Results 31 to 40 of about 14,105 (264)

Improved quantitation of plasma lipids by direct gas-liquid chromatography

Journal of Lipid Research, 1969
A preliminary digestion of total plasma lipid extracts with phospholipase C, which converts the lysolecithins, lecithins, and sphingomyelins into monoglycerides, diglycerides, and ceramides, respectively, has been shown to facilitate subsequent ...
A. Kuksis, O. Stachnyk, B.J. Holub
doaj   +1 more source

Multi-omics driven predictions of response to acute phase combination antidepressant therapy: a machine learning approach with cross-trial replication

Translational Psychiatry, 2021
Combination antidepressant pharmacotherapies are frequently used to treat major depressive disorder (MDD). However, there is no evidence that machine learning approaches combining multi-omics measures (e.g., genomics and plasma metabolomics) can achieve ...
Jeremiah B. Joyce, Caroline W. Grant, Duan Liu, Siamak MahmoudianDehkordi, Rima Kaddurah-Daouk, Michelle Skime, Joanna Biernacka, Mark A. Frye, Taryn Mayes, Thomas Carmody, Paul E. Croarkin, Liewei Wang, Richard Weinshilboum, William V. Bobo, Madhukar H. Trivedi, Arjun P. Athreya   +15 more
doaj   +1 more source

Multi-Omics Reveals Mechanisms of Metabolic Rejuvenation in Aged Mice and Pre-Frail Older Men by Losartan. [PDF]

Aging Cell
Losartan partially reversed serum metabolomic aging signatures in both aged mice and pre‐frail older men, and this effect required functional angiotensin II receptors in mice. Cross‐species analyses suggest aging shifts circulating metabolites in opposite directions in mice versus humans, particularly among lipids, with losartan partially normalizing ...
Bene MR, Zhang C, Westbrook R, Gabrawy M, Marx R, Wu Y, Khadeer M, Ubaida-Mohien C, Ferrucci L, Moaddel R, Le A, Walston JD, Lee JL, Abadir PM.   +13 more
europepmc   +2 more sources

Generation and quality control of lipidomics data for the alzheimers disease neuroimaging initiative cohort. [PDF]

, 2018
Alzheimers disease (AD) is a major public health priority with a large socioeconomic burden and complex etiology. The Alzheimer Disease Metabolomics Consortium (ADMC) and the Alzheimer Disease Neuroimaging Initiative (ADNI) aim to gain new biological ...
AA Willette, B De Strooper, CA McLean, CC Liu, CR Jack Jr., CS McCoin, DA Butterfield, F Picconi, F Zhu, G McKhann, G Verdile, H Tsugawa, J Fahrmann, J Gotz, JM Weir, KH Ashe, KP Ng, L St John-Williams, MG Spillantini, MR Wenk, MR Wenk, MW Weiner, MW Weiner, MW Wong, O Quehenberger, P Edison, P Proitsi, P Proitsi, R Kaddurah-Daouk, R Ossenkoppele, RC Petersen, S Kullmann, SG Mueller, SM de la Monte, SN Jackson, T Cajka, T Cajka, T Cajka, T Cajka, T Kind, TJ Montine, X Han, Y Huang   +42 more
core   +2 more sources

Effects of Pregnancy on Plasma Sphingolipids Using a Metabolomic and Quantitative Analysis Approach

Metabolites, 2023
Changes in the maternal metabolome, and specifically the maternal lipidome, that occur during pregnancy are relatively unknown. The objective of this investigation was to evaluate the effects of pregnancy on sphingolipid levels using metabolomics ...
Luke F. Enthoven, Yuanyuan Shi, Emily Fay, Agnes Kim, Sue Moreni, Jennie Mao, Nina Isoherranen, Rheem A. Totah, Mary F. Hebert   +8 more
doaj   +1 more source

Metabolic characterization of the natural progression of chronic hepatitis B [PDF]

, 2016
Background: Worldwide, over 350 million people are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing progressive liver diseases.
Berger, R. (Ruud), Boonstra, P.A. (André), Hankemeier, T. (Thomas), Harms, A.C. (Amy), Hou, J. (Jun), Schoeman, J.C. (Johannes C.), Vreeken, R. (Rob)   +6 more
core   +1 more source

Raft-based sphingomyelin interactions revealed by new fluorescent sphingomyelin analogs [PDF]

Journal of Cell Biology, 2017
Sphingomyelin (SM) has been proposed to form cholesterol-dependent raft domains and sphingolipid domains in the plasma membrane (PM). How SM contributes to the formation and function of these domains remains unknown, primarily because of the scarcity of suitable fluorescent SM analogs.
Masanao Kinoshita, Kenichi G.N. Suzuki, Nobuaki Matsumori, Misa Takada, Hikaru Ano, Kenichi Morigaki, Mitsuhiro Abe, Asami Makino, Toshihide Kobayashi, Koichiro M. Hirosawa, Takahiro K. Fujiwara, Akihiro Kusumi, Michio Murata   +12 more
openaire   +2 more sources

Fatty acid composition of human brain sphingomyelins: normal variation with age and changes during myelin disorders

Journal of Lipid Research, 1965
Sphingomyelins have been isolated in almost quantitative yield from normal and pathological human nervous tissues, and their fatty acid compositions determined by gas–liquid chromatography.
Stina Ställberg-Stenhagen, Lars Svennerholm   +1 more
doaj   +1 more source

Liquid chromatography-mass spectrometry-based metabolomic profiling reveals sex differences of lipid metabolism among the elderly from Southwest China

BMC Geriatrics, 2023
Background The sexual dimorphism represents one of the triggers of the metabolic disparities while the identification of sex-specific metabolites in the elderly has not been achieved.
Yuan-Jun Huang, Wei Ke, Ling Hu, You-Dong Wei, Mei-Xue Dong   +4 more
doaj   +1 more source

Long-term biopermanence of ceramides, cholesteryl esters, and ether-linked triglycerides with very-long-chain PUFA in the cadmium-damaged testis [PDF]

, 2014
Cadmium is known to harm rat testis by causing the dose-dependent apoptotic or necrotic death of seminiferous epithelium cells. Here we investigated how this affects the lipids with long-chain (C18-C22) and very-long-chain (C24-C32) polyunsaturated fatty
Aveldaño, Marta I., Zanetti, Samanta Romina   +1 more
core   +2 more sources