Results 241 to 250 of about 81,593 (273)

Amyloid‐beta (1–40) peptide is associated with systemic metabolic health

European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.
Plasma amyloid‐beta 1–40 (Aβ40) levels were measured in 449 individuals without overt cardiovascular disease. Higher Aβ40 was independently associated with metabolic syndrome, dyslipidemia (low HDL‐C, high triglycerides), insulin resistance (TyG index), diabetes mellitus and increased BARD score indicating liver fibrosis risk.
Kateryna Sopova, Dimitrios Delialis, Evmorfia Aivalioti, Georgios Georgiopoulos, Stravros Athanasopoulos, Georgios Zervas, Christina Konstantaki, Marco Sachse, Martin Sigl, Daniel Duerschmied, Simon Tual‐Chalot, Kimon Stamatelopoulos, Konstantinos Stellos   +12 more
wiley   +1 more source

Unveiling the Proteomic Landscape of Extracellular Vesicles: Implications for Neurodegeneration and Neuroprotection

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Extracellular vesicles (EVs) are tiny, membrane‐covered packets that cells naturally release to send molecular information to one another. In the brain, they function as couriers that move proteins, lipids, and other signals between neurons, glial cells, and the blood–brain barrier.
Berenice N. Bernal‐Vicente, Isaac Ponce, Emmanuel Ríos‐Castro, Perla Moreno‐Castilla, Luis B. Tovar‐y‐Romo   +4 more
wiley   +1 more source

Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health

Journal of Internal Medicine, Volume 299, Issue 1, Page 20-43, January 2026.
Abstract Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline. Although amyloid‐β and tau pathologies remain central to our understanding of AD, growing evidence suggests that disrupted lipid metabolism and impaired bioenergetics are closely linked to these hallmark features. Genetic, lipidomic
Silvia Maioli, Ivan Nalvarte, Maria Ankarcrona, Marianne Schultzberg, Kristen L. Zuloaga, Julen Goikolea, Pieter Jelle Visser, Bart De Strooper, Bengt Winblad, Paola Pizzo, Pete A. Williams, Patricia Rodriguez‐Rodriguez, Luana Naia   +12 more
wiley   +1 more source

Adipose‐Derived Extracellular Vesicles and Intercellular Crosstalk With Skeletal Muscle: Implications for Sarcopenic Obesity and Metabolic Dysregulation

Obesity Reviews, Volume 27, Issue 1, Page 1-22, January 2026.
ABSTRACT Sarcopenic obesity, characterized by the concurrent presence of excess adiposity and diminished skeletal muscle mass and function, is closely linked to frailty, chronic inflammation, and insulin resistance. The increasing prevalence of sarcopenic obesity is driven by the global aging population, widespread adoption of sedentary lifestyles, and
Michael Macleod, Joshua Price, Elpida Tsonou, David J. Baker, Kostas Tsintzas, Simon W. Jones   +5 more
wiley   +1 more source

Risks for human health related to the presence of plant lectins in food

EFSA Journal, Volume 24, Issue 1, January 2026.
Abstract The European Commission asked the European Food Safety Authority (EFSA) to assess the risk related to the presence of plant lectins in food. Based on the available evidence, the CONTAM Panel considered only phytohaemagglutinin (PHA), a legume lectin from beans (Phaseolus sp.), for the risk characterisation.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, James Kevin Chipman, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Isabelle P. Oswald, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Hanne Frøkiær, Bettina Grasl‐Kraupp, Patrick Mulder, Pierre Rougé, Heather Wallace, Marios Georgiadis, José Ángel Gómez Ruiz, Eirini Kouloura, Olaf Mosbach‐Schulz, Lydia Alarcón Asensio, Eleni Gkimprixi, Evangelia Ntzani   +30 more
wiley   +1 more source

Coronary artery disease risk and lipidomic profiles are similar in hyperlipidemias with family history and population-ascertained hyperlipidemias [PDF]

, 2019
et al,, Stitziel, Nathan O
core   +1 more source

Novel Causal Evidence for the Role of Circulating Lipid Metabolites in Breast Cancer Risk: A Bidirectional Mendelian Randomization Analysis. [PDF]

J Nutr Metab
Zeng C, Liu S, Wei Y, Qi Y, Tan Y, Qian H, Wang J, Ma F.   +7 more
europepmc   +1 more source

Communications Chemistry 2025 Ganglioside GM1 slows down Aβ(1-42) aggregation by a primary nucleation inhibitory mechanism that is modulated by sphingomyelin and cholesterol

Esbjörner, Elin
openalex   +1 more source

Resolving versus non-resolving sphingolipid dynamics during macrophage activation: a time-resolved metabolic analysis. [PDF]

J Lipid Res
Chiappa NF, Lal N, Botchwey EA.
europepmc   +1 more source

Scavenger Receptor BI Deficiency in Mice Is Associated With Plasma Ceramide and Sphingomyelin Accumulation and a Reduced Cholesteryl Ester Fatty Acid Length and Unsaturation Degree [PDF]

Menno Hoekstra, Zhengzheng Zhang, Peter W. Lindenburg, Miranda Van Eck   +3 more
openalex   +1 more source