Results 1 to 10 of about 13,992 (155)

Sphingomyelins Prevent Propagation of Lipid Peroxidation—LC-MS/MS Evaluation of Inhibition Mechanisms

Molecules, 2020
Free radical driven lipid peroxidation is a chain reaction which can lead to oxidative degradation of biological membranes. Propagation vs. termination rates of peroxidation in biological membranes are determined by a variety of factors including fatty ...
Mike Lange, Simone Colombo, M Rosário M Domingues   +2 more
exaly   +3 more sources

Lipid Subclasses Differentiate Insulin Resistance by Triglyceride–Glucose Index [PDF]

Metabolites
Background: Insulin resistance is a key driver of metabolic syndrome and related disorders, yet its underlying metabolic alterations remain incompletely understood.
Khaled Naja, Najeha Anwardeen, Omar Albagha, Mohamed A. Elrayess   +3 more
doaj   +2 more sources

Lipid balance and chemoresistance in cancer cells [PDF]

eLife
A shift in the balance between two lipids – cholesterol and sphingomyelin – makes hybrid epithelial-mesenchymal cancer cells less responsive to certain chemotherapy drugs.
Kaori Kanemaru, Yoshikazu Nakamura
doaj   +2 more sources

Low serum sphingolipids in children with attention deficit-hyperactivity disorder [PDF]

Frontiers in Neuroscience, 2015
Background: Attention deficit-hyperactivity disorder (ADHD) is the most prevalent neuropsychiatric condition in childhood. ADHD is a multifactorial trait with a strong genetic component. One neurodevelopmental hypothesis is that ADHD is associated with a
Marcela Patricia Henríquez-Henríquez, Marcela Patricia Henríquez-Henríquez, Sandra eSolari, Teresa eQuiroga, Benjamin I Kim, Richard J. Deckelbaum, Tilla S. Worgall   +6 more
doaj   +3 more sources

Selective association of plasma sphingolipid species with insulin sensitivity and secretion in normoglycemic Black and White American adults [PDF]

Experimental Biology and Medicine
Ceramides and other sphingolipids are associated with diabetes risk. Here, we examined the association of plasma sphingolipids with insulin sensitivity and secretion in people without diabetes.
Peace Asuzu, Naser Aliye Feto, Jim Wan, Frankie Stentz, Nawajes Mandal, Samuel Dagogo-Jack   +5 more
doaj   +2 more sources

Presence of unsaturated sphingomyelins and changes in their composition during the life cycle of the moth Manduca sexta

Journal of Lipid Research, 2004
NMR and electrospray ionization tandem mass spectrometry were used to show for the first time the presence of sphingomyelins in extracts of the tobacco hornworm Manduca sexta (Lepidoptera).
Arpad Somogyi, Robin Polt
exaly   +3 more sources

Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease [PDF]

, 2014
Chronic kidney disease (CKD) is part of a number of systemic and renal diseases and may reach epidemic proportions over the next decade. Efforts have been made to improve diagnosis and management of CKD.
Argilés, Àngel, Dakna, Mohammed, Delles, Christian, Duranton, Flore, Gayrard, Nathalie, Husi, Holger, Klein, Julie, Koeck, Thomas, Lundin, Ulrika, Mischak, Harald, Mullen, William, Nkuipou-Kenfack, Esther, Weinberger, Klaus M., Zürbig, Petra   +13 more
core   +12 more sources

Nonalcoholic fatty liver disease stratification by liver lipidomics

Journal of Lipid Research, 2021
Nonalcoholic fatty liver disease (NAFLD) is a common metabolic dysfunction leading to hepatic steatosis. However, NAFLD's global impact on the liver lipidome is poorly understood.
Olga Vvedenskaya, Tim Daniel Rose, Oskar Knittelfelder, Alessandra Palladini, Judith Andrea Heidrun Wodke, Kai Schuhmann, Jacobo Miranda Ackerman, Yuting Wang, Canan Has, Mario Brosch, Veera Raghavan Thangapandi, Stephan Buch, Thomas Züllig, Jürgen Hartler, Harald C. Köfeler, Christoph Röcken, Ünal Coskun, Edda Klipp, Witigo von Schoenfels, Justus Gross, Clemens Schafmayer, Jochen Hampe, Josch Konstantin Pauling, Andrej Shevchenko   +23 more
doaj   +1 more source

Metabolomics to unveil and understand phenotypic diversity between pathogen populations [PDF]

, 2010
Visceral leishmaniasis is caused by a parasite called Leishmania donovani, which every year infects about half a million people and claims several thousand lives. Existing treatments are now becoming less effective due to the emergence of drug resistance.
A Kamleh, A Scalbert, AK Chavali, Andris Jankevics, BO Keller, C Bern, C Christin, CC HsuChen, D Kumar, David G. Watson, DS Wishart, E Cauchetier, E Fahy, F Chappuis, F Hong, FR Opperdoes, G Barratt, Graham H. Coombs, H Ogata, HC Maltezou, HJ Atherton, HP de Koning, HW Murray, J Alvar, J Trygg, J Vandesompele, JC Mottram, Jean-Claude Dujardin, JV Olsen, K Zhang, K Zhang, Kirstyn Brunker, KW Tintaya, M Basselin, M Basselin, M Rakotomanga, MA Basinger, MA Doyle, MA Kamleh, MA Kamleh, MB Eisen, MK Wassef, MZ Alam, N Mbongo, N Van Meirvenne, R Breitling, R Breitling, R Breitling, RA Scheltema, RA Scheltema, RA Scheltema, Rainer Breitling, Richard A. Scheltema, Ruben t'Kindt, S Rijal, S Sundar, Saskia Decuypere, Suman Rijal, T Laurent, T Naderer, Timothy G. Geary, VP Shah, W Windig, WB Dunn   +63 more
core   +11 more sources

Plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetes

Journal of Lipid Research, 2021
Recent studies suggest that the type of saturated fatty acid bound to sphingolipids influences the biological activity of those sphingolipids. However, it is unknown whether associations of sphingolipids with diabetes may differ by the identity of bound ...
Amanda M. Fretts, Paul N. Jensen, Andrew N. Hoofnagle, Barbara McKnight, Barbara V. Howard, Jason Umans, Colleen M. Sitlani, David S. Siscovick, Irena B. King, Luc Djousse, Nona Sotoodehnia, Rozenn N. Lemaitre   +11 more
doaj   +1 more source