Results 21 to 30 of about 14,105 (264)
Imaging Mass Spectrometry Reveals Acyl-Chain- and Region-Specific Sphingolipid Metabolism in the Kidneys of Sphingomyelin Synthase 2-Deficient Mice. [PDF]
PLoS ONE, 2016 Obesity was reported to cause kidney injury by excessive accumulation of sphingolipids such as sphingomyelin and ceramide. Sphingomyelin synthase 2 (SMS2) is an important enzyme for hepatic sphingolipid homeostasis and its dysfunction is considered to ...
Masayuki Sugimoto +10 more
doaj +1 more source
Tear Film Amphiphilic and Anti-Inflammatory Lipids in Bovine Pink Eye
Metabolites, 2018 Background: Tear film fluid serves as a dynamic barrier that both lubricates the eye and protects against allergens and infectious agents. However, a detailed analysis of a bacteria-induced immune response on the tear film lipidome has not been ...
Paul L. Wood +6 more
doaj +1 more source
Journal of Lipid Research, 2019 Quantitatively and rapidly analyzing lipids is necessary to elucidate their biological functions. Herein, we developed a quantitative method for various lipid classes using supercritical fluid chromatography (SFC) coupled with a charged aerosol detector (
Hiroaki Takeda +4 more
doaj +1 more source
Cross-Platform Comparison of Untargeted and Targeted Lipidomics Approaches on Aging Mouse Plasma. [PDF]
, 2018 Lipidomics - the global assessment of lipids - can be performed using a variety of mass spectrometry (MS)-based approaches. However, choosing the optimal approach in terms of lipid coverage, robustness and throughput can be a challenging task.
Brunet, Anne +6 more
core +3 more sources
Membrane properties of sphingomyelins [PDF]
FEBS Letters, 2002 Sphingomyelin and phosphatidylcholine are important components in the external leaflet of cellular plasma membranes. In this review we compare the structure of these lipid molecules, with emphasis on the differences in hydrogen bonding capacity and membrane properties that arise from the small but significant differences in molecular structure.
Ramstedt, Bodil, Slotte, J.Peter
openaire +2 more sources
Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts
, 2020 A comprehensive characterization of the lipidome from limited starting material remains very challenging. Here we report a high-sensitivity lipidomics workflow based on nanoflow liquid chromatography and trapped ion mobility spectrometry (TIMS).
Barsch, A. +8 more
core +1 more source
Experimental Biology and Medicine, 1964 SummaryThe sphingomyelin region of human plasma lipids, entirely free from lecithin, has been fractionated into two components by thin-layer chromatography. Both components had properties characteristic of sphingomyelins, but markedly different fatty acid patterns, acids above C20 being concentrated in the less-polar material.
P D, WOOD, S, HOLTON
openaire +2 more sources
Diagnostics, 2021 Systemic sclerosis (SSc) is an autoimmune disease with fibrosis of the skin and/or internal organs, causing a decrease in quality of life and survival. There is no causative therapy, and the pathophysiology of the SSc remains unclear. Studies showed that
Marija Geroldinger-Simić +4 more
doaj +1 more source
Automated workflow-based exploitation of pathway databases provides new insights into genetic associations of metabolite profiles [PDF]
, 2013 Background: Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) that associate with clinical phenotypes, but these SNPs usually explain just a small part of the heritability and have relatively modest
Adamski, J. (Jerzy) +60 more
core +1 more source
a targeted metabolomic approach in two German prospective cohorts [PDF]
, 2018 Metabolomic approaches in prospective cohorts may offer a unique snapshot into early metabolic perturbations that are associated with a higher risk of cardiovascular diseases (CVD) in healthy people.
Adamski, Jerzy +13 more
core +1 more source