Results 71 to 80 of about 7,161 (190)

Vergleich dreier Ringversuche zur radioimmunologischen Thyrotropin-Bestimmung nach dem "Münchner Modell" [PDF]

, 1983
Peer ...
Habermann, J., König, A., Marschner, I., Scriba, Peter Christian, van Thiel, D., Wood, W. G.   +5 more
core   +2 more sources

TcALS knockdown accelerates metamorphosis via insulin signaling in Tribolium castaneum

Insect Science, EarlyView.
RNAi silencing of TcALS accelerates larva‐to‐pupa metamorphosis in Tribolium castaneum. Abstract Insect metamorphosis is an evolutionary adaptation precisely regulated by nutritional and hormonal cues. The red flour beetle Tribolium castaneum, a major stored‐product pest, serves as an excellent model for studying this process.
Min Li, Jie Chen, Zi‐Ye Wang, Fei‐Feng Wang, Lu‐Lu Dong, Jun Pan, Min‐Er Li, Lin Yu, Wen Sang   +8 more
wiley   +1 more source

SMPDL3B Predicts Poor Prognosis and Contributes to Development of Acute Myeloid Leukemia

Frontiers in Molecular Biosciences, 2021
Background: Acute myeloid leukemia (AML), characterized by the low cure rate and high relapse, urgently needs novel diagnostic or prognostic biomarkers and potential therapeutic targets.
Huiqing Qu, Ye Zhu
doaj   +1 more source

Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment. [PDF]

, 2015
Nowadays we understand cell membranes not as a simple double lipid layer but as a collection of complex and dynamic protein-lipid structures and microdomains that serve as functional platforms for interacting signaling lipids and proteins.
Balogh, Gábor, Busquets, Xavier, Escribá, Pablo V., Harwood, John L., Horváth, Ibolya, Inokuchi, Jin-ichi, Török, Zsolt, Vígh, László   +7 more
core   +1 more source

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1494-1502, June 2026.
Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz, Eric Farber‐Eger, Marwa Tantawy, Neyousha Shahisavandi, Timothy J. Garrett, Samuel M. Rubinstein, Michael G. Fradley, Mohammed E. Alomar, Danny DeAvila, Kenneth H Shain, R. Frank Cornell, Daniel Lenihan, Qing Lu, Quinn S Wells, Rachid C. Baz, Yan Gong   +15 more
wiley   +1 more source

Aberrant lipid metabolism: an emerging diagnostic and therapeutic target in ovarian cancer [PDF]

, 2013
Ovarian cancer remains the most lethal gynaecological cancer. A better understanding of the molecular pathogenesis of ovarian cancer is of critical importance to develop early detection tests and identify new therapeutic targets that would increase ...
Agarwal, Anliker, Aoki, Baker, Bensaad, Cai, Carmela Ricciardelli, Carmen Pyragius, Chae, Chajes, Chang, Choi, Daly, Dong, Eck, Eder, Fishman, Gansler, Gatt, Hanada, Hu, Hu, Illuzzi, Imamura, Iwasawa, Jeong, Jiang, Kimura, Kushi, La Vecchia, Lee, Lee, Li, Little, Makhlouf, Maria Fuller, Martin Oehler, Menendez, Migita, Mukherjee, Murthi, Nakamura, Nam, Nam, Nieman, Noguchi, Pan, Pewzner-Jung, Pizer, Ptaszynska, Pustilnik, Radin, Rahman, Ren, Risch, Risch, Ryland, Sawada, Selzner, Shida, Shintani, Siegel, Song, Spiegel, Sutphen, Swanton, Swinnen, Swinnen, Tania, Tokumura, Tomek, Ueda, Umezu-Goto, Van Vlerken, Vidot, Von Haefen, Wang, Watanabe, Xiao, Xu, Xu, Yanagida, Yang, Yu, Zhang, Zhou, Zhou   +86 more
core   +3 more sources

The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao, Yuheng Qin, Haoyu Wan, Guang Lu, Han‐Ming Shen   +4 more
wiley   +1 more source

Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response

Journal of Lipid Research, 2013
Plasma secretion of acid sphingomyelinase is a hallmark of cellular stress response resulting in the formation of membrane embedded ceramide-enriched lipid rafts and the reorganization of receptor complexes.
Nayla Jbeily, Iris Suckert, Falk A. Gonnert, Benedikt Acht, Clemens L. Bockmeyer, Sascha D. Grossmann, Markus F. Blaess, Anja Lueth, Hans-Peter Deigner, Michael Bauer, Ralf A. Claus   +10 more
doaj   +1 more source

Community proteogenomics reveals the systemic impact of phosphorus availability on microbial functions in tropical soil. [PDF]

, 2018
Phosphorus is a scarce nutrient in many tropical ecosystems, yet how soil microbial communities cope with growth-limiting phosphorus deficiency at the gene and protein levels remains unknown.
Guo, Xuan, Hazen, Terry C, Li, Zhou, Mayes, Melanie A, Pan, Chongle, Paša-Tolić, Ljiljana, Song, Yang, Tfaily, Malak M, Tringe, Susannah G, Turner, Benjamin L, Wright, S Joseph, Yao, Qiuming   +11 more
core   +1 more source

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2‐skewed immune polarization

The Journal of Pathology, Volume 269, Issue 2, Page 232-247, June 2026.
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Mariko Takada, Miho Sashikawa‐Kimura, Yusuke Ohno, Md Razib Hossain, Xiaonan Xie, Kazuhisa Iwabuchi, Mayumi Komine, Mamitaro Ohtsuki, Genji Imokawa   +8 more
wiley   +1 more source