Metabolomic Signature of Visceral Adiposity: Insights from a Population-Based Cohort [PDF]
MetabolitesBackground: Visceral adipose tissue (VAT) is a key determinant of cardiometabolic risk, yet its underlying molecular mechanisms remain incompletely characterized.
Khaled Naja +4 more
doaj +2 more sources
Plasma lipids connecting olfaction with cognition and physical function [PDF]
Scientific ReportsOlfactory deficit is an early sign of neurodegenerative diseases, such as Alzheimer’s disease (AD), and is related to age-related cognitive and physical function decline. However, underlying biological processes are not fully understood.
Erin E. Greig +3 more
doaj +2 more sources
Cold-Induced Lipidomic Remodelling Is Associated With Brown Adipose Tissue Mean Radiodensity in Humans. [PDF]
Diabetes Obes MetabABSTRACT Aims Cold exposure activates brown adipose tissue (BAT) and promotes thermogenic and metabolic adaptations. While BAT activation has been linked to improved cardiometabolic health, how acute cold exposure reshapes the circulating lipidome in humans remains incompletely understood.
Zhang Y +7 more
europepmc +2 more sources
Lipid Subclasses Differentiate Insulin Resistance by Triglyceride–Glucose Index [PDF]
MetabolitesBackground: Insulin resistance is a key driver of metabolic syndrome and related disorders, yet its underlying metabolic alterations remain incompletely understood.
Khaled Naja +3 more
doaj +2 more sources
Lipid balance and chemoresistance in cancer cells [PDF]
eLifeA shift in the balance between two lipids – cholesterol and sphingomyelin – makes hybrid epithelial-mesenchymal cancer cells less responsive to certain chemotherapy drugs.
Kaori Kanemaru, Yoshikazu Nakamura
doaj +2 more sources
Selective association of plasma sphingolipid species with insulin sensitivity and secretion in normoglycemic Black and White American adults [PDF]
Experimental Biology and MedicineCeramides and other sphingolipids are associated with diabetes risk. Here, we examined the association of plasma sphingolipids with insulin sensitivity and secretion in people without diabetes.
Peace Asuzu +5 more
doaj +2 more sources
Targeted lipidomics between hPheo1 and SDHB KD cells reveal changes in bioactive lipids and PKC with polyamine pathway inhibition. [PDF]
Physiol RepAbstract Pheochromocytoma and paraganglioma with a succinate dehydrogenase B subunit (SDHB) pathogenic variant are associated with a significant chance for metastasis. Polyamine pathway inhibitor N1,N11‐diethylnorspermine (DENSPM) was previously shown to inhibit cell growth in progenitor cells derived from a human pheochromocytoma (hPheo1).
Alli AA +4 more
europepmc +2 more sources
Hepatology, EarlyView., 2022 Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario +12 more
wiley +1 more source
Journal of Lipid Research, 2014 Gangliosides and sulfatides (STs) are acidic glycosphingolipids (GSLs) that have one or more sialic acids or sulfate substituents, in addition to neutral sugars, attached to the C-1 hydroxyl group of the ceramide long chain base. TLC is a widely employed
Hyejung Park +2 more
doaj +1 more source
Tear Film Amphiphilic and Anti-Inflammatory Lipids in Bovine Pink Eye
Metabolites, 2018 Background: Tear film fluid serves as a dynamic barrier that both lubricates the eye and protects against allergens and infectious agents. However, a detailed analysis of a bacteria-induced immune response on the tear film lipidome has not been ...
Paul L. Wood +6 more
doaj +1 more source