Results 101 to 110 of about 4,601 (147)

Adults With Acid Sphingomyelinase Deficiency Have Sustained Improvements in Clinical Outcomes With up to 5 Years of Olipudase Alfa Enzyme Replacement Therapy: ASCEND Trial Final Results. [PDF]

J Inherit Metab Dis
Wasserstein MP, Hollak CE, Barbato A, Gallagher RC, Giugliani R, Guelbert NB, Hennermann JB, Ikezoe T, Lachmann R, Lidove O, Mabe P, Mengel E, Scarpa M, Senates E, Tchan M, Thurberg BL, Villarrubia J, Armstrong NM, Bhushan S, Kim Y, Kumar M.   +20 more
europepmc   +1 more source

An update on schistosomicide and tumoricide in the future: arachidonic acid. [PDF]

Lipids Health Dis
Tallima H, El Ridi R.
europepmc   +1 more source

Early secretory pathway-resident Zn transporter proteins contribute to cellular sphingolipid metabolism through activation of sphingomyelin phosphodiesterase 1

Early secretory pathway-resident Zn transporter proteins contribute to cellular sphingolipid metabolism through activation of sphingomyelin phosphodiesterase 1
Sphingomyelin phosphodiesterase 1 (SMPD1) converts sphingomyelin into ceramide and phosphocholine; hence, loss of SMPD1 function causes abnormal accumulation of sphingomyelin in lysosomes, which results in the lipid-storage disorder Niemann-Pick disease (types A and B). SMPD1 activity is dependent on zinc, which is coordinated at the active site of the
openaire  

Bacterial extracellular vesicles as recyclable nutrient reservoirs. [PDF]

Nat Commun
Laimer-Digruber A, Edelbacher TV, Alinaghi M, Yu MSC, Chiang DM, Kirchner B, Wudy SI, Tschulenk W, Walter I, Kummer S, Ludwig C, Přibyl J, Pfaffl MW, Ehling-Schulz M.   +13 more
europepmc   +1 more source

The toxic effects of α-hemolysin and β-hemolysin produced by <i>Staphylococcus aureus</i>. [PDF]

Front Immunol
Zhang Q, Wu Y, Luo D, Fang F.
europepmc   +1 more source

Metabolic improvement in patients with acid sphingomyelinase deficiency following intravenous trehalose administration: an untargeted pharmacometabolomic study. [PDF]

Orphanet J Rare Dis
Khoshakhlagh M, Hasanpour M, Iranshahi M, Asili J, Tasbandi A, Jamialahmadi T, Sahebkar A, Iranshahy M.   +7 more
europepmc   +1 more source

Lipid metabolism as a marker for glioma aggressiveness. [PDF]

Biosci Rep
Ribas HT, Ribas GT, Paixão de Santana-Filho A, Jungles AG, Mesaros C, Guizelini D, Martinez GR, Trombetta-Lima M, Sassaki GL, Winnischofer SMB.   +9 more
europepmc   +1 more source

Molecular Maestro in the Lung: The Sphingolipid Rheostat. [PDF]

Am J Respir Cell Mol Biol
Rojas-Quintero J, Polverino F.
europepmc   +1 more source

Lipids regulate epidermal growth factor receptor activation by its ligands. [PDF]

Biochem Soc Trans
Hutchison JM, Lemmon MA.
europepmc   +1 more source

Obinutuzumab induces lysosomal destabilization via sphingomyelin-dependent inhibition of TRPML2. [PDF]

Sci Rep
Oh J, Jin N, Kwon S, Lee C, Baek H, Lee D, Kim JY.   +6 more
europepmc   +1 more source