Results 101 to 110 of about 36,200 (174)

The Neuroprotective Effect of Amitriptyline on Radiation-Induced Impairment of Hippocampal Neurogenesis

Dose-Response, 2019
The radioprotective effect of amitriptyline, an inhibitor of acid sphingomyelinase (ASMase), on radiation-induced impairment of hippocampal neurogenesis, loss of interneuron, and animal weight changes was investigated in BALB/c mice by immunostaining of ...
Yu Rong Guo, Zi Wei Liu, Shuang Peng, Meng Yun Duan, Jing Wei Feng, Wei Feng Wang, Yan Hua Xu, Xi Tang, Xiang Zhi Zhang, Bo Xu Ren, Feng Ru Tang   +10 more
doaj   +1 more source

Abstract 4161: Protecting Sphingomyelin Phosphodiesterase Acid Like 3B (SMPDL3b) enhances kidney function and reduces concurrent chemoradiotherapy-induced nephrotoxicity

Cancer Research, 2018
Abstract Background: Cisplatin is a widely used radiosensitizer. Dose-related and cumulative renal insufficiency, including acute renal failure, are the primary dose-limiting toxicities of cisplatin. The lipid-modulating enzyme sphingomyelin phosphodiesterase acid-like 3B (SMPDL3b) and Sphingosine 1-Phosphate Receptor-1 (S1P1) are ...
Anis Ahmad, Alla Mitrofanova, Saba Ansari, Junwei Shi, Yidong Yang, Sandra Merscher, Alessia Fornoni, Youssef Zeidan, Brian Marples   +8 more
openaire   +1 more source

Modeling SMS driven conversion of ceramide to sphingomyelin reveals the existence of a positive feedback mechanism [PDF]

, 2022
In questa tesi presentiamo un modello matematico minimo per la conversione di un ceramide in sfingomielina catalizzata dall'enzima sfingomielina sintasi 1 (SMS1) basato sulle leggi della cinetica chimica.
Thomaseth, Caterina
core  

N-cholesteryl sphingomyelin—A synthetic sphingolipid with unique membrane properties [PDF]

, 2011
A sphingomyelin chimera in which the amide-linked acyl chain was replaced with cholesterol carbamate was prepared and its properties examined. The sphingomyelin/cholesterol chimera (N-cholesterol-D-erythro-sphingomyelin) was able to form unilamellar ...
Slotte, J. Peter, Katsumura, Shigeo, Christian Sergelius, Yamaguchi, Shou, Yamamoto, Tetsuya, Shigeo Katsumura, Shou Yamaguchi, J. Peter Slotte, Sergelius, Christian, Tetsuya Yamamoto   +9 more
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Involvement of Huanglian Jiedu Decoction on Microglia with Abnormal Sphingolipid Metabolism in Alzheimer’s Disease

Drug Design, Development and Therapy, 2022
Yi-Yu Qi,1,* Xia Heng,1,* Zeng-Ying Yao,2 Shu-Yue Qu,1 Ping-Yuan Ge,1 Xin Zhao,1 Sai-jia Ni,2 Rui Guo,3 Nian-Yun Yang,1 Qi-Chun Zhang,2 Hua-Xu Zhu1 1Department of Traditional Chinese Medicine Processing and Preparation, Nanjing University of ...
Qi YY, Heng X, Yao ZY, Qu SY, Ge PY, Zhao X, Ni S, Guo R, Yang NY, Zhang QC, Zhu HX   +10 more
doaj  

Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD

, 2010
Mark A Giembycz1, Stephen K Field2Departments of 1Physiology and Pharmacology and 2Medicine, Airway Inflammation Research Group, Faculty of Medicine, University of Calgary, Alberta, CanadaAbstract: In April 2010, the European Medicines Agency Committee ...
Stephen K Field, Mark A Giembycz
core  

Sphingolipid and ceramide homeostasis : potential therapeutic targets [PDF]

, 2012
Sphingolipids are ubiquitous in eukaryotic cells where they have been attributed a plethora of functions from the formation of structural domains to polarized cellular trafficking and signal transduction.
Smith, Terry, Simon A. Young, Denny, Paul, Young, Simon, Denny, Paul W., Mina, J.G., Mina, John, Denny, P.W., Smith, Terry K., Mina, John G., John G. Mina, Young, S.A., Smith, T.K., Paul W. Denny, Young, Simon A., Terry K. Smith   +15 more
core   +1 more source

Neurotoxicity and Intestinal Microbiota Dysbiosis in the Chinese Mitten Crab (Eriocheir sinensis) Induced by Anatoxin-a: A Microbiota–Intestine–Brain Axis Perspective

Microorganisms
Anatoxin-a (ANTX-a), a potent neurotoxin produced by various cyanobacterial species, poses a serious threat to aquatic organisms. This study investigated the neurotoxicity of ANTX-a on juvenile Chinese mitten crab (Eriocheir sinensis).
Huixia Feng, Shengyu Hu, Zihao Song, Ziqi Lin, Kai Zhang, Xianhui Ning, Cong Zhang, Shaowu Yin   +7 more
doaj   +1 more source

Investigations of the health benefits of buttermilk fat globule membrane lipid components [PDF]

, 2011
The milk fat globule membrane (MFGM) that surrounds fat globules in milk is a natural source of sphingolipids, phoshpholipids and proteins with defined anticancer properties.
Kuchta, Anna
core   +1 more source

High expression of SMPD4 promotes liver cancer and is associated with poor prognosis

BMC Research Notes
Objectives The expression of sphingomyelin phosphodiesterase 4 (SMPD4), a neutral sphingomyelin enzyme, is intricately associated with tumorigenesis and progression. However, its role in hepatocellular carcinoma (HCC) remains unclear.
Rongyue Wang, Ting Wang, Yanze Su, Zhiheng Lin, Xiaoping Liu, Yuanjun Jiao, Jikui Liu, Erbao Chen   +7 more
doaj   +1 more source