Results 1 to 10 of about 9,105 (228)

Sphingomyelins Prevent Propagation of Lipid Peroxidation—LC-MS/MS Evaluation of Inhibition Mechanisms

Molecules, 2020
Free radical driven lipid peroxidation is a chain reaction which can lead to oxidative degradation of biological membranes. Propagation vs. termination rates of peroxidation in biological membranes are determined by a variety of factors including fatty ...
Mike Lange, Simone Colombo, M Rosario M Domingues   +2 more
exaly   +3 more sources

Sphingomyelins and ceramides with VLCPUFAs are excluded from low-density raft-like domains in differentiating spermatogenic cells

Journal of Lipid Research, 2017
Rat spermatogenic cells contain sphingomyelins (SMs) and ceramides (Cers) with very long-chain PUFAs (VLCPUFAs) in nonhydroxylated (n-V) and 2-hydroxylated (h-V) forms. How these atypical species distribute among membrane fractions during differentiation
Gerardo M Oresti
exaly   +3 more sources

Presence of unsaturated sphingomyelins and changes in their composition during the life cycle of the moth Manduca sexta

Journal of Lipid Research, 2004
NMR and electrospray ionization tandem mass spectrometry were used to show for the first time the presence of sphingomyelins in extracts of the tobacco hornworm Manduca sexta (Lepidoptera).
Nicholas J Gibson, Lynne A Oland, Arpad Somogyi   +2 more
exaly   +3 more sources

Nonalcoholic fatty liver disease stratification by liver lipidomics

Journal of Lipid Research, 2021
Nonalcoholic fatty liver disease (NAFLD) is a common metabolic dysfunction leading to hepatic steatosis. However, NAFLD's global impact on the liver lipidome is poorly understood.
Olga Vvedenskaya, Tim Daniel Rose, Oskar Knittelfelder, Alessandra Palladini, Judith Andrea Heidrun Wodke, Kai Schuhmann, Jacobo Miranda Ackerman, Yuting Wang, Canan Has, Mario Brosch, Veera Raghavan Thangapandi, Stephan Buch, Thomas Züllig, Jürgen Hartler, Harald C. Köfeler, Christoph Röcken, Ünal Coskun, Edda Klipp, Witigo von Schoenfels, Justus Gross, Clemens Schafmayer, Jochen Hampe, Josch Konstantin Pauling, Andrej Shevchenko   +23 more
doaj   +1 more source

Plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetes

Journal of Lipid Research, 2021
Recent studies suggest that the type of saturated fatty acid bound to sphingolipids influences the biological activity of those sphingolipids. However, it is unknown whether associations of sphingolipids with diabetes may differ by the identity of bound ...
Amanda M. Fretts, Paul N. Jensen, Andrew N. Hoofnagle, Barbara McKnight, Barbara V. Howard, Jason Umans, Colleen M. Sitlani, David S. Siscovick, Irena B. King, Luc Djousse, Nona Sotoodehnia, Rozenn N. Lemaitre   +11 more
doaj   +1 more source

Different Lipid Signature in Fibroblasts of Long-Chain Fatty Acid Oxidation Disorders

Cells, 2021
Long-chain fatty acid oxidation disorders (lc-FAOD) are a group of diseases affecting the degradation of long-chain fatty acids. In order to investigate the disease specific alterations of the cellular lipidome, we performed undirected lipidomics in ...
Khaled I. Alatibi, Judith Hagenbuchner, Zeinab Wehbe, Daniela Karall, Michael J. Ausserlechner, Jerry Vockley, Ute Spiekerkoetter, Sarah C. Grünert, Sara Tucci   +8 more
doaj   +1 more source

Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations

Cancer Medicine, 2020
Large granular lymphocyte (LGL) leukemia is a rare hematological disorder with expansion of the T‐cell or natural killer (NK) cell lineage. Signal transducer and activator of transcription 3 (STAT3) exhibits somatic activating mutations in 30%‐40% of LGL
Kristine C. Olson, Katharine B. Moosic, Marieke K. Jones, Paige M. K. Larkin, Thomas L. Olson, Mariella F. Toro, Todd E. Fox, David J. Feith, Thomas P. Loughran Jr   +8 more
doaj   +1 more source

Sphingomyelin Lipidosis in a Cat [PDF]

Veterinary Pathology, 1987
A 7-month-old Balinese cat with progressive neurological dysfunction had histopathological lesions of brain, liver, kidney, spleen, and lung consistent with a lysosomal storage disease. Ultrastructural examination revealed lysosomal hypertrophy with membranous inclusions. Hepatic sphingomyelin and cholesterol were elevated 10 times
H J, Baker, P A, Wood, D A, Wenger, S U, Walkley, K, Inui, T, Kudoh, M C, Rattazzi, B L, Riddle   +7 more
openaire   +2 more sources

Correlation between metabolomic profile constituents and feline pancreatic lipase immunoreactivity

Journal of Veterinary Internal Medicine, 2022
Background Feline pancreatic lipase immunoreactivity (fPLI) is commonly used to diagnose pancreatitis in cats (FP). Untargeted metabolomics has been extensively applied in human and veterinary medicine, but no metabolomic studies regarding FP have been ...
Magdalena Maria Krasztel, Michał Czopowicz, Olga Szaluś‐Jordanow, Agata Moroz, Marcin Mickiewicz, Jarosław Kaba   +5 more
doaj   +1 more source

Membrane properties of sphingomyelins [PDF]

FEBS Letters, 2002
Sphingomyelin and phosphatidylcholine are important components in the external leaflet of cellular plasma membranes. In this review we compare the structure of these lipid molecules, with emphasis on the differences in hydrogen bonding capacity and membrane properties that arise from the small but significant differences in molecular structure.
Ramstedt, Bodil, Slotte, J.Peter
openaire   +2 more sources