Results 51 to 60 of about 7,161 (190)

Structural Basis of the Sphingomyelin Phosphodiesterase Activity in Neutral Sphingomyelinase from Bacillus cereus [PDF]

Journal of Biological Chemistry, 2006
Sphingomyelinase (SMase) from Bacillus cereus (Bc-SMase) hydrolyzes sphingomyelin to phosphocholine and ceramide in a divalent metal ion-dependent manner. Bc-SMase is a homologue of mammalian neutral SMase (nSMase) and mimics the actions of the endogenous mammalian nSMase in causing differentiation, development, aging, and apoptosis.
Hideo, Ago, Masataka, Oda, Masaya, Takahashi, Hideaki, Tsuge, Sadayuki, Ochi, Nobuhiko, Katunuma, Masashi, Miyano, Jun, Sakurai   +7 more
openaire   +2 more sources

Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure. [PDF]

, 2012
Inflammation enhances the secretion of sphingomyelinases (SMases). SMases catalyze the hydrolysis of sphingomyelin into phosphocholine and ceramide.
Bosman, GJ, Brock, R, Cluitmans, JC, Dinkla, S, Fransen, J, Fuchs, B, Joosten, I, Schiller, J, Tomelleri, C, Verdurmen, WP, Wessels, K   +10 more
core   +1 more source

Myocyte enhancer factor 2C: an osteoblast transcription factor identified by DMSO enhanced mineralization [PDF]

, 2011
Free to read on publisher website Rapid mineralization of cultured osteoblasts could be a useful characteristic in stem-cell mediated therapies for fracture and other orthopaedic problems. Dimethyl sulfoxide (DMSO) is a small amphipathic solvent molecule
Bacic-Welsh, Desa, Hobbs, Carl, Hutmacher, Dietmar, Morrison, Nigel, Stephens, Alexandre, Stephens, Sebastien, Woodruff, Mia   +6 more
core   +2 more sources

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets [PDF]

, 2015
The connection between inflammation and tumourigenesis has been well established. However, the detailed molecular mechanism underlying inflammation-associated tumourigenesis remains unknown because this process involves a complex interplay between immune
Chen, Limin, Geng, Meiyu, Huang, Ming, Jiang, Hualiang, Liang, Zhongjie, Liu, Hong, Lu, Junyan, Luo, Cheng, Shen, Bairong, Spiegel, Sarah, Zeng, Hanlin, Zhang, Hao, Zhang, Liyi   +12 more
core   +2 more sources

CodY, a pleiotropic regulator, influences multicellular behaviour and efficient production of virulence factors in Bacillus cereus [PDF]

, 2012
In response to nutrient limitation in the environment, the global transcriptional regulator CodY modulates various pathways in low G+C Gram-positive bacteria.
Basset, Coraline, Granum, Per Einar, Kovacs, Akos T., Kuipers, Oscar P., Lindback, Toril, Lindbäck, Toril, Mols, Maarten   +6 more
core   +3 more sources

Determination of 7-ketocholesterol in plasma by LC-MS for rapid diagnosis of acid SMase-deficient Niemann-Pick disease

Journal of Lipid Research, 2014
Acid sphingomyelinase (ASMase)-deficient Niemann-Pick disease (NPD) is caused by mutations in the sphingomyelin phosphodiesterase 1 (SMPD1) gene, resulting in accumulation of sphingomyelin in the lysosomes and secondary changes in cholesterol metabolism.
Na Lin, Huiwen Zhang, Wenjuan Qiu, Jun Ye, Lianshu Han, Yu Wang, Xuefan Gu   +6 more
doaj   +1 more source

The landscape of acid sphingomyelinase deficiency in a new therapeutic era: insights from experts in the Gulf region

Journal of Biochemical and Clinical Genetics, 2023
Acid sphingomyelinase deficiency (ASMD) is an autosomal-recessive progressive multiorgan metabolic disorder due to pathogenic variants in the sphingomyelin phosphodiesterase 1 gene.
Moeenaldeen AlSayed, Fatma Al-Jasmi, Tawfeg Ben Omran, Fathiya Al-Murshedi, Rawda Sunbul, Nadia Al-Hashmi, Talal Al-Enazi   +6 more
doaj   +1 more source

Niemann-Pick disease type-B: a unique case report with compound heterozygosity and complicated lipid management

BMC Medical Genetics, 2020
Background Niemann-Pick disease (NPD) is a rare autosomal recessive hereditary disease characterized by deficient activity of acid sphingomyelinase.
L. Ordieres-Ortega, F. Galeano-Valle, M. Mallén-Pérez, C. Muñoz-Delgado, J. E. Apaza-Chavez, F. J. Menárguez-Palanca, L. A. Alvarez-Sala Walther, P. Demelo-Rodríguez   +7 more
doaj   +1 more source

Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide. [PDF]

PLoS ONE, 2014
Acid sphingomyelinase (aSMase) is a human enzyme that catalyzes the hydrolysis of sphingomyelin to generate the bioactive lipid ceramide and phosphocholine.
Michael V Airola, Jessica M Tumolo, Justin Snider, Yusuf A Hannun   +3 more
doaj   +1 more source

TGFβ/BMP immune signaling affects abundance and function of C. elegans gut commensals. [PDF]

, 2019
The gut microbiota contributes to host health and fitness, and imbalances in its composition are associated with pathology. However, what shapes microbiota composition is not clear, in particular the role of genetic factors.
Berg, Maureen, Cho, Juhyun, Crits-Christoph, Alex, Monnin, David, Nelson, Lydia, Shapira, Michael   +5 more
core   +2 more sources