Results 101 to 110 of about 7,161 (190)

Disrupting Lipid Raft Microdomains to Block Polyploid Giant Cancer Cell Budding and Enhance Radiotherapy Response

Advanced Science, Volume 13, Issue 9, 13 February 2026.
Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng, Haoran Sun, Jin Cheng, Ruyi Zhao, Jianzhu Xie, Yanwei Song, Yucui Zhao, Chenwei Lin, Binjie Hu, Yanping Gong, Jun Lin, Sijia He, Yuntao Luo, Minghui Zhao, Yiwei Wang, Ming Jiao, Yuqin Yang, Jikun Li, Shujie Xia, Chuanyuan Li, Qian Huang   +20 more
wiley   +1 more source

Ceramide-induced cleavage of GPR64 intracellular domain drives Ewing sarcoma

Cell Reports
Summary: Ewing sarcoma is a cancer of bone and soft tissue in children and young adults primarily driven by the EWS-FLI1 fusion oncoprotein, which has been undruggable.
Kruthi Suvarna, Panneerselvam Jayabal, Xiuye Ma, Hu Wang, Yidong Chen, Susan T. Weintraub, Xianlin Han, Peter J. Houghton, Yuzuru Shiio   +8 more
doaj   +1 more source

Implications of lymphocyte anergy to glycolipids in multiple sclerosis (MS): iNKT cells may mediate the MS infectious trigger [PDF]

, 2013
Immunogenic lipids may play key roles in host defenses against infection and in generating autoimmune inflammation and organ-specific damage. In multiple sclerosis (MS) there are unequivocal autoimmune features and vulnerability to aggravation or ...
Hogan, Edward L., O’Keeffe, Joan, Podbielska, Maria   +2 more
core   +3 more sources

Case report: Clinical, imaging, and genetic characteristics of type B niemann pick disease combined with segawa syndrome diagnosed via dual gene sequencing

Frontiers in Genetics
Niemann Pick disease B (NPB) often presents with hepatosplenomegaly and lung pathological changes, but it usually does not present with central nervous system symptoms. This report presents the unique case of a 21-year-old woman with a 10-year history of
Fang Wu, Dongying Su, Weisi Wang, Xia Song, Shufeng Fan, Jinzhan Su, Linying Ma, Jianxia Xu, Qinpan Rao   +8 more
doaj   +1 more source

Favorable clinical response to olipudase alfa in a patient with two variants of uncertain significance in SMPD1: a case report

Egyptian Journal of Medical Human Genetics
Background Acid sphingomyelinase deficiency (ASMD), also known as Niemann–Pick disease, is a rare lysosomal storage disorder caused by biallelic pathogenic variants in the Sphingomyelin phosphodiesterase 1 (SMPD1) gene, leading to the deficient activity ...
Luz María Sánchez-Sánchez, Jorge Álvarez-Longoria, Beatriz De la Fuente-Cortez, Valentina Martínez-Montoya, Ekaterina Sánchez-Romero   +4 more
doaj   +1 more source

Abstract 4161: Protecting Sphingomyelin Phosphodiesterase Acid Like 3B (SMPDL3b) enhances kidney function and reduces concurrent chemoradiotherapy-induced nephrotoxicity

Cancer Research, 2018
Abstract Background: Cisplatin is a widely used radiosensitizer. Dose-related and cumulative renal insufficiency, including acute renal failure, are the primary dose-limiting toxicities of cisplatin. The lipid-modulating enzyme sphingomyelin phosphodiesterase acid-like 3B (SMPDL3b) and Sphingosine 1-Phosphate Receptor-1 (S1P1) are ...
Anis Ahmad, Alla Mitrofanova, Saba Ansari, Junwei Shi, Yidong Yang, Sandra Merscher, Alessia Fornoni, Youssef Zeidan, Brian Marples   +8 more
openaire   +1 more source

The Neuroprotective Effect of Amitriptyline on Radiation-Induced Impairment of Hippocampal Neurogenesis

Dose-Response, 2019
The radioprotective effect of amitriptyline, an inhibitor of acid sphingomyelinase (ASMase), on radiation-induced impairment of hippocampal neurogenesis, loss of interneuron, and animal weight changes was investigated in BALB/c mice by immunostaining of ...
Yu Rong Guo, Zi Wei Liu, Shuang Peng, Meng Yun Duan, Jing Wei Feng, Wei Feng Wang, Yan Hua Xu, Xi Tang, Xiang Zhi Zhang, Bo Xu Ren, Feng Ru Tang   +10 more
doaj   +1 more source

An anatomic gene expression atlas of the adult mouse brain [PDF]

, 2009
Studying gene expression provides a powerful means of understanding structure-function relationships in the nervous system. The availability of genome-scale in situ hybridization datasets enables new possibilities for understanding brain organization ...
A Alvarez-Buylla, A MacKenzie-Graham, A MacKenzie-Graham, A Visel, Allan R Jones, Amy Bernard, AW Toga, AW Toga, Caroline C Overly, CE Gee, Chihchau Kuan, Chinh Dang, Chris Lau, David J Anderson, DC Van Essen, DN Abrous, Ed S Lein, ES Lein, G Marini, G Paxinos, Hemant Bokil, Hong-Wei Dong, HW Dong, Jason W Bohland, JB Kruskal, JB Kruskal, JL Price, John Hohmann, K Brodmann, LL Ng, Luis Puelles, LW Swanson, Lydia Ng, MA Zapala, MH DeGroot, Michael Hawrylycz, N Flames, P Voorn, PA Yushkevich, Partha P Mitra, RF Bonner, Sayan Pathak, SM Sherman, SM Sunkin, Susan M Sunkin, T Yamamori, VB Mountcastle, Y Ma, Y Nakamura   +48 more
core   +1 more source

Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer’s Disease

Drug Design, Development and Therapy, 2022
Yi-Yu Qi,1,* Xia Heng,1,* Zeng-Ying Yao,2 Shu-Yue Qu,1 Ping-Yuan Ge,1 Xin Zhao,1 Sai-jia Ni,2 Rui Guo,3 Nian-Yun Yang,1 Qi-Chun Zhang,2 Hua-Xu Zhu1 1Department of Traditional Chinese Medicine Processing and Preparation, Nanjing University of ...
Qi YY, Heng X, Yao ZY, Qu SY, Ge PY, Zhao X, Ni S, Guo R, Yang NY, Zhang QC, Zhu HX   +10 more
doaj  

Neurotoxicity and Intestinal Microbiota Dysbiosis in the Chinese Mitten Crab (Eriocheir sinensis) Induced by Anatoxin-a: A Microbiota–Intestine–Brain Axis Perspective

Microorganisms
Anatoxin-a (ANTX-a), a potent neurotoxin produced by various cyanobacterial species, poses a serious threat to aquatic organisms. This study investigated the neurotoxicity of ANTX-a on juvenile Chinese mitten crab (Eriocheir sinensis).
Huixia Feng, Shengyu Hu, Zihao Song, Ziqi Lin, Kai Zhang, Xianhui Ning, Cong Zhang, Shaowu Yin   +7 more
doaj   +1 more source