Results 71 to 80 of about 36,200 (174)

SMPDL3B Predicts Poor Prognosis and Contributes to Development of Acute Myeloid Leukemia

Frontiers in Molecular Biosciences, 2021
Background: Acute myeloid leukemia (AML), characterized by the low cure rate and high relapse, urgently needs novel diagnostic or prognostic biomarkers and potential therapeutic targets.
Huiqing Qu, Ye Zhu
doaj   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, Volume 58, Issue 5, Page 1396-1412, September 2026.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Sildenafil Citrate-Restored eNOS and PDE5 Regulation in Sickle Cell Mouse Penis Prevents Priapism Via Control of Oxidative/Nitrosative Stress [PDF]

, 2013
Sildenafil citrate revolutionized the practice of sexual medicine upon its federal regulatory agency approval approximately 15 years ago as the prototypical phosphodiesterase type 5 inhibitor indicated for the treatment of male erectile dysfunction.
Berkowitz, Dan E, Biljana Musicki, Trinity J Bivalacqua, Musicki Biljana, Berkowitz, DE, Bivalacqua, TJ, Lewis L Hsu, Biljana Musicki (429541), Burnett, Arthur L, Hunter C Champion, Lewis L. Hsu (7926017), Dan E. Berkowitz (7926020), Arthur L. Burnett (7926023), Trinity J. Bivalacqua (7926014), Champion Hunter C., Musicki, Biljana, Burnett Arthur L., Hsu, LL, Hsu Lewis L., Hunter C. Champion (6834875), Bivalacqua Trinity J., Champion, HC, Arthur L Burnett, Hsu, Lewis L, Dan E Berkowitz, Burnett, AL, Champion, Hunter C, Bivalacqua, Trinity J, Berkowitz Dan E., Musicki, B   +29 more
core   +2 more sources

Cloning of SMPD in Racomitrium canescens and analysis of its responses to drought and high-temperature stress

Guangxi Zhiwu
Sphingomyelin phosphodiesterase(SMPD)plays a crucial role in the sphingolipid metabolism process by hydrolyzing sphingomyelin into phosphatidylcholines and ceramides.
BAO Wei, WANG Jingjing, SHA Wei, ZHANG Meijuan, PENG Yifang, MA Tianyi*
doaj   +1 more source

Increased liver tumor formation in neutral sphingomyelinase-2-deficient mice

Journal of Lipid Research, 2018
Sphingolipids are key signaling lipids in cancer. Genome-wide studies have identified neutral SMase-2 (nSMase2), an enzyme generating ceramide from SM, as a potential repressor for hepatocellular carcinoma.
Liansheng Zhong, Ji Na Kong, Michael B. Dinkins, Silvia Leanhart, Zhihui Zhu, Stefka D. Spassieva, Haiyan Qin, Hsuan-Pei Lin, Ahmed Elsherbini, Rebecca Wang, Xue Jiang, Mariana Nikolova-Karakashian, Guanghu Wang, Erhard Bieberich   +13 more
doaj   +1 more source

Novel insight into the lipid network of plasma extracellular vesicles reveal sex-based differences in the lipidomic profile of alcohol use disorder patients

Biology of Sex Differences
Background Alcohol use disorder (AUD) is one of the most common psychiatric disorders, with the consumption of alcohol considered a leading cause of preventable deaths worldwide.
Carla Perpiñá-Clérigues, Susana Mellado, Cristina Galiana-Roselló, María Fernández-Regueras, Miguel Marcos, Francisco García-García, María Pascual   +6 more
doaj   +1 more source

The essential role of sphingolipids in TRPC5 ion channel localization and functionality within lipid rafts

Pharmacological Research
Sphingolipids are critical components of cellular membranes that play a pivotal role in modulating ion channel function by forming lipid rafts that stabilize and localize these channels.
Junliang Wan, Zhenying Hu, Huaiyi Zhu, Jingyi Li, Ziyuan Zheng, Zhitao Deng, Junyan Lu, Yu Chen, Gui-Lan Chen, Bo Zeng, Jin Zhang, Jingjing Duan   +11 more
doaj   +1 more source

Podocyte Pathology and Nephropathy

Frontiers in Endocrinology, 2014
Sphingolipids are components of the lipid rafts in plasma membranes, which are important for proper function of podocytes, a key element of the glomerular filtration barrier.
Sandra eMerscher, Sandra eMerscher, Alessia eFornoni, Alessia eFornoni   +3 more
doaj   +1 more source

Evaluation of CEP55, SERPINE1 and SMPD3 genes and proteins as diagnostic and prognostic biomarkers in gastric carcinoma in Egyptian patients

Beni-Suef University Journal of Basic and Applied Sciences, 2022
Background Gastric carcinoma (GC) is a fatal disease. Detection of new biomarkers that can be utilized in the early diagnosis of GC is a pressing need.
Marwa Sayed Abdel-Tawab, Hanan Fouad, Ahmed Yahiya, Ahmed Abd-Eltawab Tammam, Alzhraa M. Fahmy, Saeed Shaaban, Soha Mahmoud Abdel-Salam, Naglaa Adly Abd Elazeem   +7 more
doaj   +1 more source

Sphingomyelin metabolites inhibit sphingomyelin synthase and CTP:phosphocholine cytidylyltransferase

, 2001
Tissue injury in inflammation involves the release of several cytokines that activate sphingomyelinases and generate ceramide. In the lung, the impaired metabolism of surfactant phosphatidylcholine (PC) accompanies this acute and chronic injury.
Dolphin Smith, Jeevalatha Vivekananda, Richard J. King   +2 more
core   +1 more source