Results 71 to 80 of about 4,601 (147)

Identification of ceRNA Regulatory Networks Driven by the lncRNA NEAT1 in Multiple Myeloma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT The lncRNA NEAT1 is overexpressed in multiple myeloma (MM) plasma cells and plays a key role in MM pathogenesis. NEAT1 is involved in ceRNA network in several cancers; however, data in MM are virtually absent. This study identified a NEAT1‐driven ceRNA network involving 96 miRNAs and 40 target genes, selected as concurrently downregulated in ...
Domenica Ronchetti, Valentina Traini, Ilaria Silvestris, Giuseppina Fabbiano, Andrea Devecchi, Federica Torricelli, Noemi Puccio, Ilaria Craparotta, Marco Bolis, Roberto Piva, Antonino Neri, Luca Agnelli, Francesco Passamonti, Niccolò Bolli, Elisa Taiana   +14 more
wiley   +1 more source

Ceramide-induced cleavage of GPR64 intracellular domain drives Ewing sarcoma

Cell Reports
Summary: Ewing sarcoma is a cancer of bone and soft tissue in children and young adults primarily driven by the EWS-FLI1 fusion oncoprotein, which has been undruggable.
Kruthi Suvarna, Panneerselvam Jayabal, Xiuye Ma, Hu Wang, Yidong Chen, Susan T. Weintraub, Xianlin Han, Peter J. Houghton, Yuzuru Shiio   +8 more
doaj   +1 more source

ESI-MS quantitation of increased sphingomyelin in Niemann-Pick disease type B HDL

Journal of Lipid Research, 2005
HDLs have been proposed to have antiatherogenic properties because of their role in reverse cholesterol transport as lipid acceptors. To elucidate the phospholipid profile of these particles, we used electrospray ionization mass spectrometry to examine ...
Ching Yin Lee, Alain Lesimple, Åsmund Larsen, Orval Mamer, Jacques Genest   +4 more
doaj   +1 more source

The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Alzheimer's disease (AD) and glioblastoma multiforme (GBM) are biologically distinct age‐related brain disorders with opposing clinical phenotypes. AD is characterised by progressive neurodegeneration and cognitive decline, whereas GBM is characterised by aggressive cellular proliferation and a poor prognosis.
Ana B. Caniceiro, Sofia P. Agostinho, Luiz F. Piochi, Nícia Rosário‐Ferreira, Irina S. Moreira   +4 more
wiley   +1 more source

Case report: Clinical, imaging, and genetic characteristics of type B niemann pick disease combined with segawa syndrome diagnosed via dual gene sequencing

Frontiers in Genetics
Niemann Pick disease B (NPB) often presents with hepatosplenomegaly and lung pathological changes, but it usually does not present with central nervous system symptoms. This report presents the unique case of a 21-year-old woman with a 10-year history of
Fang Wu, Dongying Su, Weisi Wang, Xia Song, Shufeng Fan, Jinzhan Su, Linying Ma, Jianxia Xu, Qinpan Rao   +8 more
doaj   +1 more source

The Neuroprotective Effect of Amitriptyline on Radiation-Induced Impairment of Hippocampal Neurogenesis

Dose-Response, 2019
The radioprotective effect of amitriptyline, an inhibitor of acid sphingomyelinase (ASMase), on radiation-induced impairment of hippocampal neurogenesis, loss of interneuron, and animal weight changes was investigated in BALB/c mice by immunostaining of ...
Yu Rong Guo, Zi Wei Liu, Shuang Peng, Meng Yun Duan, Jing Wei Feng, Wei Feng Wang, Yan Hua Xu, Xi Tang, Xiang Zhi Zhang, Bo Xu Ren, Feng Ru Tang   +10 more
doaj   +1 more source

Favorable clinical response to olipudase alfa in a patient with two variants of uncertain significance in SMPD1: a case report

Egyptian Journal of Medical Human Genetics
Background Acid sphingomyelinase deficiency (ASMD), also known as Niemann–Pick disease, is a rare lysosomal storage disorder caused by biallelic pathogenic variants in the Sphingomyelin phosphodiesterase 1 (SMPD1) gene, leading to the deficient activity ...
Luz María Sánchez-Sánchez, Jorge Álvarez-Longoria, Beatriz De la Fuente-Cortez, Valentina Martínez-Montoya, Ekaterina Sánchez-Romero   +4 more
doaj   +1 more source

Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer’s Disease

Drug Design, Development and Therapy, 2022
Yi-Yu Qi,1,* Xia Heng,1,* Zeng-Ying Yao,2 Shu-Yue Qu,1 Ping-Yuan Ge,1 Xin Zhao,1 Sai-jia Ni,2 Rui Guo,3 Nian-Yun Yang,1 Qi-Chun Zhang,2 Hua-Xu Zhu1 1Department of Traditional Chinese Medicine Processing and Preparation, Nanjing University of ...
Qi YY, Heng X, Yao ZY, Qu SY, Ge PY, Zhao X, Ni S, Guo R, Yang NY, Zhang QC, Zhu HX   +10 more
doaj  

Predicting the mechanism of phospholipidosis

Journal of Cheminformatics, 2012
The mechanism of phospholipidosis is still not well understood. Numerous different mechanisms have been proposed, varying from direct inhibition of the breakdown of phospholipids to the binding of a drug compound to the phospholipid, preventing breakdown.
Lowe Robert, Mussa Hamse Y, Nigsch Florian, Glen Robert C, Mitchell John BO   +4 more
doaj   +1 more source

Abstract 4161: Protecting Sphingomyelin Phosphodiesterase Acid Like 3B (SMPDL3b) enhances kidney function and reduces concurrent chemoradiotherapy-induced nephrotoxicity

Cancer Research, 2018
Abstract Background: Cisplatin is a widely used radiosensitizer. Dose-related and cumulative renal insufficiency, including acute renal failure, are the primary dose-limiting toxicities of cisplatin. The lipid-modulating enzyme sphingomyelin phosphodiesterase acid-like 3B (SMPDL3b) and Sphingosine 1-Phosphate Receptor-1 (S1P1) are ...
Anis Ahmad, Alla Mitrofanova, Saba Ansari, Junwei Shi, Yidong Yang, Sandra Merscher, Alessia Fornoni, Youssef Zeidan, Brian Marples   +8 more
openaire   +1 more source