Results 21 to 30 of about 9,105 (228)

Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice. [PDF]

PLoS ONE, 2016
Obesity was reported to cause kidney injury by excessive accumulation of sphingolipids such as sphingomyelin and ceramide. Sphingomyelin synthase 2 (SMS2) is an important enzyme for hepatic sphingolipid homeostasis and its dysfunction is considered to ...
Masayuki Sugimoto, Masato Wakabayashi, Yoichi Shimizu, Takeshi Yoshioka, Kenichi Higashino, Yoshito Numata, Tomohiko Okuda, Songji Zhao, Shota Sakai, Yasuyuki Igarashi, Yuji Kuge   +10 more
doaj   +1 more source

Improved quantitation of lipid classes using supercritical fluid chromatography with a charged aerosol detector

Journal of Lipid Research, 2019
Quantitatively and rapidly analyzing lipids is necessary to elucidate their biological functions. Herein, we developed a quantitative method for various lipid classes using supercritical fluid chromatography (SFC) coupled with a charged aerosol detector (
Hiroaki Takeda, Masatomo Takahashi, Takeshi Hara, Yoshihiro Izumi, Takeshi Bamba   +4 more
doaj   +1 more source

Improved quantitation of plasma lipids by direct gas-liquid chromatography

Journal of Lipid Research, 1969
A preliminary digestion of total plasma lipid extracts with phospholipase C, which converts the lysolecithins, lecithins, and sphingomyelins into monoglycerides, diglycerides, and ceramides, respectively, has been shown to facilitate subsequent ...
A. Kuksis, O. Stachnyk, B.J. Holub
doaj   +1 more source

Changes in Plasma Phospholipid Metabolism Are Associated with Clinical Manifestations of Systemic Sclerosis

Diagnostics, 2021
Systemic sclerosis (SSc) is an autoimmune disease with fibrosis of the skin and/or internal organs, causing a decrease in quality of life and survival. There is no causative therapy, and the pathophysiology of the SSc remains unclear. Studies showed that
Marija Geroldinger-Simić, Thomas Bögl, Markus Himmelsbach, Norbert Sepp, Wolfgang Buchberger   +4 more
doaj   +1 more source

Multi-omics driven predictions of response to acute phase combination antidepressant therapy: a machine learning approach with cross-trial replication

Translational Psychiatry, 2021
Combination antidepressant pharmacotherapies are frequently used to treat major depressive disorder (MDD). However, there is no evidence that machine learning approaches combining multi-omics measures (e.g., genomics and plasma metabolomics) can achieve ...
Jeremiah B. Joyce, Caroline W. Grant, Duan Liu, Siamak MahmoudianDehkordi, Rima Kaddurah-Daouk, Michelle Skime, Joanna Biernacka, Mark A. Frye, Taryn Mayes, Thomas Carmody, Paul E. Croarkin, Liewei Wang, Richard Weinshilboum, William V. Bobo, Madhukar H. Trivedi, Arjun P. Athreya   +15 more
doaj   +1 more source

Fatty acid composition of human brain sphingomyelins: normal variation with age and changes during myelin disorders

Journal of Lipid Research, 1965
Sphingomyelins have been isolated in almost quantitative yield from normal and pathological human nervous tissues, and their fatty acid compositions determined by gas–liquid chromatography.
Stina Ställberg-Stenhagen, Lars Svennerholm   +1 more
doaj   +1 more source

Effects of Pregnancy on Plasma Sphingolipids Using a Metabolomic and Quantitative Analysis Approach

Metabolites, 2023
Changes in the maternal metabolome, and specifically the maternal lipidome, that occur during pregnancy are relatively unknown. The objective of this investigation was to evaluate the effects of pregnancy on sphingolipid levels using metabolomics ...
Luke F. Enthoven, Yuanyuan Shi, Emily Fay, Agnes Kim, Sue Moreni, Jennie Mao, Nina Isoherranen, Rheem A. Totah, Mary F. Hebert   +8 more
doaj   +1 more source

Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation[S]

Journal of Lipid Research, 2009
Molecular events involved in successful embryo implantation are not well understood. In this study, we used MALDI imaging mass spectrometry (IMS) technologies to characterize the spatial and temporal distribution of phospholipid species associated with ...
Kristin E. Burnum, Dale S. Cornett, Satu M. Puolitaival, Stephen B. Milne, David S. Myers, Susanne Tranguch, H. Alex Brown, Sudhansu K. Dey, Richard M. Caprioli   +8 more
doaj   +1 more source

Liquid chromatography-mass spectrometry-based metabolomic profiling reveals sex differences of lipid metabolism among the elderly from Southwest China

BMC Geriatrics, 2023
Background The sexual dimorphism represents one of the triggers of the metabolic disparities while the identification of sex-specific metabolites in the elderly has not been achieved.
Yuan-Jun Huang, Wei Ke, Ling Hu, You-Dong Wei, Mei-Xue Dong   +4 more
doaj   +1 more source

Altered Sphingolipids, Glycerophospholipids, and Lysophospholipids Reflect Disease Status in Idiopathic Steroid-Sensitive Nephrotic Syndrome in Children: A Non-Targeted Metabolomic Study

Cells
Idiopathic steroid-sensitive nephrotic syndrome (ISSNS) is the most common glomerular disease in children, yet its molecular mechanisms and lipid-mediated pathophysiology remain poorly understood.
Takahiro Kanai, Hideo Ogiso, Jun Aoyagi, Masanori Kurosaki, Tomomi Maru, Marika Ishii, Kazuya Tanimoto, Mitsuaki Yoshino, Yuri Yamashita, Toshihiro Tajima, Ryozo Nagai, Kenichi Aizawa   +11 more
doaj   +1 more source