Results 81 to 90 of about 36,200 (174)
Inhibition of acid sphingomyelinase disrupts LYNUS signaling and triggers autophagy
Journal of Lipid Research, 2018 Activation of the lysosomal ceramide-producing enzyme, acid sphingomyelinase (ASM), by various stresses is centrally involved in cell death and has been implicated in autophagy.
Matthew J. Justice +6 more
doaj +1 more source
Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 3, July/September 2026.Abstract OBJECTIVE To examine associations of inherited chromosomally integrated human herpesvirus 6 (iciHHV‐6) with incident dementia and mortality, characterize proteomic and metabolomic correlates of carrier status, and evaluate whether these biomarkers relate to dementia and mortality risk.
May A. Beydoun +10 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1494-1502, June 2026.Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz +15 more
wiley +1 more source
The sphingomyelin biosynthetic pathway.
, 2013 The precursors of sphingomyelin are synthesized in the endoplasmic reticulum with subsequent transfer of ceramide to the Golgi apparatus, the site of the final step in sphingomyelin biosynthesis.
Ling Gu (119535) +3 more
core +1 more source
Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma
eFood, Volume 7, Issue 3, June 2026.Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie +5 more
wiley +1 more source
The Role of N6‐Methyladenosine Modification in Health and Disease
MedComm, Volume 7, Issue 6, June 2026.N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li +6 more
wiley +1 more source
Journal of Lipid Research, 2006 We previously reported that human Niemann-Pick Disease type B (NPD-B) is associated with low HDL. In this study, we investigated the pathophysiology of this HDL deficiency by examining both HDL samples from NPD-B patients and nascent high density ...
Ching Yin Lee +8 more
doaj +1 more source
The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 2, June 2026.Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao +4 more
wiley +1 more source
Reverse sphingomyelin-synthase in rat liver chromatin [PDF]
, 2003 The chromatin phospholipid fraction is enriched in sphingomyelin content which changes during cell maturation and proliferation. Recently, we have demonstrated that the sphingomyelin variations can be due to chromatin neutral sphingomyelinase and ...
Magni, Mariapia Viola +5 more
core +1 more source
Scientific ReportsPrevious studies have highlighted the involvement of PM2.5 in the pathogenesis of airway hyperresponsiveness, but the precise role of exosomes in mediating intercellular communication in this context remains unclear.
Shujie Hou +5 more
doaj +1 more source