Exploring the role of 338 cerebrospinal fluid metabolites in primary brain malignancies risk: a Mendelian randomization study. [PDF]
He H +8 more
europepmc +1 more source
Qualitative and Quantitative Analysis of Sphingomyelin in Whey Protein
Angela Kohut
openalex +1 more source
A Global Metabolomic and Lipidomic Landscape of Human Plasma Across the Lifespan
Liu et al. provide a comprehensive analysis of dynamic plasma metabolomic and lipidomic changes in humans across the lifespan, identifying age‐specific metabolic trajectories and developing a metabolite‐based aging clock, offering insights into metabolic reprogramming and potential biomarkers for aging‐related health interventions.
Xinru Liu +6 more
wiley +1 more source
Causal relationship between plasma lipidome and 6 types of cancer: A Mendelian randomization study. [PDF]
Tang N, Tang J, Zhang J, Chen H, Yang R.
europepmc +1 more source
Sphingomyelins of Local Fat Depots and Blood Serum as Promising Biomarkers of Cardiovascular Diseases [PDF]
E. V. Belik +6 more
openalex +1 more source
Alteration of the Sphingomyelin/Ceramide Pathway Is Associated with Resistance of Human Breast Carcinoma MCF7 Cells to Tumor Necrosis Factor-α-mediated Cytotoxicity [PDF]
Zhenzi Cai +6 more
openalex +1 more source
The illustration indicates that increased BST2 expression in Schwann cells leads to cochlear nerve demyelination, accelerating hearing loss in ARHL. The upregulation of BST2 reduces POU6F1 expression by activating the NF‐κB pathway, which impairs MPZ transcription and Schwann cell migration, ultimately contributing to neural demyelination in ARHL ...
Mengxiao Liu +8 more
wiley +1 more source
Sphingolipids are vital components of cell membranes. Metabolic disruptions of sphingolipids, including ceramide and sphingosine‐1‐phosphate, are linked to neurological disorders. This article summarizes the classification, structure, and metabolic processes of sphingolipids, and the physiological and pathological effects of sphingolipid metabolism and
Tian Li +7 more
wiley +1 more source
Lipidomic profiling unveils sex differences in diabetes risk: Implications for precision medicine
This study uncovered sex‐specific metabolic and lipidomic signatures of prediabetes. In PREVADIAB2 (n = 953), clustering by insulin traits revealed four phenotypes. Lipidomics showed women enriched in dihydroceramides and sphingomyelins, while men displayed a higher ceramide/sphingomyelin ratio. These sex‐metabolic phenotypes expose distinct lipidomes,
Ana F. Pina +8 more
wiley +1 more source

