Results 81 to 90 of about 7,161 (190)

Long-term biopermanence of ceramides, cholesteryl esters, and ether-linked triglycerides with very-long-chain PUFA in the cadmium-damaged testis [PDF]

, 2014
Cadmium is known to harm rat testis by causing the dose-dependent apoptotic or necrotic death of seminiferous epithelium cells. Here we investigated how this affects the lipids with long-chain (C18-C22) and very-long-chain (C24-C32) polyunsaturated fatty
Aveldaño, Marta I., Zanetti, Samanta Romina   +1 more
core   +2 more sources

Increased liver tumor formation in neutral sphingomyelinase-2-deficient mice

Journal of Lipid Research, 2018
Sphingolipids are key signaling lipids in cancer. Genome-wide studies have identified neutral SMase-2 (nSMase2), an enzyme generating ceramide from SM, as a potential repressor for hepatocellular carcinoma.
Liansheng Zhong, Ji Na Kong, Michael B. Dinkins, Silvia Leanhart, Zhihui Zhu, Stefka D. Spassieva, Haiyan Qin, Hsuan-Pei Lin, Ahmed Elsherbini, Rebecca Wang, Xue Jiang, Mariana Nikolova-Karakashian, Guanghu Wang, Erhard Bieberich   +13 more
doaj   +1 more source

Evaluation of CEP55, SERPINE1 and SMPD3 genes and proteins as diagnostic and prognostic biomarkers in gastric carcinoma in Egyptian patients

Beni-Suef University Journal of Basic and Applied Sciences, 2022
Background Gastric carcinoma (GC) is a fatal disease. Detection of new biomarkers that can be utilized in the early diagnosis of GC is a pressing need.
Marwa Sayed Abdel-Tawab, Hanan Fouad, Ahmed Yahiya, Ahmed Abd-Eltawab Tammam, Alzhraa M. Fahmy, Saeed Shaaban, Soha Mahmoud Abdel-Salam, Naglaa Adly Abd Elazeem   +7 more
doaj   +1 more source

Differential Gene Expression in Human Hippocampus With Aging

Aging Cell, Volume 25, Issue 4, April 2026.
2 complementary analysis from a transcriptome study in human hippocampal samples of different ages revealed a set of genes differentially expressed in aged individuals linked to inflammation and immune system pathways, DNA repair (RAD23) or neural activity.
Ander Saenz‐Antoñanzas, Manuel Moreno‐Valladares, Maider Muñoz‐Culla, Sara Cruces‐Salguero, Jon Landa, Ainhoa Alberro, Jhonatan Vergara‐Arce, Marta Arroyo‐Izaga, David Otaegui, Ander Matheu   +9 more
wiley   +1 more source

Podocyte Pathology and Nephropathy

Frontiers in Endocrinology, 2014
Sphingolipids are components of the lipid rafts in plasma membranes, which are important for proper function of podocytes, a key element of the glomerular filtration barrier.
Sandra eMerscher, Sandra eMerscher, Alessia eFornoni, Alessia eFornoni   +3 more
doaj   +1 more source

Identification of ceRNA Regulatory Networks Driven by the lncRNA NEAT1 in Multiple Myeloma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT The lncRNA NEAT1 is overexpressed in multiple myeloma (MM) plasma cells and plays a key role in MM pathogenesis. NEAT1 is involved in ceRNA network in several cancers; however, data in MM are virtually absent. This study identified a NEAT1‐driven ceRNA network involving 96 miRNAs and 40 target genes, selected as concurrently downregulated in ...
Domenica Ronchetti, Valentina Traini, Ilaria Silvestris, Giuseppina Fabbiano, Andrea Devecchi, Federica Torricelli, Noemi Puccio, Ilaria Craparotta, Marco Bolis, Roberto Piva, Antonino Neri, Luca Agnelli, Francesco Passamonti, Niccolò Bolli, Elisa Taiana   +14 more
wiley   +1 more source

Cloning of SMPD in Racomitrium canescens and analysis of its responses to drought and high-temperature stress

Guangxi Zhiwu
Sphingomyelin phosphodiesterase(SMPD)plays a crucial role in the sphingolipid metabolism process by hydrolyzing sphingomyelin into phosphatidylcholines and ceramides.
BAO Wei, WANG Jingjing, SHA Wei, ZHANG Meijuan, PENG Yifang, MA Tianyi*
doaj   +1 more source

Inhibition of acid sphingomyelinase disrupts LYNUS signaling and triggers autophagy

Journal of Lipid Research, 2018
Activation of the lysosomal ceramide-producing enzyme, acid sphingomyelinase (ASM), by various stresses is centrally involved in cell death and has been implicated in autophagy.
Matthew J. Justice, Irina Bronova, Kelly S. Schweitzer, Christophe Poirier, Janice S. Blum, Evgeny V. Berdyshev, Irina Petrache   +6 more
doaj   +1 more source

The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Alzheimer's disease (AD) and glioblastoma multiforme (GBM) are biologically distinct age‐related brain disorders with opposing clinical phenotypes. AD is characterised by progressive neurodegeneration and cognitive decline, whereas GBM is characterised by aggressive cellular proliferation and a poor prognosis.
Ana B. Caniceiro, Sofia P. Agostinho, Luiz F. Piochi, Nícia Rosário‐Ferreira, Irina S. Moreira   +4 more
wiley   +1 more source

Novel insight into the lipid network of plasma extracellular vesicles reveal sex-based differences in the lipidomic profile of alcohol use disorder patients

Biology of Sex Differences
Background Alcohol use disorder (AUD) is one of the most common psychiatric disorders, with the consumption of alcohol considered a leading cause of preventable deaths worldwide.
Carla Perpiñá-Clérigues, Susana Mellado, Cristina Galiana-Roselló, María Fernández-Regueras, Miguel Marcos, Francisco García-García, María Pascual   +6 more
doaj   +1 more source