Results 11 to 20 of about 11,288 (198)
Membrane properties of sphingomyelins [PDF]
FEBS Letters, 2002 Sphingomyelin and phosphatidylcholine are important components in the external leaflet of cellular plasma membranes. In this review we compare the structure of these lipid molecules, with emphasis on the differences in hydrogen bonding capacity and membrane properties that arise from the small but significant differences in molecular structure.
Ramstedt, Bodil, Slotte, J.Peter
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Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice. [PDF]
PLoS ONE, 2016 Obesity was reported to cause kidney injury by excessive accumulation of sphingolipids such as sphingomyelin and ceramide. Sphingomyelin synthase 2 (SMS2) is an important enzyme for hepatic sphingolipid homeostasis and its dysfunction is considered to ...
Masayuki Sugimoto +10 more
doaj +3 more sources
Plasma Sphingomyelins in Late-Onset Alzheimer’s Disease [PDF]
, 2021 BACKGROUND: Altered plasma levels of sphingolipids, including sphingomyelins (SM), have been found in mouse models of Alzheimer’s disease (AD) and in AD patient plasma samples. OBJECTIVE: This study assesses fourteen plasma SM species in a late-onset AD (
Fiandaca, Massimo S +7 more
core +1 more source
Human milk sphingomyelins and metabolomics: an enigma to be discovered
, 2022 Sphingomyelins, the most abundant sphingolipids in most mammalian cells, appear to be among the most represented polar lipids in breast milk. Despite the variability of the data reported in the literature, human milk sphingomyelins are qualitatively ...
Toto M. +4 more
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Sphingomyelins Prevent Propagation of Lipid Peroxidation—LC-MS/MS Evaluation of Inhibition Mechanisms [PDF]
, 2023 Free radical driven lipid peroxidation is a chain reaction which can lead to oxidative degradation of biological membranes. Propagation vs. termination rates of peroxidation in biological membranes are determined by a variety of factors including fatty ...
Chervet, Jean-Pierre +5 more
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Journal of Lipid and Atherosclerosis, 2020 Ceramide and sphingomyelin (SM) are major components of the double membrane-bound sphingolipids. Ceramide is an essential bioactive lipid involved in numerous cell processes including apoptosis, necrosis, and autophagy-dependent cell death. Inversely, SM
Makoto Taniguchi, Toshiro Okazaki
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Comparison of the Biophysical Properties of Racemic and d-Erythro-N-Acyl Sphingomyelins [PDF]
, 1999 In this study stereochemically pure d-erythro-sphingomyelins (SMs) with either 16:0 or 18:1cisΔ9 as the N-linked acyl-chain were synthesized. Our purpose was to examine the properties of these sphingomyelins and acyl-chain matched racemic (d-erythro/l ...
Slotte, J. Peter, Ramstedt, Bodil
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Cancer Medicine, 2020 Large granular lymphocyte (LGL) leukemia is a rare hematological disorder with expansion of the T‐cell or natural killer (NK) cell lineage. Signal transducer and activator of transcription 3 (STAT3) exhibits somatic activating mutations in 30%‐40% of LGL
Kristine C. Olson +8 more
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Sphingomyelin Lipidosis in a Cat [PDF]
Veterinary Pathology, 1987 A 7-month-old Balinese cat with progressive neurological dysfunction had histopathological lesions of brain, liver, kidney, spleen, and lung consistent with a lysosomal storage disease. Ultrastructural examination revealed lysosomal hypertrophy with membranous inclusions. Hepatic sphingomyelin and cholesterol were elevated 10 times
H J, Baker +7 more
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Correlation between metabolomic profile constituents and feline pancreatic lipase immunoreactivity
Journal of Veterinary Internal Medicine, 2022 Background Feline pancreatic lipase immunoreactivity (fPLI) is commonly used to diagnose pancreatitis in cats (FP). Untargeted metabolomics has been extensively applied in human and veterinary medicine, but no metabolomic studies regarding FP have been ...
Magdalena Maria Krasztel +5 more
doaj +1 more source