Results 91 to 100 of about 7,161 (190)

The essential role of sphingolipids in TRPC5 ion channel localization and functionality within lipid rafts

Pharmacological Research
Sphingolipids are critical components of cellular membranes that play a pivotal role in modulating ion channel function by forming lipid rafts that stabilize and localize these channels.
Junliang Wan, Zhenying Hu, Huaiyi Zhu, Jingyi Li, Ziyuan Zheng, Zhitao Deng, Junyan Lu, Yu Chen, Gui-Lan Chen, Bo Zeng, Jin Zhang, Jingjing Duan   +11 more
doaj   +1 more source

Effect of PLA2G6 and SMPD1 Variants on the Lipid Metabolism in the Cerebrospinal Fluid of Patients with Parkinson's Disease: A Non-targeted Lipidomics Study

Neurology and Therapy, 2023
Introduction Sleep patterns are more frequently interrupted in patients with Parkinson's disease (PD), and it is still unclear whether genetic factors are involved in PD-related sleep disorders.
Yongang Li, GuiKai Ji, Mengjia Lian, Xuan Liu, Ying Xu, Yaxing Gui   +5 more
doaj   +1 more source

Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression [PDF]

, 2010
Background: Curcumin is a polyphenol and the one of the principle curcuminoids of the spice turmeric. Its antioxidant, anti-cancer and anti-inflammatory effects have been intensively studied.
Dan Feng, Lena Ohlsson, Rui-Dong Duan
core   +3 more sources

Oleoylethanolamide regulates intestinal stem cell activity and villus size via PPARα signaling pathway

iMetaOmics, Volume 3, Issue 1, March 2026.
First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang, Lanmei Yin, Zhaobin Wang, Jun Li, Xianglin Zeng, Qiye Wang, Jianzhong Li, Kang Xu, Huansheng Yang, Yulong Yin   +9 more
wiley   +1 more source

Increased sphingomyelin content impairs HDL biogenesis and maturation in human Niemann-Pick disease type B

Journal of Lipid Research, 2006
We previously reported that human Niemann-Pick Disease type B (NPD-B) is associated with low HDL. In this study, we investigated the pathophysiology of this HDL deficiency by examining both HDL samples from NPD-B patients and nascent high density ...
Ching Yin Lee, Alain Lesimple, Maxime Denis, Jérôme Vincent, Åsmund Larsen, Orval Mamer, Larbi Krimbou, Jacques Genest, Michel Marcil   +8 more
doaj   +1 more source

Placenta‐derived extracellular vesicles: Signal messengers shuttling across the maternal‐fetal barrier

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
In normal pregnancy, PEVs help maintain maternal–fetal immune tolerance while enabling controlled immune activation, promote endothelial migration, and support trophoblast invasion and syncytialization, strengthening antimicrobial defense. In pregnancy‐related disorders, dysregulated PEV signaling may drive endothelial dysfunction and hypertension, BBB
Jiale Du, Maliang Tao, Yanxuan Xiao, Zhijian Wang, Bo Situ, Lei Zheng   +5 more
wiley   +1 more source

ESI-MS quantitation of increased sphingomyelin in Niemann-Pick disease type B HDL

Journal of Lipid Research, 2005
HDLs have been proposed to have antiatherogenic properties because of their role in reverse cholesterol transport as lipid acceptors. To elucidate the phospholipid profile of these particles, we used electrospray ionization mass spectrometry to examine ...
Ching Yin Lee, Alain Lesimple, Åsmund Larsen, Orval Mamer, Jacques Genest   +4 more
doaj   +1 more source

Characterization of Phytoene Desaturase Knockout Carotenoid‐Deficient Microalgal Mutants Generated by Cas9‐Ribonucleoprotein Complexes

Physiologia Plantarum, Volume 178, Issue 2, March/April 2026.
ABSTRACT Phytoene desaturase (PDS; EC 1.3.5.5) is a key enzyme of the carotenoid biosynthetic pathway, catalyzing the desaturation of phytoene, precursor of all carotenoids. In this study, several PDS‐knockout (PDS‐KO) transformants of the chlorophyte microalga Chlamydomonas reinhardtii were generated using a reverse genetics strategy. Two single guide
Ana Molina‐Márquez, Simon Kelterborn, Peter Hegemann, Miguel Pérez‐Rodríguez, Javier Vigara, Rosa León   +5 more
wiley   +1 more source

Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages [PDF]

, 2012
Background The liver X receptors (LXRs) are oxysterol sensing nuclear receptors with multiple effects on metabolism and immune cells. However, the complete genome-wide cistrome of LXR in cells of human origin has not yet been provided.
Anke Wienecke-Baldacchino, Carsten Carlberg, Eckardt Treuter, Janine Diwo, Jussi Ryynänen, Knut R Steffensen, Lynn Welter-Stahl, Petri Pehkonen, Sami Heikkinen   +8 more
core   +2 more sources

Next-generation carrier screening [PDF]

, 2014
Purpose: Carrier screening for recessive Mendelian disorders traditionally employs focused genotyping to interrogate limited sets of mutations most prevalent in specific ethnic groups.
Breton, Benjamin, Chennagiri, Niru, Church, George M., Emhoff, John, Greger, Valerie, Hallam, Stephanie, Kennedy, Caleb J., Maganzini, David, Micale, Cynthia, Nizzari, Marcia M., Porreca, Gregory J., Saunders, Patrick, Towne, Charles F., Umbarger, Mark A.   +13 more
core   +1 more source