda, Y, Tetel, M, Toll, L, Trimmer, JS, Tsai, M-J, Tsai, SY, Tucker, S, Usdin, TB, Vilargada, J-P, Vore, M, Ward, DT, Waxman, SG, Webb, P, Wei, AD, Weigel, N, Willars, GB, Winrow, C, Wong, SS, Wulff, H, Ye, RD, Young, M, Zajac, J-M   +151 more
core   +4 more sources

Mammalian cryptochromes impinge on cell cycle progression in a circadian clock-independent manner [PDF]

, 2011
By gating cell cycle progression to specific times of the day, the intracellular circadian clock is thought to reduce the exposure of replicating cells to potentially hazardous environmental and endogenous genotoxic compounds.
Destici Eugin, Oklejewicz Małgorzata, Saito Shoko, van der Horst Gijsbertus T.J., 齋藤 祥子   +4 more
core   +1 more source